Dendritic morphological development of traumatic brain injury-induced new neurons in the dentate gyrus is important for post-injury cognitive recovery and is regulated by Notch1.
Weston NM, Green JC, Keoprasert TN, Sun D.,

Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis.
Mora P, Laisné M, Bourguignon C, Rouault P, Jaspard-Vinassa B, Maître M, Gadeau AP, Renault MA, Horng S, Couffinhal T, Chapouly C., Free PMC Article

Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis.
Liu M, Wang D, Qi C, Zou M, Song J, Li L, Xie H, Ren H, Hao H, Yang G, Li Z, Zhang Q, Zhou J, Ai D, Liu Q.

Notch transcriptional target tmtc1 maintains vascular homeostasis.
Paik NY, Neethling J, Anwar M, Gupta P, Sanborn MA, Shen Z, Bandara T, Hyun J, Naiche LA, Kitajewski JK, Rehman J, Shin JW, Mehta D, Pajcini KV., Free PMC Article

Rbm24/Notch1 signaling regulates adult neurogenesis in the subventricular zone and mediates Parkinson-associated olfactory dysfunction.
Wang K, Liu XY, Liu SF, Wang XX, Wei YH, Zhu JR, Liu J, Xu XQ, Wen L., Free PMC Article

Notch1 regulates hepatic thrombopoietin production.
Sun Y, Tong H, Chu X, Li Y, Zhang J, Ding Y, Zhang S, Gui X, Chen C, Xu M, Li Z, Gardiner EE, Andrews RK, Zeng L, Xu K, Qiao J.

Specific Knockout of Notch-1 in Macrophages Modulate the Progression of Hepatic Insulin Resistance in HFD Fed Mice via Regulating IRE1α-XBP1 Signals.
Zhou W, Ren S, Lu Y, Wang Y, Feng L, Gao Q.

Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse.
Kang JW, He JP, Liu YN, Zhang Y, Song SS, Xu QX, Wei SW, Lu L, Meng XQ, Xu L, Guo B, Su RW., Free PMC Article

Myeloid-specific knockout of Notch-1 inhibits MyD88- and TRIF-mediated TLR signaling pathways by regulating oxidative stress-SHP2 axis, thus restraining aneurysm progression.
Li Y, Guo A, Liu J, Tang L, Su L, Liu Z., Free PMC Article

miR-34a/TAN1/CREB Axis Engages in Alleviating Oligodendrocyte Trophic Factor-Induced Myelin Repair Function and Astrocyte-Dependent Neuroinflammation in the Early Stages of Alzheimer's Disease: The Anti-Neurodegenerative Effect of Treadmill Exercise.
Liu Y, Meng XK, Shao WZ, Liu YQ, Tang C, Deng SS, Tang CF, Zheng L, Guo W.

Hdac1 and Hdac2 positively regulate Notch1 gain-of-function pathogenic signaling in committed osteoblasts of male mice.
Torres HM, Hinojosa L, VanCleave AM, Rodezno T, Westendorf JJ, Tao J.,

Macrophage-specific deletion of Notch-1 induced M2 anti-inflammatory effect in atherosclerosis via activation of the PI3K-oxidative stress axis.
Zhang M, Yue X, Zhao X, Lu Y, Liu H, Zhang Z, Ma H, Wang X, Xing H., Free PMC Article

Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation.
Gao Q, Lu Y, Zhou W., Free PMC Article

Targeting Inhibition of Notch 1 Can Promote mTOR Signaling Pathway in Tumor-Related Macrophage to Regulate the Development of Ovarian Cancer.
Guo C, Mo J, Liu X, Chen Y, Liang L, Li H, Yang L.

Two NOTCH1 O-fucose sites have opposing functions in mouse retinal angiogenesis.
LoPilato RK, Kroeger H, Mohan SK, Lauderdale JD, Grimsey N, Haltiwanger RS., Free PMC Article

[Notch1 inhibits the mechanistic role of STING signaling to regulate hepatocyte lipophagy in nonalcoholic steatohepatitis].
Yang T, Zhao JY, Wang X, Fang ZG, Jiang LF, Li J.

Aberrant activation of Notch1 signaling in the mouse uterine epithelium promotes hyper-proliferation by increasing estrogen sensitivity.
Xu QX, Madhavan M, Wei SW, Zhang WQ, Lu L, Wang KZ, Genna M, Song Y, Zhao Y, Shao HT, Kang JW, Fazleabas AT, Arora R, Su RW., Free PMC Article

Ezrin accelerates breast cancer liver metastasis through promoting furin-like convertase-mediated cleavage of Notch1.
Chen M, Pan Y, Liu H, Ning F, Lu Q, Duan Y, Gan X, Lu S, Hou H, Zhang M, Tian Y, Lash GE.

Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties.
Sargis T, Youn SW, Thakkar K, Naiche LA, Paik NY, Pajcini KV, Kitajewski JK., Free PMC Article

KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress.
Issa N, Bjeije H, Wilson ER, Krishnan A, Dunuwille WMB, Parsons TM, Zhang CR, Han W, Young AL, Ren Z, Ge K, Wang ES, Weng AP, Cashen A, Spencer DH, Challen GA., Free PMC Article

HES1-mediated down-regulation of miR-138 sustains NOTCH1 activation and promotes proliferation and invasion in renal cell carcinoma.
Liu S, Dou L, Miao M, Man X, Wei B, Jiang Z, Ouyang Y, Ozaki T, Yu M, Zhu Y., Free PMC Article

Pregnenolone enhances the proliferation of mouse neural stem cells and promotes oligodendrogenesis, together with Sox10, and neurogenesis, along with Notch1 and Pax6.
Negintaji K, Ghanbari A, Frozanfar M, Jafarinia M, Zibara K.

Notch1 Is Involved in Physiologic Cardiac Hypertrophy of Mice via the p38 Signaling Pathway after Voluntary Running.
Zhang W, Liu J, Wu Z, Fan G, Yang Z, Liu C., Free PMC Article

Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.
Abby E, Dentro SC, Hall MWJ, Fowler JC, Ong SH, Sood R, Herms A, Piedrafita G, Abnizova I, Siebel CW, Gerstung M, Hall BA, Jones PH., Free PMC Article

A double-negative thymocyte-specific enhancer augments Notch1 signaling to direct early T cell progenitor expansion, lineage restriction and β-selection.
Kashiwagi M, Figueroa DS, Ay F, Morgan BA, Georgopoulos K., Free PMC Article