| Grainyhead-like 2 interacts with noggin to regulate tissue fusion in mouse. | Grainyhead-like 2 interacts with noggin to regulate tissue fusion in mouse.
de Vries ME, Carpinelli MR, Fuller JN, Sutton Y, Partridge DD, Auden A, Anderson PJ, Jane SM, Dworkin S., Free PMC Article | 02/29/2024 |
| Noggin, an inhibitor of bone morphogenetic protein signaling, antagonizes TGF-beta1 in a mouse model of osteoarthritis. | Noggin, an inhibitor of bone morphogenetic protein signaling, antagonizes TGF-β1 in a mouse model of osteoarthritis.
Wen L, Gao M, He Z, Guo P, Liu Z, Zhang P, Zhang F, Chen D, Zhou G, Zhou Z. | 11/22/2021 |
| Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcgammaR-Deficient Human IL-15 Transgenic Mouse. | Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse.
Katano I, Ito R, Kawai K, Takahashi T., Free PMC Article | 05/1/2021 |
| Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia. | Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia.
Pinzon-Guzman C, Sangadala S, Riera KM, Popova EY, Manning E, Huh WJ, Alexander MS, Shelton JS, Boden SD, Goldenring JR., Free PMC Article | 02/6/2021 |
| Noggin inhibition of mouse dentinogenesis. | Noggin inhibition of mouse dentinogenesis.
Jani P, Zhang H, Benson MD, Qin C., Free PMC Article | 08/22/2020 |
| Noggin depletion in adipocytes promotes obesity in mice. | Noggin depletion in adipocytes promotes obesity in mice.
Blázquez-Medela AM, Jumabay M, Rajbhandari P, Sallam T, Guo Y, Yao J, Vergnes L, Reue K, Zhang L, Yao Y, Fogelman AM, Tontonoz P, Lusis AJ, Wu X, Boström KI., Free PMC Article | 04/25/2020 |
| Noggin rescues age-related stem cell loss in the brain of senescent mice with abnormally increased BMP6 causing neurodegenerative pathology. | Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology.
Díaz-Moreno M, Armenteros T, Gradari S, Hortigüela R, García-Corzo L, Fontán-Lozano Á, Trejo JL, Mira H., Free PMC Article | 05/4/2019 |
| Noggin null mice display cutaneous syndactyly and impaired interdigital mesenchyme specification. Failure of webbing regression was caused by lack of cell cycle exit and interdigital apoptosis. Noggin null mutants have increased Indian hedgehog (Ihh) expression in cartilage condensations leading to aberrant extension of IHH downstream signaling into the interdigital mesenchyme. | Cooperation of BMP and IHH signaling in interdigital cell fate determination.
Murgai A, Altmeyer S, Wiegand S, Tylzanowski P, Stricker S., Free PMC Article | 12/22/2018 |
| Down-regulation of Noggin and miR-138 cooperatively promoted osteogenic differentiation of mesenchymal stem cells. | Down-regulation of Noggin and miR-138 coordinately promote osteogenesis of mesenchymal stem cells.
Sun XK, Zhou J, Zhang L, Ma T, Wang YH, Yang YM, Tang YT, Li H, Wang LJ. | 06/23/2018 |
| the absence of Noggin, and consequently BMP hypersignaling, leads to the decrease of the number of muscle progenitor cells and their phenotypic shift towards adipocytes in vitro. | Noggin inactivation affects the number and differentiation potential of muscle progenitor cells in vivo.
Costamagna D, Mommaerts H, Sampaolesi M, Tylzanowski P., Free PMC Article | 06/2/2018 |
| Bone morphogenetic protein signaling and its antagonism by NOGGIN play a role in osteoarthritis development. | Expression of Noggin and Gremlin1 and its implications in fine-tuning BMP activities in mouse cartilage tissues.
Yu X, Kawakami H, Tahara N, Olmer M, Hayashi S, Akiyama R, Bagchi A, Lotz M, Kawakami Y., Free PMC Article | 09/23/2017 |
| We demonstrate that elevated BMP4 depletes PSM progenitors in vitro, phenocopying the Fgf3 mutant, suggesting that excessive BMP signals cause the Fgf3 axis defect. To test this in vivo we increased BMP signaling in Fgf3 mutants by removing one copy of Noggin, which encodes a BMP antagonist. | An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension.
Anderson MJ, Schimmang T, Lewandoski M., Free PMC Article | 05/27/2017 |
| we observed a glial reaction and an activity-dependent modification of Shh, Noggin, and Numb proteins. we found that Shh and Noggin could affect motor performance and that these proteins could be associated with both TDP-43 and Numb | Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease.
Gulino R, Parenti R, Gulisano M., Free PMC Article | 03/12/2016 |
| Molecular analysis demonstrated that ectopic Noggin-expressing regions in the early heart's pacemaker region, failed to express the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Persistent Noggin arrests cardiomyocyte morphogenesis and results in early in utero lethality.
Simmons O, Snider P, Wang J, Schwartz RJ, Chen Y, Conway SJ., Free PMC Article | 11/21/2015 |
| endogenous Bmp2, Bmp4, and Noggin transcript levels in postnatal bone and cartilage mirrored the activity of their respective reporters in these tissues | Dynamics and cellular localization of Bmp2, Bmp4, and Noggin transcription in the postnatal mouse skeleton.
Pregizer SK, Mortlock DP., Free PMC Article | 07/25/2015 |
| A band of noggin-expressing cells insulates a region of proliferative chondrocytes from the influence of BMP signaling, allowing them to differentiate as articular cartilage upon exposure to Wnt signaling emanating from the interzone. | Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation.
Ray A, Singh PN, Sohaskey ML, Harland RM, Bandyopadhyay A., Free PMC Article | 05/23/2015 |
| Taken together, these results show that hair follicle development in Trps1 KO embryos is impaired directly or indirectly by decreased Noggin expression. | Trps1 deficiency inhibits the morphogenesis of secondary hair follicles via decreased Noggin expression.
Sun Y, Nakanishi M, Sato F, Oikawa K, Muragaki Y, Zhou G. | 03/21/2015 |
| BMP signaling was stimulated in adipose derived stem cells (ASCs) by downregulating noggin. | Enhanced osteogenesis of adipose derived stem cells with Noggin suppression and delivery of BMP-2.
Fan J, Park H, Tan S, Lee M., Free PMC Article | 01/24/2015 |
| The axial midline domain of Nog expression is critical to promote pharyngeal arch 1 development in early stages, necessary for adequate outgrowth of the mandibular bud. | Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton.
Matsui M, Klingensmith J., Free PMC Article | 09/20/2014 |
| Follistatin aids in maintaining proper somite size, and consequently sclerotome progenitor numbers, by preventing paraxial mesoderm from adopting an intermediate/lateral plate mesodermal fate in the Noggin-deficient state. | Follistatin interacts with Noggin in the development of the axial skeleton.
Stafford DA, Monica SD, Harland RM., Free PMC Article | 09/6/2014 |
| Noggin antagonizes BMP, which is required in presumptive notochord cells for mammalian foregut morphogenesis | BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis.
Fausett SR, Brunet LJ, Klingensmith J. | 06/28/2014 |
| Noggin is expressed constantly in Meckel's cartilage (MC) and in the absence of Noggin, MC is significantly thickened attributing to dramatically elevated cell proliferation rate associated with enhanced phosphorylation of Smad1/5/8. | Enhanced BMP signaling prevents degeneration and leads to endochondral ossification of Meckel's cartilage in mice.
Wang Y, Zheng Y, Chen D, Chen Y., Free PMC Article | 11/16/2013 |
| MiR-200c represses noggin in dental epithelial-like cells. | The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation.
Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus MT, Klein OD, Amendt BA., Free PMC Article | 10/19/2013 |
| Noggin stimulates myogenesis from dorsal aorta progenitors. | Noggin recruits mesoderm progenitors from the dorsal aorta to a skeletal myogenic fate.
Ugarte G, Cappellari O, Perani L, Pistocchi A, Cossu G., Free PMC Article | 06/29/2013 |
| Bone morphogenetic proteins and noggin have different roles in the processes of glial scar formation and neurorestoration in the ischemic brain. | Different temporal patterns in the expressions of bone morphogenetic proteins and noggin during astroglial scar formation after ischemic stroke.
Shin JA, Kang JL, Lee KE, Park EM. | 02/2/2013 |