| PUM2 promoted osteoarthritis progression through PTEN-mediated chondrocyte ferroptosis by facilitating NEDD4 mRNA degradation. | PUM2 promoted osteoarthritis progression through PTEN-mediated chondrocyte ferroptosis by facilitating NEDD4 mRNA degradation.
Meng Y, Chen L, Chai Y, Meng W, Yang G, Ren J, Li H, Qi P, Chen J, Wang N. | 09/16/2024 |
| The Role of Ubiquitination and the E3 Ligase Nedd4 in Regulating Corneal Epithelial Wound Healing. | The Role of Ubiquitination and the E3 Ligase Nedd4 in Regulating Corneal Epithelial Wound Healing.
Ling X, Xu W, Tang J, Cao Q, Luo G, Chen X, Yang S, Reinach PS, Yan D., Free PMC Article | 06/28/2024 |
| High glucose environment induces NEDD4 deficiency that impairs angiogenesis and diabetic wound healing. | High glucose environment induces NEDD4 deficiency that impairs angiogenesis and diabetic wound healing.
Guo Y, Wang Y, Liu H, Jiang X, Lei S. | 12/28/2023 |
| NEDD4 Regulated Pyroptosis Occurred from Co-infection between Influenza A Virus and Streptococcus pneumoniae. | NEDD4 Regulated Pyroptosis Occurred from Co-infection between Influenza A Virus and Streptococcus pneumoniae.
You J, Zhou L, San X, Li H, Li M, Wang B. | 11/7/2023 |
| Nedd4-1 regulates human sodium-dependent vitamin C transporter-2 functional expression in neuronal and epithelial cells. | Nedd4-1 regulates human sodium-dependent vitamin C transporter-2 functional expression in neuronal and epithelial cells.
Teafatiller T, Perez O, Kitazawa M, Agrawal A, Subramanian VS. | 09/15/2023 |
| MicroRNA-155-5p in serum derived-exosomes promotes ischaemia-reperfusion injury by reducing CypD ubiquitination by NEDD4. | MicroRNA-155-5p in serum derived-exosomes promotes ischaemia-reperfusion injury by reducing CypD ubiquitination by NEDD4.
Hu C, Liao J, Huang R, Su Q, He L., Free PMC Article | 03/30/2023 |
| Phosphorylation by IKKbeta Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer. | Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
Zhong C, Xiong G, Yang H, Du X, Du J, Yao F, Fang W, Deng Y., Free PMC Article | 03/21/2023 |
| NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis. | NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis.
Sun W, Lu H, Cui S, Zhao S, Yu H, Song H, Ruan Q, Zhang Y, Chu Y, Dong S., Free PMC Article | 02/11/2023 |
| p21-activated kinase 4 controls the aggregation of alpha-synuclein by reducing the monomeric and aggregated forms of alpha-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1. | p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1.
Won SY, Park JJ, You ST, Hyeun JA, Kim HK, Jin BK, McLean C, Shin EY, Kim EG., Free PMC Article | 07/9/2022 |
| NEDD4-1 Is a Key Regulator of Epidermal Homeostasis and Wound Repair. | NEDD4-1 Is a Key Regulator of Epidermal Homeostasis and Wound Repair.
Yan S, Ripamonti R, Kawabe H, Ben-Yehuda Greenwald M, Werner S. | 06/11/2022 |
| Loss of NEDD4 causes complete XY gonadal sex reversal in mice. | Loss of NEDD4 causes complete XY gonadal sex reversal in mice.
Windley SP, Mayère C, McGovern AE, Harvey NL, Nef S, Schwarz Q, Kumar S, Wilhelm D., Free PMC Article | 04/16/2022 |
| Dietary sodium modulates nephropathy in Nedd4-2-deficient mice. | Dietary sodium modulates nephropathy in Nedd4-2-deficient mice.
Manning JA, Shah SS, Henshall TL, Nikolic A, Finnie J, Kumar S., Free PMC Article | 09/11/2021 |
| Identification of novel interacting partners of the NEDD4 ubiquitin ligase in mouse testis. | Identification of novel interacting partners of the NEDD4 ubiquitin ligase in mouse testis.
Manning J, Windley SP, Sandow JJ, Shah SS, Western P, Wilhelm D, Kumar S. | 07/31/2021 |
| PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking. | PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking.
Hirata H, Xu X, Nishioka K, Matsuhisa F, Kitajima S, Kukita T, Murayama M, Urano Y, Miyamoto H, Mawatari M, Kukita A. | 06/26/2021 |
| E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation. | E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation.
Liu Q, Zhang S, Sun Z, Guo X, Zhou H., Free PMC Article | 09/12/2020 |
| NEDD4 enhances osteoblast proliferation by removing pSMAD1 activated by TGFbeta1. | E3-ubiquitin ligase NEDD4 enhances bone formation by removing TGFβ1-induced pSMAD1 in immature osteoblast.
Jeon SA, Lee JH, Kim DW, Cho JY. | 07/20/2019 |
| NEDD4 participates in killing of intracellular bacterial pathogens via autophagy by sustaining the stability of BECN1. | The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.
Pei G, Buijze H, Liu H, Moura-Alves P, Goosmann C, Brinkmann V, Kawabe H, Dorhoi A, Kaufmann SHE., Free PMC Article | 07/6/2019 |
| This study proved the regulation mechanism that lncRNA SNHG1 negatively regulates p38 MAPK signal pathway through ubiquitination mediated by Nedd4, and thus inhibits osteogenic differentiation of bone marrow mesenchymal stem cells. | LncRNA SNHG1 modulates p38 MAPK pathway through Nedd4 and thus inhibits osteogenic differentiation of bone marrow mesenchymal stem cells.
Jiang Y, Wu W, Jiao G, Chen Y, Liu H. | 06/29/2019 |
| NEDD4 targets an RNA-binding protein, NANOS2, in spermatogonia to destabilize it, leading to cell differentiation. A NEDD4-mediated mechanism regulates mRNP dynamics, and facilitates spermatogonial progenitor cell homeostasis and viability under normal and stress conditions. | NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes.
Zhou Z, Kawabe H, Suzuki A, Shinmyozu K, Saga Y., Free PMC Article | 12/22/2018 |
| these findings support NEDD4 as a novel regulator of adipogenesis by modulating the stability of PPARgamma. | Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells.
Li JJ, Wang R, Lama R, Wang X, Floyd ZE, Park EA, Liao FF., Free PMC Article | 06/9/2018 |
| expression or dysfunction of Nedd4 E3 ligase could be involved in vascular calcification of VSMCs by activating bone-forming signals during atherosclerosis progression | Nedd4 Deficiency in Vascular Smooth Muscle Promotes Vascular Calcification by Stabilizing pSmad1.
Lee JH, Jeon SA, Kim BG, Takeda M, Cho JJ, Kim DI, Kawabe H, Cho JY. | 02/17/2018 |
| Our data suggest that the behavioral sensitivity to stress is dramatically reduced in FXS, opening new views on the impact of gene-environment interactions in this pathology. | Behavioral effects of chronic stress in the Fmr1 mouse model for fragile X syndrome.
Lemaire-Mayo V, Subashi E, Henkous N, Beracochea D, Pietropaolo S. | 12/30/2017 |
| Nedd4-1 is required for efficient internalization of major growth factor receptors involved in liver regeneration and their downstream mitogenic signaling. | Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration.
Bachofner M, Speicher T, Bogorad RL, Muzumdar S, Derrer CP, Hürlimann F, Böhm F, Nanni P, Kockmann T, Kachaylo E, Meyer M, Padrissa-Altés S, Graf R, Anderson DG, Koteliansky V, Auf dem Keller U, Werner S. | 10/14/2017 |
| NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2 activation cascade. | NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.
Ando K, Parsons MJ, Shah RB, Charendoff CI, Paris SL, Liu PH, Fassio SR, Rohrman BA, Thompson R, Oberst A, Sidi S, Bouchier-Hayes L., Free PMC Article | 09/16/2017 |
| these results suggest that Nedd4 suppresses colonic WNT signaling and tumor growth, at least in part, by suppressing the transcription factors LEF1 and YY1. | Intestinal knockout of Nedd4 enhances growth of Apc(min) tumors.
Lu C, Thoeni C, Connor A, Kawabe H, Gallinger S, Rotin D. | 09/9/2017 |