| PTP-3 phosphatase promotes intramolecular folding of SYD-2 to inactivate kinesin-3 UNC-104 in neurons. | PTP-3 phosphatase promotes intramolecular folding of SYD-2 to inactivate kinesin-3 UNC-104 in neurons.
Muniesh MS, Barmaver SN, Huang HY, Bayansan O, Wagner OI., Free PMC Article | 07/31/2021 |
| Data reveal a new and unprecedented role for 2 synapse assembly proteins, SAD-1 and SYD-2, in mediating UNC-16's organelle transport regulatory function. | UNC-16 (JIP3) Acts Through Synapse-Assembly Proteins to Inhibit the Active Transport of Cell Soma Organelles to Caenorhabditis elegans Motor Neuron Axons.
Edwards SL, Morrison LM, Yorks RM, Hoover CM, Boominathan S, Miller KG., Free PMC Article | 06/28/2016 |
| N-terminal CC domains are responsible for the synaptogenic activity of SYD-2. | Intramolecular regulation of presynaptic scaffold protein SYD-2/liprin-α.
Chia PH, Patel MR, Wagner OI, Klopfenstein DR, Shen K., Free PMC Article | 06/21/2014 |
| A main role of SYD-2/Liprin-alpha in synaptogenesis is to regulate the polymerization of DPs. | Liprin-α/SYD-2 determines the size of dense projections in presynaptic active zones in C. elegans.
Kittelmann M, Hegermann J, Goncharov A, Taru H, Ellisman MH, Richmond JE, Jin Y, Eimer S., Free PMC Article | 03/8/2014 |
| tudy shows that SYD-2 promotes bi-directional mobility of DCVs and identifies SYD-2 as a novel regulator of DCV trafficking and polarized distribution | The scaffolding protein SYD-2/Liprin-α regulates the mobility and polarized distribution of dense-core vesicles in C. elegans motor neurons.
Goodwin PR, Juo P., Free PMC Article | 09/7/2013 |
| putative UNC-104 interactors, namely UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-alpha), inherit different functions in steering UNC-104 to specific sub-cellular locations in the neuron | Sub-cellular distribution of UNC-104(KIF1A) upon binding to adaptors as UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-α) in C. elegans neurons.
Hsu CC, Moncaleano JD, Wagner OI. | 06/4/2011 |
| we propose that the dense projection ensures proper coupling of primed vesicles with calcium signaling by retaining them at the active zone via UNC-10 and SYD-2 dependent mechanisms | The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions.
Stigloher C, Zhan H, Zhen M, Richmond J, Bessereau JL., Free PMC Article | 05/28/2011 |
| UNC-104 forms SYD-2-dependent axonal clusters (appearing during the transition from L2 to L3 larval stages), which behave in FRAP experiments as dynamic aggregates. | Synaptic scaffolding protein SYD-2 clusters and activates kinesin-3 UNC-104 in C. elegans.
Wagner OI, Esposito A, Köhler B, Chen CW, Shen CP, Wu GH, Butkevich E, Mandalapu S, Wenzel D, Wouters FS, Klopfenstein DR., Free PMC Article | 01/21/2010 |
| SYD-2, SYD-1 and UNC-10 were found essential for presynaptic site active zone assembly at synapses | The Yin and Yang of synaptic active zone assembly.
Sigrist SJ. | 01/21/2010 |
| Loss of function in C. elegans syd-2 Liprin-alpha alters the size of presynaptic specializations and disrupts synaptic vesicle accumulationA missense mutation in the coiled-coil domain of SYD-2 causes a gain of function. | SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.
Dai Y, Taru H, Deken SL, Grill B, Ackley B, Nonet ML, Jin Y. | 01/21/2010 |
| SYD-1 and SYD-2 function cell-autonomously at presynaptic terminals, downstream of synaptic specificity molecule SYG-1. SYD-1 is likely to act upstream of SYD-2 to positively regulate its synaptic assembly activity. | Hierarchical assembly of presynaptic components in defined C. elegans synapses.
Patel MR, Lehrman EK, Poon VY, Crump JG, Zhen M, Bargmann CI, Shen K., Free PMC Article | 01/21/2010 |