| Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation. | Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation.
Maurya VK, Szwarc MM, Lonard DM, Kommagani R, Wu SP, O'Malley BW, DeMayo FJ, Lydon JP., | 11/18/2023 |
| Ncoa2 Promotes CD8+ T cell-Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1alpha Critical for Mitochondrial Function. | Ncoa2 Promotes CD8+ T cell-Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function.
Zhong X, Wu H, Ouyang C, Zhang W, Shi Y, Wang YC, Ann DK, Gwack Y, Shang W, Sun Z., Free PMC Article | 10/28/2023 |
| HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice. | HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice.
Tanaka M, Homme M, Teramura Y, Kumegawa K, Yamazaki Y, Yamashita K, Osato M, Maruyama R, Nakamura T., Free PMC Article | 05/30/2023 |
| SRC2 controls CD4[+] T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5. | SRC2 controls CD4(+) T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5.
Zhang W, Cao X, Zhong X, Wu H, Shi Y, Feng M, Wang YC, Ann D, Gwack Y, Yuan YC, Shang W, Sun Z., Free PMC Article | 04/26/2023 |
| NCOA2 coordinates with the transcriptional KAT2B-NF-kappaB partner to trigger inflammation response in acute kidney injury. | NCOA2 coordinates with the transcriptional KAT2B-NF-κB partner to trigger inflammation response in acute kidney injury.
Zhou P, Li D, Luo F, Wan X. | 06/11/2022 |
| Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition. | Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition.
Yang Y, He Y, Liu H, Zhou W, Wang C, Xu P, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Fukuda M, Tong Q, Xu J, Sun Z, O'Malley BW, Xu Y., Free PMC Article | 02/19/2022 |
| Transcription cofactor GRIP1 differentially affects myeloid cell-driven neuroinflammation and response to IFN-beta therapy. | Transcription cofactor GRIP1 differentially affects myeloid cell-driven neuroinflammation and response to IFN-β therapy.
Mimouna S, Rollins DA, Shibu G, Tharmalingam B, Deochand DK, Chen X, Oliver D, Chinenov Y, Rogatsky I., Free PMC Article | 09/18/2021 |
| Results suggest that SRC-2 coordinates cardiomyocyte secretion of VEGF downstream of the two major angiogenic stimuli occurring during pressure overload bridging both hypertrophic and hypoxia-stimulated paracrine signaling. | Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis.
Suh JH, Lai L, Nam D, Kim J, Jo J, Taffet GE, Kim E, Kaelber JT, Lee HK, Entman ML, Cooke JP, Reineke EL., Free PMC Article | 12/1/2018 |
| studies demonstrate that SRC-2 provides an essential link between the behavioral activities influenced by light cues and the metabolic homeostasis maintained by the liver | Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology.
Fleet T, Stashi E, Zhu B, Rajapakshe K, Marcelo KL, Kettner NM, Gorman BK, Coarfa C, Fu L, O'Malley BW, York B., Free PMC Article | 12/23/2017 |
| the expression of MOZ-TIF2 fusion protein represses the transcription of p16INK4a and p19ARF and blocks senescence. | Expression of the MOZ-TIF2 oncoprotein in mice represses senescence.
Largeot A, Perez-Campo FM, Marinopoulou E, Lie-a-Ling M, Kouskoff V, Lacaud G., Free PMC Article | 08/6/2016 |
| findings position SRC-2 as a major regulator of polygenic inputs to metabolic gene regulation and perhaps identify a previously unappreciated model that helps to explain the clinical spectrum of glucose dysregulation | SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis.
Fleet T, Zhang B, Lin F, Zhu B, Dasgupta S, Stashi E, Tackett B, Thevananther S, Rajapakshe KI, Gonzales N, Dean A, Mao J, Timchenko N, Malovannaya A, Qin J, Coarfa C, DeMayo F, Dacso CC, Foulds CE, O'Malley BW, York B., Free PMC Article | 03/5/2016 |
| fetal lungs produce signals to initiate labor when mature, and SRC-1/-2-dependent production of SP-A and PAF is crucial for this process | Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition.
Gao L, Rabbitt EH, Condon JC, Renthal NE, Johnston JM, Mitsche MA, Chambon P, Xu J, O'Malley BW, Mendelson CR., Free PMC Article | 09/26/2015 |
| In a murine model, overexpression of NCoA2 in the prostate epithelium resulted in neoplasia. | Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer.
Qin J, Lee HJ, Wu SP, Lin SC, Lanz RB, Creighton CJ, DeMayo FJ, Tsai SY, Tsai MJ., Free PMC Article | 03/7/2015 |
| the PAX3-NCOA2 fusion gene has a dual role in the tumorigenesis of rhabdomyosarcoma | PAX3-NCOA2 fusion gene has a dual role in promoting the proliferation and inhibiting the myogenic differentiation of rhabdomyosarcoma cells.
Yoshida H, Miyachi M, Sakamoto K, Ouchi K, Yagyu S, Kikuchi K, Kuwahara Y, Tsuchiya K, Imamura T, Iehara T, Kakazu N, Hojo H, Hosoi H. | 02/7/2015 |
| Transcription factor 23 (Tcf23), a basic-helix-loop-helix transcription factor, is a new progesterone-induced target gene that requires SRC-2 for full induction. | A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells.
Kommagani R, Szwarc MM, Kovanci E, Creighton CJ, O'Malley BW, Demayo FJ, Lydon JP., Free PMC Article | 11/22/2014 |
| SRC-2 is a transcriptional coactivator for BMAL1:CLOCK. Ablation of SRC-2 disrupts the central clock. | SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm.
Stashi E, Lanz RB, Mao J, Michailidis G, Zhu B, Kettner NM, Putluri N, Reineke EL, Reineke LC, Dasgupta S, Dean A, Stevenson CR, Sivasubramanian N, Sreekumar A, Demayo F, York B, Fu L, O'Malley BW., Free PMC Article | 11/8/2014 |
| SRC-2 is critical to transcriptional control modulated by MEF2, GATA-4, and Tbx5, thereby enhancing gene expression associated with cardiac growth. | Steroid receptor coactivator-2 is a dual regulator of cardiac transcription factor function.
Reineke EL, Benham A, Soibam B, Stashi E, Taegtmeyer H, Entman ML, Schwartz RJ, O'Malley BW., Free PMC Article | 10/11/2014 |
| SRC2 regulates anxiety response with SRC2(-/-) females showing decreased anxiety in novel environments. | Research resource: loss of the steroid receptor coactivators confers neurobehavioral consequences.
Stashi E, Wang L, Mani SK, York B, O'Malley BW., Free PMC Article | 04/26/2014 |
| Our results indicate that SRC-2 is involved in maintenance of the steady-state adult heart transcriptional profile, with its ablation inducing transcriptional changes that mimic a stressed heart. | SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart.
Reineke EL, York B, Stashi E, Chen X, Tsimelzon A, Xu J, Newgard CB, Taffet GE, Taegtmeyer H, Entman ML, O'Malley BW., Free PMC Article | 06/29/2013 |
| Deletion of Ncoa2/Src-2 in mice predisposes to diethylnitrosamine-induced liver tumorigenesis. | A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.
O'Donnell KA, Keng VW, York B, Reineke EL, Seo D, Fan D, Silverstein KA, Schrum CT, Xie WR, Mularoni L, Wheelan SJ, Torbenson MS, O'Malley BW, Largaespada DA, Boeke JD., Free PMC Article | 08/4/2012 |
| SRC-1 and TIF2 can modulate the expression of the uncoupling protein 3 in an antagonistic manner and that enhanced SRC-1 levels in TIF2-deficient myofibers are critically involved in the metabolic changes of TIF2(i)skm-/- mice. | The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.
Duteil D, Chambon C, Ali F, Malivindi R, Zoll J, Kato S, Geny B, Chambon P, Metzger D., Free PMC Article | 03/12/2011 |
| Pre-treatment with T0901317 before LPS stimulation can suppress the expressions of IRF3 and GRIP1 to inhibit inflammation and Kupffer cell activation. | [Liver X receptor alpha inhibits LPS-induced inflammation by down-regulating IFR3 and GRIP1 in mouse Kupffer cells].
Ou ZB, Huang QY, Sun K, Wei SD, Gong JP, Tu B. | 05/10/2010 |
| analysis of the skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2 | Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2.
Mödder UI, Monroe DG, Fraser DG, Spelsberg TC, Rosen CJ, Géhin M, Chambon P, O'Malley BW, Khosla S., Free PMC Article | 01/21/2010 |
| VDR and coactivators SRC2 and SRC3, which are also involved in other nuclear receptors as well, are critical for epidermis-specific sphingolipid production and barrier formation | Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation.
Oda Y, Uchida Y, Moradian S, Crumrine D, Elias PM, Bikle DD., Free PMC Article | 01/21/2010 |
| ER beta, AIB1, and TIF2 appear to be involved in colorectal tumorigenesis and might have prognostic significance. | Estrogen receptor alpha/beta, AIB1, and TIF2 in colorectal carcinogenesis: do coregulators have prognostic significance?
Grivas PD, Tzelepi V, Sotiropoulou-Bonikou G, Kefalopoulou Z, Papavassiliou AG, Kalofonos H. | 01/21/2010 |