| Interaction between a J-domain co-chaperone and a specific Argonaute protein contributes to microRNA function in animals. | Interaction between a J-domain co-chaperone and a specific Argonaute protein contributes to microRNA function in animals.
Frédérick PM, Jannot G, Banville I, Simard MJ., Free PMC Article | 06/24/2024 |
| An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress. | An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress.
Vergani-Junior CA, Moro RP, Pinto S, De-Souza EA, Camara H, Braga DL, Tonon-da-Silva G, Knittel TL, Ruiz GP, Ludwig RG, Massirer KB, Mair WB, Mori MA., Free PMC Article | 04/24/2024 |
| The alg-1 Gene Is Necessary for Orsay Virus Replication in Caenorhabditis elegans. | The alg-1 Gene Is Necessary for Orsay Virus Replication in Caenorhabditis elegans.
Cubillas C, Sandoval Del Prado LE, Goldacker S, Fujii C, Pinski AN, Zielke J, Wang D., Free PMC Article | 05/17/2023 |
| The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans. | The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans.
Michaud P, Shah VN, Adjibade P, Houle F, Quévillon Huberdeau M, Rioux R, Lavoie-Ouellet C, Gu W, Mazroui R, Simard MJ., Free PMC Article | 08/28/2021 |
| Alg-1 regulates mRNA splicing pattern in muscle and intestine by modulating splicing factor activities. | ALG-1 Influences Accurate mRNA Splicing Patterns in the Caenorhabditis elegans Intestine and Body Muscle Tissues by Modulating Splicing Factor Activities.
Kotagama K, Schorr AL, Steber HS, Mangone M., Free PMC Article | 01/18/2020 |
| knockdown of alg-1 and alg-2 in germ cells results in few defects in oocyte maturation and ovulation. | Functional analysis of microRNA pathway genes in the somatic gonad and germ cells during ovulation in C. elegans.
Rios C, Warren D, Olson B, Abbott AL., Free PMC Article | 09/23/2017 |
| Pairing beyond the seed supports ALG-1 microRNA targeting specificity. | Pairing beyond the Seed Supports MicroRNA Targeting Specificity.
Broughton JP, Lovci MT, Huang JL, Yeo GW, Pasquinelli AE., Free PMC Article | 09/9/2017 |
| Altogether, these data suggest that the phosphorylation state of the serine/threonine cluster is important for Argonaute-mRNA interactions. | Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA-guided gene silencing in vivo.
Quévillon Huberdeau M, Zeitler DM, Hauptmann J, Bruckmann A, Fressigné L, Danner J, Piquet S, Strieder N, Engelmann JC, Jannot G, Deutzmann R, Simard MJ, Meister G., Free PMC Article | 07/29/2017 |
| We show in vitro and in vivo that their mutations severely altered the association with AIN-1 and AIN-2. our results demonstrate that the microRNA pathway can act independently of GW182 proteins during C. elegans embryogenesis | GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis.
Jannot G, Michaud P, Quévillon Huberdeau M, Morel-Berryman L, Brackbill JA, Piquet S, McJunkin K, Nakanishi K, Simard MJ., Free PMC Article | 05/13/2017 |
| ALG-1 complexes recognize structural features of particular microRNAs in the context of conducting the strand selection and microRNA* ejection steps of miRISC maturation | Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal.
Zinovyeva AY, Veksler-Lublinsky I, Vashisht AA, Wohlschlegel JA, Ambros VR., Free PMC Article | 01/2/2016 |
| The alg-1(anti) mutations broadly impair the function of many microRNAs. | Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression.
Zinovyeva AY, Bouasker S, Simard MJ, Hammell CM, Ambros V., Free PMC Article | 11/29/2014 |
| The slicing activity of ALG-1 is important to coordinate Dicer cleavage and thus is required for the formation of miRNA-induced silencing complex in C. elegans. | The slicing activity of miRNA-specific Argonautes is essential for the miRNA pathway in C. elegans.
Bouasker S, Simard MJ., Free PMC Article | 01/26/2013 |
| the Argonaute protein in Caenorhabditis elegans, ALG-1, binds to a specific site at the 3' end of let-7 miRNA primary transcripts and promotes downstream processing events | Autoregulation of microRNA biogenesis by let-7 and Argonaute.
Zisoulis DG, Kai ZS, Chang RK, Pasquinelli AE., Free PMC Article | 08/18/2012 |
| ALG-1 binds to cytoplasmic bodies and involved in developmental timing after regulatory protein AIN-1 interacts with miRISCs. | The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans.
Ding L, Spencer A, Morita K, Han M. | 01/21/2010 |
| genetic and biochemical data hint at individual nonredundant functions for ALG-1 and ALG-2 in the processing of precursor miRNAs to mature miRNAs | The Caenorhabditis elegans Argonautes ALG-1 and ALG-2: almost identical yet different.
Tops BB, Plasterk RH, Ketting RF. | 01/21/2010 |