| Genetic change investigation in DOCK1 gene in an Iranian family with sign and symptoms of temporomandibular joint disorder (TMD). | Genetic change investigation in DOCK1 gene in an Iranian family with sign and symptoms of temporomandibular joint disorder (TMD).
Najafi S, Hashemi-Gorji F, Roudgari H, Goudarzi M, Jafarzadegan AM, Sheykhbahaei N. | 08/16/2024 |
| ESRP1 controls biogenesis and function of a large abundant multiexon circRNA. | ESRP1 controls biogenesis and function of a large abundant multiexon circRNA.
Liu D, Dredge BK, Bert AG, Pillman KA, Toubia J, Guo W, Dyakov BJA, Migault MM, Conn VM, Conn SJ, Gregory PA, Gingras AC, Patel D, Wu B, Goodall GJ., Free PMC Article | 02/14/2024 |
| DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway. | DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.
Xu Y, Liu X, Zeng W, Zhu Y, Dong J, Wu F, Chen C, Sharma S, Lin Y., Free PMC Article | 11/20/2023 |
| CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis. | CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis.
Li S, Liu F, Zheng K, Wang W, Qiu E, Pei Y, Wang S, Zhang J, Zhang X., Free PMC Article | 03/26/2022 |
| LINC00665 promotes the progression of acute myeloid leukemia by regulating the miR-4458/DOCK1 pathway. | LINC00665 promotes the progression of acute myeloid leukemia by regulating the miR-4458/DOCK1 pathway.
Yang X, Wang Y, Pang S, Li X, Wang P, Ma R, Ma Y, Song C., Free PMC Article | 12/18/2021 |
| Circular RNA DOCK1 downregulates microRNA-124 to induce the growth of human thyroid cancer cell lines. | Circular RNA DOCK1 downregulates microRNA-124 to induce the growth of human thyroid cancer cell lines.
Cui W, Xue J. | 08/28/2021 |
| TBOPP enhances the anticancer effect of cisplatin by inhibiting DOCK1 in renal cell carcinoma. | TBOPP enhances the anticancer effect of cisplatin by inhibiting DOCK1 in renal cell carcinoma.
Zhang W, Zheng X, Xie S, Zhang S, Mao J, Cai Y, Lu X, Chen W, Ni H, Xie L., Free PMC Article | 04/17/2021 |
| Identifying and treating ROBO1(-ve) /DOCK1(+ve) prostate cancer: An aggressive cancer subtype prevalent in African American patients. | Identifying and treating ROBO1(-ve) /DOCK1(+ve) prostate cancer: An aggressive cancer subtype prevalent in African American patients.
Ferrari MG, Ganaie AA, Shabenah A, Mansini AP, Wang L, Murugan P, Davicioni E, Wang J, Deng Y, Hoeppner LH, Warlick CA, Konety BR, Saleem M., Free PMC Article | 10/10/2020 |
| CircDOCK1 affected the progression of BC via modulation of circDOCK1/hsa-miR-132-3p/Sox5 pathway. | Circular RNA DOCK1 promotes bladder carcinoma progression via modulating circDOCK1/hsa-miR-132-3p/Sox5 signalling pathway.
Liu P, Li X, Guo X, Chen J, Li C, Chen M, Liu L, Zhang X, Zu X., Free PMC Article | 08/3/2019 |
| DOCK180 has an indispensable role in pregnancy establishment as knocking down Dock180 abrogates pregnancy by a consolidated impact on decidualization and angiogenesis by regulating AIRE nuclear entry. | Silencing of dedicator of cytokinesis (DOCK180) obliterates pregnancy by interfering with decidualization due to blockage of nuclear entry of autoimmune regulator (AIRE).
Mohan JJ, Narayan P, Padmanabhan RA, Joseph S, Kumar PG, Laloraya M. | 07/27/2019 |
| High DOCK1 expression is associated with Oral squamous cell carcinoma. | CircDOCK1 suppresses cell apoptosis via inhibition of miR‑196a‑5p by targeting BIRC3 in OSCC.
Wang L, Wei Y, Yan Y, Wang H, Yang J, Zheng Z, Zha J, Bo P, Tang Y, Guo X, Chen W, Zhu X, Ge L., Free PMC Article | 09/1/2018 |
| Dock1 modulation by miR-31 plays an important function in glioma invasion | Dock1 promotes the mesenchymal transition of glioma and is modulated by MiR-31.
Zhang B, Li H, Yin C, Sun X, Zheng S, Zhang C, Shi L, Liu Y, Lu S. | 04/28/2018 |
| In summary, this investigation identifies an EGFR-DOCK180-RAC1-MLK3-JNK signaling axis that drives glioblastoma cell migration and dissemination.IMPLICATIONS: On the basis of these findings, MLK3 emerges as a potential therapeutic target for the treatment of glioblastoma | EGFR Signals through a DOCK180-MLK3 Axis to Drive Glioblastoma Cell Invasion.
Misek SA, Chen J, Schroeder L, Rattanasinchai C, Sample A, Sarkaria JN, Gallo KA. | 04/21/2018 |
| one statistically significant common variant in the DOCK1 gene was associated with DeltaBMI in GI cancer and COPD cases providing support for at least partially shared aetiology of DeltaBMI in complex diseases. | Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.
McDonald MN, Won S, Mattheisen M, Castaldi PJ, Cho MH, Rutten E, Hardin M, Yip WK, Rennard SI, Lomas DA, Wouters EFM, Agusti A, Casaburi R, Lange CP, O'Connor G, Hersh CP, Silverman EK., Free PMC Article | 03/31/2018 |
| Taken together, these results indicate that DOCK1 is a critical regulator of the malignant phenotypes induced by Rac1(P29S), and suggest that targeting DOCK1 might be an effective approach to treat cancers associated with Rac1(P29S) mutation. | DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1(P29S) mutation.
Tomino T, Tajiri H, Tatsuguchi T, Shirai T, Oisaki K, Matsunaga S, Sanematsu F, Sakata D, Yoshizumi T, Maehara Y, Kanai M, Cote JF, Fukui Y, Uruno T. | 03/24/2018 |
| Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1-Dock180 and intersectin 1/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 = ELMO domain-containing protein 1; Dock180 = dedicator of cytokinesis protein 1 180 kDa) | Cell adhesion controlled by adhesion G protein-coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo-Dock.
Hernández-Vásquez MN, Adame-García SR, Hamoud N, Chidiac R, Reyes-Cruz G, Gratton JP, Côté JF, Vázquez-Prado J., Free PMC Article | 08/12/2017 |
| stimulation of the DOCK180 pathway represents an alternative mechanism of PTP1B inhibitor-stimulated endothelial cell motility, which does not require concomitant VEGFR2 activation as a prerequisite. | PTP1B inhibitor promotes endothelial cell motility by activating the DOCK180/Rac1 pathway.
Wang Y, Yan F, Ye Q, Wu X, Jiang F., Free PMC Article | 02/25/2017 |
| Thus, Elmo1 and Dock180 facilitate blood vessel formation by stabilization of the endothelium during angiogenesis. | The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development.
Schäker K, Bartsch S, Patry C, Stoll SJ, Hillebrands JL, Wieland T, Kroll J., Free PMC Article | 05/23/2015 |
| High DOCK180 expression is associated with serous ovarian cancer. | Elmo1 helps dock180 to regulate Rac1 activity and cell migration of ovarian cancer.
Wang J, Dai JM, Che YL, Gao YM, Peng HJ, Liu B, Wang H, Linghu H. | 01/10/2015 |
| our findings describe a novel mechanism by which EGFRvIII drives glioma tumorigenesis and invasion through protein kinase A-dependent phosphorylation of Dock180 | EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180.
Feng H, Hu B, Vuori K, Sarkaria JN, Furnari FB, Cavenee WK, Cheng SY., Free PMC Article | 06/21/2014 |
| findings indicate that a chemokine-controlled pathway, consisting of Galphai2, ELMO1/Dock180, Rac1 and Rac2, regulates the actin cytoskeleton during breast cancer metastasis | Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis.
Li H, Yang L, Fu H, Yan J, Wang Y, Guo H, Hao X, Xu X, Jin T, Zhang N., Free PMC Article | 10/26/2013 |
| Dock180 could act as a pro-survival molecule in H9C2 cardiomyocytes via activation of its downstream pro-survival signaling molecule, AKT. | Pro-survival effect of Dock180 overexpression on rat-derived H9C2 cardiomyocytes.
Yan A, Li G, Zhang X, Zhu B, Linghu H., Free PMC Article | 10/19/2013 |
| Solved is the solution structure of DOCK180 SH3 domain, which shares similar target binding features with the SH3 domain of DOCK2. | Solution structure of the SH3 domain of DOCK180.
Liu X, Li F, Pan Z, Wang W, Wen W. | 09/21/2013 |
| DOCK1-Rac signaling as an HER2 effector pathway essential for HER2-mediated breast cancer progression to metastasis. | Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.
Laurin M, Huber J, Pelletier A, Houalla T, Park M, Fukui Y, Haibe-Kains B, Muller WJ, Côté JF., Free PMC Article | 06/29/2013 |
| Phosphorylation of Dock180(Y1811) enhanced its association with CrkII & p130(Cas). Dock180 associated with PDGFRalpha to promote cell migration. Phosphorylated Dock180(Y1811) contributes to activation of Rac1 in human cancers with PDGFRA amplification. | Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans.
Feng H, Hu B, Liu KW, Li Y, Lu X, Cheng T, Yiin JJ, Lu S, Keezer S, Fenton T, Furnari FB, Hamilton RL, Vuori K, Sarkaria JN, Nagane M, Nishikawa R, Cavenee WK, Cheng SY., Free PMC Article | 11/24/2012 |