| The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2[V617F] mutated cells. | The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2(V617F) mutated cells.
Staehle AM, Peeken JC, Vladimirov G, Hoeness ME, Bojtine Kovacs S, Karantzelis N, Gruender A, Koellerer C, Jutzi JS, Pahl HL, Staehle HF., Free PMC Article | 04/12/2023 |
| mutations in NFE2 predispose to the acquisition of secondary changes promoting the development of myelosarcoma and/or AML | Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations.
Jutzi JS, Basu T, Pellmann M, Kaiser S, Steinemann D, Sanders MA, Hinai ASA, Zeilemaker A, Bojtine Kovacs S, Koellerer C, Ostendorp J, Aumann K, Wang W, Raffoux E, Cassinat B, Bullinger L, Schlegelberger B, Valk PJM, Pahl HL., Free PMC Article | 12/28/2019 |
| We detected that cigarette smoke significantly increased p45 NFE2 levels in DJ-1 KO mice compared to wild-type mice. Our results indicate that p45 NFE2 expression is induced by exposure to cigarette smoke, has a cytoprotective activity against cell injury, and its downregulation in human primary ATII cells may contribute to emphysema pathogenesis | The cytoprotective role of DJ-1 and p45 NFE2 against human primary alveolar type II cell injury and emphysema.
Tan LH, Bahmed K, Lin CR, Marchetti N, Bolla S, Criner GJ, Kelsen S, Madesh M, Kosmider B., Free PMC Article | 09/14/2019 |
| Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 and either RUNX1, FLI1 or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation. | NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes.
Zang C, Luyten A, Chen J, Liu XS, Shivdasani RA., Free PMC Article | 04/21/2018 |
| Under the obese condition, activation of the hepatic NFE2/miR-423-5p axis plays important roles in the progression of type 2 diabetes and NAFLD by repressing the FAM3A-ATP-Akt signaling pathway. | NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway.
Yang W, Wang J, Chen Z, Chen J, Meng Y, Chen L, Chang Y, Geng B, Sun L, Dou L, Li J, Guan Y, Cui Q, Yang J. | 09/2/2017 |
| results suggest that Nrf2 deficiency induced by HFD promoted hepatic fatty acid metabolism disorder by altering 18-carbon and 22-carbon fatty acid composition | NF-E2-related factor 2 deletion facilitates hepatic fatty acids metabolism disorder induced by high-fat diet via regulating related genes in mice.
Wang X, Li C, Xu S, Ishfaq M, Zhang X. | 07/15/2017 |
| A novel murine model may excellently describe the deleterious impact of sustained chronic NF-E2 overexpression during uncontrolled chronic inflammation upon the hematopoietic system--the development of clonal myeloproliferation. | A role of NF-E2 in chronic inflammation and clonal evolution in essential thrombocythemia, polycythemia vera and myelofibrosis?
Hasselbalch HC. | 03/22/2014 |
| Although none of the parameters measured were different between the NF-E2 deficient and control mice, an increase in calcium (21%) and an increase in the mineral/matrix ratio (32%) was observed in GATA-1 deficient mice. | The effects of GATA-1 and NF-E2 deficiency on bone biomechanical, biochemical, and mineral properties.
Kacena MA, Gundberg CM, Kacena WJ 3rd, Landis WJ, Boskey AL, Bouxsein ML, Horowitz MC., Free PMC Article | 11/16/2013 |
| By activating genes in megakaryocytes that mediate platelet production and function, NF-E2 p45 determines the quantity and quality of platelets. | NF-E2 p45 is important for establishing normal function of platelets.
Fujita R, Takayama-Tsujimoto M, Satoh H, Gutiérrez L, Aburatani H, Fujii S, Sarai A, Bresnick EH, Yamamoto M, Motohashi H., Free PMC Article | 08/31/2013 |
| maintaining expression of intestinal epithelial cell prohibitin reduces the severity of inflammation and increases colonic levels of the antioxidants HO-1 and NQO-1 via a mechanism independent of Nfe2 | Nrf2 is not required for epithelial prohibitin-dependent attenuation of experimental colitis.
Kathiria AS, Butcher MA, Hansen JM, Theiss AL., Free PMC Article | 07/20/2013 |
| These findings demonstrate that a combination of p45NF-E2, Maf G, and Maf K is a key determinant of both megakaryopoiesis and thrombopoiesis. | Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf.
Ono Y, Wang Y, Suzuki H, Okamoto S, Ikeda Y, Murata M, Poncz M, Matsubara Y., Free PMC Article | 01/5/2013 |
| Loss of p45 NF-E2 leads to a 2-fold increase in serum erythropoietin & increased splenic erythropoiesis. Erythroid cells were arrested at the G(1) stage of cell cycle. | Abnormal differentiation of erythroid precursors in p45 NF-E2(-/-) mice.
Gasiorek JJ, Nouhi Z, Blank V. | 06/16/2012 |
| Nfe2 modulates JunD binding to the Gcm1 promoter via acetylation | Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation.
Kashif M, Hellwig A, Hashemolhosseini S, Kumar V, Bock F, Wang H, Shahzad K, Ranjan S, Wolter J, Madhusudhan T, Bierhaus A, Nawroth P, Isermann B., Free PMC Article | 04/14/2012 |
| studies identify a novel function of p45NF-E2 during placental development: in trophoblast cells, p45NF-E2 represses Gcm1 and syncytiotrophoblast formation via acetylation | p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth.
Kashif M, Hellwig A, Kolleker A, Shahzad K, Wang H, Lang S, Wolter J, Thati M, Vinnikov I, Bierhaus A, Nawroth PP, Isermann B. | 07/23/2011 |
| NLS-dependent nuclear import of p45 NF-E2 is important for platelet development | A monopartite sequence is essential for p45 NF-E2 nuclear translocation, transcriptional activity and platelet production.
Perdomo J, Fock EL, Kaur G, Yan F, Khachigian LM, Jans DA, Chong BH. | 05/28/2011 |
| USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus. | USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus.
Zhou Z, Li X, Deng C, Ney PA, Huang S, Bungert J., Free PMC Article | 06/28/2010 |
| Data suggest that GATA1 or other factors regulated by GATA1 are required to cooperate with p45 for normal megakaryopoiesis. | Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis.
Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, Motohashi H, Yamamoto M., Free PMC Article | 06/14/2010 |
| Data suggest that the posttranslational modifications and turnover of p45/NF-E2, as mediated by P-JNK, contribute to the control of its homeostatic concentration and consequently, its regulatory functions. | JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells.
Lee TL, Shyu YC, Hsu PH, Chang CW, Wen SC, Hsiao WY, Tsai MD, Shen CK., Free PMC Article | 03/15/2010 |
| Globin gene activation by heme appears to be independent of the putative heme regulatory motifs in the p45 subunit of the NF-E2 transcription factor.(p45 NF-E2) | Regulation of globin gene transcription by heme in erythroleukemia cells: analysis of putative heme regulatory motifs in the p45 NF-E2 transcription factor.
Moore A, Merad Boudia M, Lehalle D, Massrieh W, Derjuga A, Blank V. | 01/21/2010 |
| Knockout mice are more susceptible to skin tumorigenesis and chemopreventive effects of sulforaphane are mediated, at least in part, through Nrf2. | Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.
Xu C, Huang MT, Shen G, Yuan X, Lin W, Khor TO, Conney AH, Kong AN. | 01/21/2010 |
| hematopoietic-specific activators NF-E2 and GATA-1, which mediate transactivation of the beta-globin genes, induce both histone acetylation and H3-meK4 | Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain.
Kiekhaefer CM, Grass JA, Johnson KD, Boyer ME, Bresnick EH., Free PMC Article | 01/21/2010 |
| Scl acts up-stream of NF-E2 expression to control megakaryocyte development and platelet release in settings of thrombopoietic stress | A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis.
McCormack MP, Hall MA, Schoenwaelder SM, Zhao Q, Ellis S, Prentice JA, Clarke AJ, Slater NJ, Salmon JM, Jackson SP, Jane SM, Curtis DJ., Free PMC Article | 01/21/2010 |
| Cells of the osteoblast lineage do not express NF-E2 mRNA. A megakaryocyte-osteoblast interaction occurs in NF-E2- deficient mice which is anabolic for bone. | Loss of the transcription factor p45 NF-E2 results in a developmental arrest of megakaryocyte differentiation and the onset of a high bone mass phenotype.
Kacena MA, Gundberg CM, Nelson T, Horowitz MC. | 01/21/2010 |
| Transactivation studies and chromatin immunoprecipitation implicate Lims1 as a direct target of NF-E2 regulation | Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2.
Chen Z, Hu M, Shivdasani RA., Free PMC Article | 01/21/2010 |
| Chromatin immunoprecipitation demonstrates recruitment of NF-E2 to the putative Rab27B promoter | A role for Rab27b in NF-E2-dependent pathways of platelet formation.
Tiwari S, Italiano JE Jr, Barral DC, Mules EH, Novak EK, Swank RT, Seabra MC, Shivdasani RA. | 01/21/2010 |