| Molecular dynamics studies of CED-4/CED-9/EGL-1 ternary complex reveal CED-4 release mechanism in the linear apoptotic pathway of Caenorhabditis elegans. | Molecular dynamics studies of CED-4/CED-9/EGL-1 ternary complex reveal CED-4 release mechanism in the linear apoptotic pathway of Caenorhabditis elegans.
Reddy CN, Sankararamakrishnan R. | 04/6/2023 |
| Loss of egli-1, the Caenorhabditis elegans Orthologue of a Downstream Target of SMN, Leads to Abnormalities in Sensorimotor Integration. | Loss of egli-1, the Caenorhabditis elegans Orthologue of a Downstream Target of SMN, Leads to Abnormalities in Sensorimotor Integration.
Da Silva JD, Oliveira S, Pereira-Sousa J, Teixeira-Castro A, Costa MD, Maciel P. | 12/5/2020 |
| only 1mM DEM caused upregulation of egl-1, a gene controlled by a p53-orthologue, CEP-1.we suppressed GSH biosynthesis in worms by attenuating g-glutamylcysteine synthetase (gcs-1) expression through RNAi.gcs-1 knockdown commencing right after hatching impaired nematode stress resistance and rendered young adult worms prone to vulval ruptures during egg-laying. | Non-linear impact of glutathione depletion on C. elegans life span and stress resistance.
Urban N, Tsitsipatis D, Hausig F, Kreuzer K, Erler K, Stein V, Ristow M, Steinbrenner H, Klotz LO., Free PMC Article | 11/26/2017 |
| A protein interaction cascade involving EGL-1, CED-9, CED-4, and CED-3 results in the activation of the key cell death protease CED-3, which is tightly controlled by multiple positive and negative regulators. | Programmed Cell Death During Caenorhabditis elegans Development.
Conradt B, Wu YC, Xue D., Free PMC Article | 05/27/2017 |
| LIN-1 binds to, and activates transcription of, the key pro-apoptotic gene egl-1. Our results provide the first evidence that EGF induces PCD at the whole organism level and reveal the molecular basis for the death-promoting function of LIN-3/EGF | LIN-3/EGF promotes the programmed cell death of specific cells in Caenorhabditis elegans by transcriptional activation of the pro-apoptotic gene egl-1.
Jiang HS, Wu YC., Free PMC Article | 11/21/2015 |
| The transcriptional upregulation of egl-1 in the CEMs in hermaphrodites is necessary, but not sufficient for their death. | Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons.
Nehme R, Grote P, Tomasi T, Löser S, Holzkamp H, Schnabel R, Conradt B., Free PMC Article | 10/30/2010 |
| EGL-1 triggers apoptosis induction predominantly by antagonizing the function of an anti-apoptotic member of the core BCL-2 family. Review. | egl-1: a key activator of apoptotic cell death in C. elegans.
Nehme R, Conradt B. | 01/21/2010 |
| Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans. | Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans.
Breckenridge DG, Kang BH, Xue D., Free PMC Article | 01/21/2010 |
| Data show that the worm protein EGL-1 binds mammalian pro-survival proteins very poorly, but can be converted into a high-affinity ligand for Bcl-2 and Bcl-x(L) by mutation of the cysteine residue at position 62 within the BH3 domain. | EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency.
Lee EF, Chen L, Yang H, Colman PM, Huang DC, Fairlie WD. | 01/21/2010 |
| the binding of EGL-1 to CED-9 is extremely stable | Unique structural features of a BCL-2 family protein CED-9 and biophysical characterization of CED-9/EGL-1 interactions.
Woo JS, Jung JS, Ha NC, Shin J, Kim KH, Lee W, Oh BH. | 01/21/2010 |
| A complex between MAB-5 and the Pbx homolog CEH-20 directly regulates transcription of the BH3 domain gene egl-1 to initiate programmed cell death | Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1.
Liu H, Strauss TJ, Potts MB, Cameron S. | 01/21/2010 |
| Consistent with its ability to neutralize CED-9 function, EGL-1 antagonized CED-9-dependent remodeling of the mitochondrial network. | Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics.
Delivani P, Adrain C, Taylor RC, Duriez PJ, Martin SJ. | 01/21/2010 |
| oxidative, osmotic, heat shock and starvation stresses induce germ cell apoptosis through a p53 and EGL-1 independent pathway. | Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans.
Salinas LS, Maldonado E, Navarro RE. | 01/21/2010 |
| Metabolism of mutants of the proapoptotic EGL-1 protein was studied in a functional analysis of the CED-1 protein. | Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4.
Yan N, Gu L, Kokel D, Chai J, Li W, Han A, Chen L, Xue D, Shi Y. | 01/21/2010 |
| DNA damage increases expression of the proapoptotic gene egl-1, a response that requires hus-1 and the p53 homolog cep-1 | Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis.
Hofmann ER, Milstein S, Boulton SJ, Ye M, Hofmann JJ, Stergiou L, Gartner A, Vidal M, Hengartner MO. | 01/21/2010 |
| Lag-3 has a role in regulating p53-mediated germ cell apoptotic response to DNA damage and expression of Ced-13 and Egl-1, downstream pro-apoptotic targets of the C. elegans p53 homolog Cep-1 | The notch regulator MAML1 interacts with p53 and functions as a coactivator.
Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V. | 01/21/2010 |
| mitochondria fragment in cells that normally undergo programmed cell death during C. elegans development; fragmentation is induced by the BH3-only protein EGL-1 | DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans.
Jagasia R, Grote P, Westermann B, Conradt B. | 01/21/2010 |