| Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1. | Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1.
Xu DH, Du JK, Liu SY, Zhang H, Yang L, Zhu XY, Liu YJ., Free PMC Article | 04/21/2023 |
| Neural Cell Adhesion Molecule Regulates Osteoblastic Differentiation Through Wnt/beta-Catenin and PI3K-Akt Signaling Pathways in MC3T3-E1 Cells. | Neural Cell Adhesion Molecule Regulates Osteoblastic Differentiation Through Wnt/β-Catenin and PI3K-Akt Signaling Pathways in MC3T3-E1 Cells.
Cheng BF, Feng X, Gao YX, Jian SQ, Liu SR, Wang M, Xie YF, Wang L, Feng ZW, Yang HJ., Free PMC Article | 01/22/2022 |
| Polysialylated - neural cell adhesion molecule (PSA-NCAM) promotes recovery of vision after the critical period. | Polysialylated - neural cell adhesion molecule (PSA-NCAM) promotes recovery of vision after the critical period.
Luke MP, Brown RE, Clarke DB. | 07/31/2021 |
| Combinational Analyses with Multiple Methods Reveal the Existence of Several Forms of Polysialylated Neural Cell Adhesion Molecule in Mouse Developing Brains. | Combinational Analyses with Multiple Methods Reveal the Existence of Several Forms of Polysialylated Neural Cell Adhesion Molecule in Mouse Developing Brains.
Mori A, Yang Y, Takahashi Y, Hane M, Kitajima K, Sato C., Free PMC Article | 02/20/2021 |
| Authors demonstrate that neural cell adhesion molecule 1 (NCAM1) is one of the molecules involved and show that it mediates spine reorganization and contributes to the behavioral sensitization. | Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury.
Ko HG, Choi JH, Park DI, Kang SJ, Lim CS, Sim SE, Shim J, Kim JI, Kim S, Choi TH, Ye S, Lee J, Park P, Kim S, Do J, Park J, Islam MA, Kim HJ, Turck CW, Collingridge GL, Zhuo M, Kaang BK. | 07/13/2019 |
| CD56(neg) Natural Killer cells constitute functionally competent cells sharing many features of bona fide CD56(dim) Natural Killer cells in healthy individuals, but with some distinct characteristics. | Proteome analysis of human CD56(neg) NK cells reveals a homogeneous phenotype surprisingly similar to CD56(dim) NK cells.
Voigt J, Malone DFG, Dias J, Leeansyah E, Björkström NK, Ljunggren HG, Gröbe L, Klawonn F, Heyner M, Sandberg JK, Jänsch L. | 03/9/2019 |
| PrP and ZIP6 inherited the ability to interact with NCAM1 from their common ZIP ancestors but have since diverged to control distinct posttranslational modifications of NCAM1. | A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.
Brethour D, Mehrabian M, Williams D, Wang X, Ghodrati F, Ehsani S, Rubie EA, Woodgett JR, Sevalle J, Xi Z, Rogaeva E, Schmitt-Ulms G., Free PMC Article | 10/20/2018 |
| the effect of NCAM on tyrosine phosphorylation of beta1 integrin was independent of the fibroblast growth factor receptor. These results indicated that NCAM regulates directional lamellipodia formation of BMSCs through beta1 integrin signal-mediated cofilin activity. | NCAM affects directional lamellipodia formation of BMSCs via β1 integrin signal-mediated cofilin activity.
Bi JJ, Li J, Cheng BF, Yang HJ, Ding QQ, Wang RF, Chen SJ, Feng ZW. | 07/14/2018 |
| inhibiting NCAM1 would be cardioprotective, counteract the pathological action of TGFbeta1 and reduce heart failure severity. | TGF-β1 affects cell-cell adhesion in the heart in an NCAM1-dependent mechanism.
Ackermann MA, Petrosino JM, Manring HR, Wright P, Shettigar V, Kilic A, Janssen PML, Ziolo MT, Accornero F., Free PMC Article | 06/9/2018 |
| NCAM deletion in young adult mice reduces recovery after spinal cord injury. | Impact of neural cell adhesion molecule deletion on regeneration after mouse spinal cord injury.
Saini V, Loers G, Kaur G, Schachner M, Jakovcevski I. | 12/23/2017 |
| the neural cell adhesion molecule NCAM is co-expressed and directly interacts with GFRalpha1 in embryonic Purkinje cells. | GFRα1 Regulates Purkinje Cell Migration by Counteracting NCAM Function.
Sergaki MC, Ibáñez CF., Free PMC Article | 11/25/2017 |
| Increased polysialylation of the NCAM has been found in a transgenic mouse model of sialuria. | Increased Polysialylation of the Neural Cell Adhesion Molecule in a Transgenic Mouse Model of Sialuria.
Kreuzmann D, Horstkorte R, Kohla G, Kannicht C, Bennmann D, Thate A, Bork K. | 07/15/2017 |
| study delineates a mechanism in which NCAM promotes ephrin-A5-dependent clustering of EphA3 through interaction of the NCAM Ig2 domain and the EphA3 CRD, stimulating EphA3 autophosphorylation and RhoA signaling necessary for growth cone repulsion in GABAergic interneurons in vitro, which may extend to remodeling of axonal terminals of interneurons in vivo. | The Neural Cell Adhesion Molecule (NCAM) Promotes Clustering and Activation of EphA3 Receptors in GABAergic Interneurons to Induce Ras Homolog Gene Family, Member A (RhoA)/Rho-associated protein kinase (ROCK)-mediated Growth Cone Collapse.
Sullivan CS, Kümper M, Temple BS, Maness PF., Free PMC Article | 06/3/2017 |
| data provided molecular details about the interaction between HuPrP and the NCAM fibronectin domain, and revealed a new role of PrP(C) N terminus as a dynamic and functional element responsible for protein-protein interaction. | The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain.
Slapšak U, Salzano G, Amin L, Abskharon RN, Ilc G, Zupančič B, Biljan I, Plavec J, Giachin G, Legname G., Free PMC Article | 05/27/2017 |
| Results demonstrate that the early development of calbindin-positive periglomerular interneurons depends on the presentation of polysialic acid on NCAM and requires the activity of both St8sia2 and St8sia4 | Deficits of olfactory interneurons in polysialyltransferase- and NCAM-deficient mice.
Röckle I, Hildebrandt H. | 12/17/2016 |
| NCAM plays significant roles in the adult visual system in establishing normal retinal anatomy, physiology and function, and in maintaining vision during aging. | Effect of NCAM on aged-related deterioration in vision.
Luke MP, LeVatte TL, O'Reilly AM, Smith BJ, Tremblay F, Brown RE, Clarke DB. | 12/17/2016 |
| induced expression of L1CAM or PSA-NCAM in the iPSC-derived DA neurons cannot completely restore the neurite outgrowth potential that was reduced in these DA neurons as a consequence of epigenetic aberrations resulting from the iPSC reprogramming process. | Effect of Cell Adhesion Molecules on the Neurite Outgrowth of Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons.
Peng SP, Schachner M, Boddeke E, Copray S. | 12/17/2016 |
| The data of this study demonstrated the importance of NCAM for the development and functional activity of the BDNF signaling and serotonergic neurotransmission | NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline.
Aonurm-Helm A, Anier K, Zharkovsky T, Castrén E, Rantamäki T, Stepanov V, Järv J, Zharkovsky A. | 10/8/2016 |
| PrP-deficient cells fail to undergo NCAM1 polysialylation during EMT. | The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis.
Mehrabian M, Brethour D, Wang H, Xi Z, Rogaeva E, Schmitt-Ulms G., Free PMC Article | 05/14/2016 |
| NCAM-140 significantly promoted cell proliferation, motility and migration, while polysialylation of NCAM-140 catalyzed by STX, but not by PST, enhanced NCAM-mediated cell migration, but not cell proliferation or motility. | Promotion of cell migration by neural cell adhesion molecule (NCAM) is enhanced by PSA in a polysialyltransferase-specific manner.
Guan F, Wang X, He F., Free PMC Article | 04/16/2016 |
| changes of NCAM expression in the late postnatal and mature forebrain determine avoidance behaviour and serotonin (5-HT)1A receptor signalling. | NCAM deficiency in the mouse forebrain impairs innate and learned avoidance behaviours.
Brandewiede J, Stork O, Schachner M. | 03/26/2016 |
| Dicer ablation in the early metanephric mesenchyme results in severe renal dysgenesis despite normal initial specification of nephron progenitors and ureteric bud outgrowth. | Dicer function is required in the metanephric mesenchyme for early kidney development.
Chu JY, Sims-Lucas S, Bushnell DS, Bodnar AJ, Kreidberg JA, Ho J., Free PMC Article | 09/22/2015 |
| The molecular clock governs rhythmic ncam1 alpha1-2-fucosylation in secondary olfactory neurons. | Molecular clock regulates daily α1-2-fucosylation of the neural cell adhesion molecule (NCAM) within mouse secondary olfactory neurons.
Kondoh D, Tateno H, Hirabayashi J, Yasumoto Y, Nakao R, Oishi K., Free PMC Article | 04/18/2015 |
| PrP plays a critical role in neuronal differentiation of neuralprecursor cells and suggest that this function is, at least in part, NCAM-dependent. | Functional cross-talk between the cellular prion protein and the neural cell adhesion molecule is critical for neuronal differentiation of neural stem/precursor cells.
Prodromidou K, Papastefanaki F, Sklaviadis T, Matsas R. | 01/10/2015 |
| This study propose that presynaptic NCAM bridges a critical link between the SV cycle and the functional expansion of synaptic territory through the regulation of L-VDCCs. | Presynaptic NCAM is required for motor neurons to functionally expand their peripheral field of innervation in partially denervated muscles.
Chipman PH, Schachner M, Rafuse VF., Free PMC Article | 10/4/2014 |