| Islet transplantation into brown adipose tissue can delay immune rejection. | Islet transplantation into brown adipose tissue can delay immune rejection.
Kepple JD, Barra JM, Young ME, Hunter CS, Tse HM., Free PMC Article | 04/2/2022 |
| Nkx6.1 enhances neural stem cell activation and attenuates glial scar formation and neuroinflammation in the adult injured spinal cord. | Nkx6.1 enhances neural stem cell activation and attenuates glial scar formation and neuroinflammation in the adult injured spinal cord.
Patel M, Anderson J, Lei S, Finkel Z, Rodriguez B, Esteban F, Risman R, Li Y, Lee KB, Lyu YL, Cai L., Free PMC Article | 12/25/2021 |
| Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation. | Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation.
Zhang FF, Liu YH, Wang DW, Liu TS, Yang Y, Guo JM, Pan Y, Zhang YF, Du H, Li L, Jin L. | 04/3/2021 |
| our data reveal a novel mechanism of Notch1 transcriptional regulation in the ventral spinal cord by Nkx6.1 via its binding with Notch1 enhancer CR2 during embryonic development. | Transcriptional Regulation of Notch1 Expression by Nkx6.1 in Neural Stem/Progenitor Cells during Ventral Spinal Cord Development.
Li Y, Tzatzalos E, Kwan KY, Grumet M, Cai L., Free PMC Article | 06/9/2018 |
| Nkx6.1 plays a vital role in astrocyte specification and differentiation in the ventral spinal cord. | Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.
Zhao X, Chen Y, Zhu Q, Huang H, Teng P, Zheng K, Hu X, Xie B, Zhang Z, Sander M, Qiu M., Free PMC Article | 06/20/2015 |
| MAFA, MAFB, NKX6.1, and PDX1 activity provides a gauge of islet beta cell function, with loss of MAFA (and/or MAFB) representing an early indicator of beta cell inactivity | Inactivation of specific β cell transcription factors in type 2 diabetes.
Guo S, Dai C, Guo M, Taylor B, Harmon JS, Sander M, Robertson RP, Powers AC, Stein R., Free PMC Article | 07/12/2014 |
| Over time, Nkx6.1-deficient beta cells acquired molecular characteristics of delta cells, revealing a molecular link between impaired beta cell functional properties and loss of cell identity. | Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells.
Taylor BL, Liu FF, Sander M., Free PMC Article | 06/28/2014 |
| Our findings establish Nkx6.1 as a beta cell programming factor and demonstrate that repression of alternative lineage programs is a fundamental principle by which beta cells are specified and maintained. | Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.
Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M., Free PMC Article | 06/1/2013 |
| Data found direct binding of RBP-jkappa to the Nkx6.1 proximal promoter. | Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells.
Afelik S, Qu X, Hasrouni E, Bukys MA, Deering T, Nieuwoudt S, Rogers W, Macdonald RJ, Jensen J., Free PMC Article | 06/9/2012 |
| Results demonstrate that sustained Nkx6.1 overexpression in vivo does not stimulate beta-cell proliferation, expand beta-cell mass, or improve glucose metabolism in either normal or beta-cell-depleted pancreata. | Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.
Schaffer AE, Yang AJ, Thorel F, Herrera PL, Sander M., Free PMC Article | 05/19/2012 |
| Nkx6 genes pattern the frog neural plate and Nkx6.1 is necessary for motoneuron axon projection. | Nkx6 genes pattern the frog neural plate and Nkx6.1 is necessary for motoneuron axon projection.
Dichmann DS, Harland RM., Free PMC Article | 02/26/2011 |
| Data show a longitudinal domain positive for both Nkx6.1 and Nkx6.2 that is medial to the Pou4f1-positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon. | Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes-diencephalic basal plate.
Moreno-Bravo JA, Perez-Balaguer A, Martinez S, Puelles E. | 09/27/2010 |
| The homeodomain transcription factor Nkx6-1 controls the proper development of the red nucleus and of the oculomotor and trochlear nucleus neurons. | Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain.
Prakash N, Puelles E, Freude K, Trümbach D, Omodei D, Di Salvio M, Sussel L, Ericson J, Sander M, Simeone A, Wurst W., Free PMC Article | 01/21/2010 |
| Data show that subtype-restricted progenitors from the Nkx6.1+ region are present in the ventral spinal cord, although at a lower frequency than expected. | Heterogeneity in the developmental potential of motor neuron progenitors revealed by clonal analysis of single cells in vitro.
Agalliu D, Schieren I., Free PMC Article | 01/21/2010 |
| confocal analysis identifies an abundant triple-positive (Ptf1a(+)/Nkx6.1(+)/Pdx1(+)) putative early multipotent pancreatic progenitor cell that marks the e9.5 dorsal pancreas and e10.5 ventral pancreas. | Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development.
Hald J, Sprinkel AE, Ray M, Serup P, Wright C, Madsen OD., Free PMC Article | 01/21/2010 |
| Nkx6 proteins, a set of Hox-regulated homeodomain transcription factors, are expressed by motor pools soon after motor neurons leave the cell cycle, before the formation of muscle nerve side branches in the limb of mice. | Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity.
De Marco Garcia NV, Jessell TM., Free PMC Article | 01/21/2010 |
| distinct requirements for Nkx6.1 and Nkx6.2 in endocrine differentiation are a consequence of their divergent spatiotemporal expression domains rather than their biochemical activities | The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.
Nelson SB, Schaffer AE, Sander M. | 01/21/2010 |
| Nkx6.1 homeodomain neural progenitor gene is specifically expressed in the ventral neural tube, and its activity is required for motoneuron generation in the spinal cord. | Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor.
Liu R, Cai J, Hu X, Tan M, Qi Y, German M, Rubenstein J, Sander M, Qiu M. | 01/21/2010 |
| Nkx6.1 is a bifunctional transcription factor that serves to maintain the specific expression of its own gene during beta-cell differentiation while simultaneously effecting broader gene repression events | The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1.
Iype T, Taylor DG, Ziesmann SM, Garmey JC, Watada H, Mirmira RG. | 01/21/2010 |
| Results demonstrate a requirement for Nkx6.1 in the development of postmitotic motoneurons, and suggest a cell-autonomous function in the control of branchio-motoneuron migration. | Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons.
Müller M, Jabs N, Lorke DE, Fritzsch B, Sander M. | 01/21/2010 |
| Ependymal cells in adult spinal cord are derived from Nkx6.1+ ventral neural progenitor cells. Nkx6.1+ ependymal cells in adult mouse spinal cords may retain the proliferative property of neural stem cells. | Molecular mapping of the origin of postnatal spinal cord ependymal cells: evidence that adult ependymal cells are derived from Nkx6.1+ ventral neural progenitor cells.
Fu H, Qi Y, Tan M, Cai J, Hu X, Liu Z, Jensen J, Qiu M. | 01/21/2010 |
| Nkx6.1 is regulated by Nkx6.2; Nkx6.1 has distinct domains in the pancreas. | NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas.
Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M. | 01/21/2010 |