| Transcriptome profiling of the Caenorhabditis elegans intestine reveals that ELT-2 negatively and positively regulates intestinal gene expression within the context of a gene regulatory network. | Transcriptome profiling of the Caenorhabditis elegans intestine reveals that ELT-2 negatively and positively regulates intestinal gene expression within the context of a gene regulatory network.
Williams RTP, King DC, Mastroianni IR, Hill JL, Apenes NW, Ramirez G, Miner EC, Moore A, Coleman K, Nishimura EO., Free PMC Article | 08/10/2023 |
| How affinity of the ELT-2 GATA factor binding to cis-acting regulatory sites controls Caenorhabditis elegans intestinal gene transcription. | How affinity of the ELT-2 GATA factor binding to cis-acting regulatory sites controls Caenorhabditis elegans intestinal gene transcription.
Lancaster BR, McGhee JD., Free PMC Article | 03/27/2021 |
| The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains. | The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains.
Zárate-Potes A, Yang W, Pees B, Schalkowski R, Segler P, Andresen B, Haase D, Nakad R, Rosenstiel P, Tetreau G, Colletier JP, Schulenburg H, Dierking K., Free PMC Article | 10/24/2020 |
| Study results indicate that C. elegans RPT-6 interacts with ELT-2 in vivo to control the expression of immune genes during response to Pseudomonas aeruginosa infection in a manner that is likely independent of the proteolytic activity of the proteasome. | Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection.
Olaitan AO, Aballay A., Free PMC Article | 01/19/2019 |
| gene loss leads to modest increases in the level of ELT-2 protein in the early endoderm although ELT-2 levels do not strictly correlate with rescue. | A Strategy To Isolate Modifiers of Caenorhabditis elegans Lethal Mutations: Investigating the Endoderm Specifying Ability of the Intestinal Differentiation GATA Factor ELT-2.
Wiesenfahrt T, Duanmu J, Snider F, Moerman D, Au V, Li-Leger E, Flibotte S, Parker DM, Marshall CJ, Nishimura EO, Mains PE, McGhee JD., Free PMC Article | 11/3/2018 |
| Genes expressed only in the intestine showed 3 distinguishable classes of response to different mutant backgrounds. One class of genes responded as if ELT-2 is the major transcriptional activator and ELT-7 provides variable compensatory input. Appropriately expressed ELT-2 is able to replace all other core GATA factors in the C. elegans endoderm. | Quantitating transcription factor redundancy: The relative roles of the ELT-2 and ELT-7 GATA factors in the C. elegans endoderm.
Dineen A, Osborne Nishimura E, Goszczynski B, Rothman JH, McGhee JD., Free PMC Article | 04/7/2018 |
| The authors determined that the GATA transcription factor ELT-2 and the p38 MAP kinase PMK-1 are necessary for animals to successfully recover from an acute Pseudomonas aeruginosa infection. | Role of GATA transcription factor ELT-2 and p38 MAPK PMK-1 in recovery from acute P. aeruginosa infection in C. elegans.
Head BP, Olaitan AO, Aballay A., Free PMC Article | 01/13/2018 |
| the C. elegans 44 bp enhancer from vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-beta/Sma/Mab pathway | A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-β/Sma/Mab pathway.
Goszczynski B, Captan VV, Danielson AM, Lancaster BR, McGhee JD. | 09/10/2016 |
| Overexpression of elt-2 extends lifespan and slows the rate of gene expression changes that occur during normal aging. Thus, our results identify the developmental regulator ELT-2 as a major driver of normal aging in C. elegans | Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans.
Mann FG, Van Nostrand EL, Friedland AE, Liu X, Kim SK., Free PMC Article | 08/27/2016 |
| GATA motifs played largely subtle roles in modulating postembryonic levels of elt-2 | Mutagenesis of GATA motifs controlling the endoderm regulator elt-2 reveals distinct dominant and secondary cis-regulatory elements.
Du L, Tracy S, Rifkin SA., Free PMC Article | 08/27/2016 |
| The rpn-10 mutant animals survive through the activation of compensatory mechanisms regulated by the conserved SKN-1/Nrf2 and ELT-2/GATA transcription factors that mediate the increased expression of genes encoding proteasome subunits. | Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway.
Keith SA, Maddux SK, Zhong Y, Chinchankar MN, Ferguson AA, Ghazi A, Fisher AL., Free PMC Article | 07/30/2016 |
| ELT-2 is capable of specifying the entire C. elegans endoderm. | The function and regulation of the GATA factor ELT-2 in the C. elegans endoderm.
Wiesenfahrt T, Berg JY, Osborne Nishimura E, Robinson AG, Goszczynski B, Lieb JD, McGhee JD., Free PMC Article | 07/16/2016 |
| These results suggest that ELT-2 functions as a tissue-specific master regulator controlling the contribution of the p38 MAPK pathway to innate immune responses. | The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult C. elegans.
Block DH, Twumasi-Boateng K, Kang HS, Carlisle JA, Hanganu A, Lai TY, Shapira M., Free PMC Article | 04/30/2016 |
| we found that recovery from an acute bacterial infection is dependent on ELT-2 activity. | Recovery from an acute infection in C. elegans requires the GATA transcription factor ELT-2.
Head B, Aballay A., Free PMC Article | 07/4/2015 |
| An unexpected feature of the transcriptional response to Burkholderia pseudomallei was a progressive increase in the proportion of down-regulated genes, of which ELT-2 transcriptional targets were significantly enriched. | Burkholderia pseudomallei suppresses Caenorhabditis elegans immunity by specific degradation of a GATA transcription factor.
Lee SH, Wong RR, Chin CY, Lim TY, Eng SA, Kong C, Ijap NA, Lau MS, Lim MP, Gan YH, He FL, Tan MW, Nathan S., Free PMC Article | 12/14/2013 |
| Intestinal distension is accelerated in elt-2 RNAi nematodes, and is observed in colonization but not toxin-based Pseudomonas infection. | Mode of bacterial pathogenesis determines phenotype in elt-2 and elt-7 RNAi Caenorhabditis elegans.
Elliott SL, Sturgeon CR, Travers DM, Montgomery MC. | 06/4/2011 |
| ELT-7 profoundly synergizes with ELT-2 to create a transcriptional switch essential for gut cell differentiation. | Endoderm development in Caenorhabditis elegans: the synergistic action of ELT-2 and -7 mediates the specification→differentiation transition.
Sommermann EM, Strohmaier KR, Maduro MF, Rothman JH., Free PMC Article | 11/27/2010 |
| the intestinal GATA transcription factor ELT-2 is required for both immunity to Salmonella enterica and expression of a C-type lectin gene, clec-67, which is expressed in the intestinal cells and is a good marker of S. enterica infection | GATA transcription factor required for immunity to bacterial and fungal pathogens.
Kerry S, TeKippe M, Gaddis NC, Aballay A., Free PMC Article | 03/22/2010 |
| Results suggest that ELT-2 plays a central role in most aspects of C. elegans intestinal physiology. | ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult.
McGhee JD, Fukushige T, Krause MW, Minnema SE, Goszczynski B, Gaudet J, Kohara Y, Bossinger O, Zhao Y, Khattra J, Hirst M, Jones SJ, Marra MA, Ruzanov P, Warner A, Zapf R, Moerman DG, Kalb JM., Free PMC Article | 01/21/2010 |
| Results present models by which ELT-2, PHA-4, and CdxA orchestrate expression from the internal promoter of tmy-1/lev-11. | Transcription factors GATA/ELT-2 and forkhead/HNF-3/PHA-4 regulate the tropomyosin gene expression in the pharynx and intestine of Caenorhabditis elegans.
Anokye-Danso F, Anyanful A, Sakube Y, Kagawa H. | 01/21/2010 |
| A simple model is proposed in which the ELT-2 GATA factor directly participates in the transcription of all intestine-specific/intestine-enriched genes, from the early embryo through to the dying adult. | The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine.
McGhee JD, Sleumer MC, Bilenky M, Wong K, McKay SJ, Goszczynski B, Tian H, Krich ND, Khattra J, Holt RA, Baillie DL, Kohara Y, Marra MA, Jones SJ, Moerman DG, Robertson AG. | 01/21/2010 |
| Results identify a conserved function for endodermal GATA transcription factors GATA6 and ELT-2 in regulating local epithelial innate immune responses. | A conserved role for a GATA transcription factor in regulating epithelial innate immune responses.
Shapira M, Hamlin BJ, Rong J, Chen K, Ronen M, Tan MW., Free PMC Article | 01/21/2010 |