| C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy. | C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy.
Zhang H, Li C, Liu Q, Li J, Wu H, Xu R, Sun Y, Cheng M, Zhao X, Pan M, Wei Q, Ma B., Free PMC Article | 10/30/2023 |
| Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice. | Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice.
Werner F, Prentki Santos E, Michel K, Schrader H, Völker K, Potapenko T, Krebes L, Abeßer M, Möllmann D, Schlattjan M, Schmidt H, Skryabin BV, Špiranec Spes K, Schuh K, Denton CP, Baba HA, Kuhn M., Free PMC Article | 07/12/2023 |
| The oocyte cumulus complex regulates mouse sperm migration in the oviduct. | The oocyte cumulus complex regulates mouse sperm migration in the oviduct.
Wang Z, Wei H, Wu Z, Zhang X, Sun Y, Gao L, Zhang W, Su YQ, Zhang M., Free PMC Article | 12/17/2022 |
| Effect of C-type natriuretic peptide on craniofacial skeletogenesis in mice during the pubertal growth spurt. | Effect of C-type natriuretic peptide on craniofacial skeletogenesis in mice during the pubertal growth spurt.
Kashiwagi M, Nakao K, Yamanaka S, Yamauchi I, Yamashita T, Fujii T, Ueda Y, Kawai MY, Watanabe T, Fukuhara S, Bessho K. | 05/28/2022 |
| C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis. | C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis.
Perez-Ternero C, Aubdool AA, Makwana R, Sanger GJ, Stimson RH, Chan LF, Moyes AJ, Hobbs AJ., Free PMC Article | 05/14/2022 |
| The mRNA-destabilizing protein Tristetraprolin targets ""meiosis arrester"" Nppc mRNA in mammalian preovulatory follicles. | The mRNA-destabilizing protein Tristetraprolin targets "meiosis arrester" Nppc mRNA in mammalian preovulatory follicles.
Xi G, An L, Wang W, Hao J, Yang Q, Ma L, Lu J, Wang Y, Wang W, Zhao W, Liu J, Yang M, Wang X, Zhang Z, Zhang C, Chu M, Yue Y, Yao F, Zhang M, Tian J., Free PMC Article | 12/4/2021 |
| CNP, via guanylyl cyclase-B/cyclic GMP signaling, stabilizes resident perivascular mast cells at baseline and prevents their excessive activation under pathological conditions. | Stabilization of Perivascular Mast Cells by Endothelial CNP (C-Type Natriuretic Peptide).
Chen W, Werner F, Illerhaus A, Knopp T, Völker K, Potapenko T, Hofmann U, Frantz S, Baba HA, Rösch M, Zernecke A, Karbach S, Wenzel P, Kuhn M. | 07/18/2020 |
| CNP is a critical regulator of preantral follicle growth, but also provides new insight in understanding the crosstalk between oocytes and somatic cells during early folliculogenesis. | C-type natriuretic peptide enhances mouse preantral follicle growth.
Xi G, Wang W, Fazlani SA, Yao F, Yang M, Hao J, An L, Tian J. | 05/2/2020 |
| in ovarian follicles, following the luteinizing hormone surge, NPPC levels increase initially and then decline rapidly | Impacts of macrophage colony-stimulating factor (M-CSF) on the expression of natriuretic peptide precursor type C (NPPC) and regulation of meiotic resumption.
Liu C, Sun W, Zhuo G, Zhang Z. | 09/28/2019 |
| In cultured interstitial aortic valve cells, CNP inhibited pathological differentiation via the guanylate cyclase NPR2 and not natriuretic peptide receptor 3. CNP/NPR2 signaling is a novel regulator of aortic valve development and disease. | Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice.
Blaser MC, Wei K, Adams RLE, Zhou YQ, Caruso LL, Mirzaei Z, Lam AY, Tam RKK, Zhang H, Heximer SP, Henkelman RM, Simmons CA. | 07/6/2019 |
| elevated in ovaries of polycystic ovary syndrome model | High level of C-type natriuretic peptide induced by hyperandrogen-mediated anovulation in polycystic ovary syndrome mice.
Wang X, Wang H, Liu W, Zhang Z, Zhang Y, Zhang W, Chen Z, Xia G, Wang C. | 07/6/2019 |
| the overexpression CNP in endothelial cells promoted BAT thermogenesis, leading to increased energy expenditure and decreased MesWAT adipocyte hypertrophy, fatty liver, insulin resistance, and inflammation in HFD-fed Tg mice. | Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity.
Bae CR, Hino J, Hosoda H, Arai Y, Son C, Makino H, Tokudome T, Tomita T, Kimura T, Nojiri T, Hosoda K, Miyazato M, Kangawa K., Free PMC Article | 04/20/2019 |
| the present study indicates that CNP and its cognate receptor NPR2 mainly expressed in neurons represent an innate neuroprotective mechanism in neonataI hypoxia-ischemia brain injury. | C-type natriuretic peptide functions as an innate neuroprotectant in neonatal hypoxic-ischemic brain injury in mouse via natriuretic peptide receptor 2.
Ma Q, Zhang L., Free PMC Article | 01/12/2019 |
| this study shows that Nppc induces sperm attraction for fertilization | Natriuretic peptide type C induces sperm attraction for fertilization in mouse.
Kong N, Xu X, Zhang Y, Wang Y, Hao X, Zhao Y, Qiao J, Xia G, Zhang M., Free PMC Article | 11/3/2018 |
| E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C and natriuretic peptide receptor 2 (NPPC/NPR2) | Estrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals.
Liu W, Xin Q, Wang X, Wang S, Wang H, Zhang W, Yang Y, Zhang Y, Zhang Z, Wang C, Xu Y, Duan E, Xia G., Free PMC Article | 11/4/2017 |
| The up-to-day world-wide data about the structure, distribution, and physiological effects of the most poorly known among the natriuretic peptides--the C-type (CNP)--are summarized in the review. | [C-TYPE NATRIURETIC PEP- TIDE: WHAT, WHERE AND WHAT FOR IS THIS?].
Korostyshevskaya IM, Maksimov VF, Rudenko NS. | 08/29/2015 |
| CNP activates bone turnover and remodeling in vivo and possibly accelerates fracture healing in a mouse model. | Increased Bone Turnover and Possible Accelerated Fracture Healing in a Murine Model With an Increased Circulating C-Type Natriuretic Peptide.
Kondo E, Yasoda A, Fujii T, Nakao K, Yamashita Y, Ueda-Sakane Y, Kanamoto N, Miura M, Arai H, Mukoyama M, Inagaki N, Nakao K. | 08/29/2015 |
| Connexin mimetics directed against connexin-43 (Cx43 CMP) overcame NPPC-mediated meiotic arrest in both isolated cumulus oocyte complexes and antral follicles. | Prophase I arrest of mouse oocytes mediated by natriuretic peptide precursor C requires GJA1 (connexin-43) and GJA4 (connexin-37) gap junctions in the antral follicle and cumulus-oocyte complex.
Richard S, Baltz JM. | 01/24/2015 |
| CNP/NPR-C pathway has potential as a disease-modifying therapeutic target for cardiovascular disorders | Endothelial C-type natriuretic peptide maintains vascular homeostasis.
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ, Rebstock AS, Worthington RJ, Simone MI, Mota F, Rivilla F, Vallejo S, Peiró C, Sánchez Ferrer CF, Djordjevic S, Caulfield MJ, MacAllister RJ, Selwood DL, Ahluwalia A, Hobbs AJ., Free PMC Article | 01/24/2015 |
| Data indicate an important, previously neglected, role of NEP for regulation of luminal factors in the epididymis and suggest a novel role for CNP/guanylyl cyclase B in the epididymal epithelium | Neutral endopeptidase (CD10) is abundantly expressed in the epididymis and localized to a distinct population of epithelial cells--its relevance for CNP degradation.
Thong A, Müller D, Feuerstacke C, Mietens A, Stammler A, Middendorff R. | 08/30/2014 |
| CNP overexpression in chondrocytes can prevent endochondral growth delay and protect against cartilage damage in a mouse model of inflammatory arthritis. | Protective effects of C-type natriuretic peptide on linear growth and articular cartilage integrity in a mouse model of inflammatory arthritis.
Bükülmez H, Khan F, Bartels CF, Murakami S, Ortiz-Lopez A, Sattar A, Haqqi TM, Warman ML., Free PMC Article | 03/22/2014 |
| Data suggest that intracerebroventricular administration of C-type natriuretic peptide (CNP-22 or CNP-53) has anorexigenic effect on hypothalamic neurons via activation of melanocortin/melanocortin receptor signal transduction. | Intracerebroventricular administration of C-type natriuretic peptide suppresses food intake via activation of the melanocortin system in mice.
Yamada-Goto N, Katsuura G, Ebihara K, Inuzuka M, Ochi Y, Yamashita Y, Kusakabe T, Yasoda A, Satoh-Asahara N, Ariyasu H, Hosoda K, Nakao K., Free PMC Article | 06/29/2013 |
| CNP/NPR2 signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin/EGFR signaling pathway suppresses this signal by downregulating Nppc expression. | CNP/NPR2 signaling maintains oocyte meiotic arrest in early antral follicles and is suppressed by EGFR-mediated signaling in preovulatory follicles.
Tsuji T, Kiyosu C, Akiyama K, Kunieda T. | 06/22/2013 |
| we show that CNP plays important region-specific roles in the GI tract of mice. | C-type natriuretic peptide specifically acts on the pylorus and large intestine in mouse gastrointestinal tract.
Sogawa C, Wakizaka H, Aung W, Jin ZH, Tsuji AB, Furukawa T, Kunieda T, Saga T. | 06/8/2013 |
| CNP secreted by growing follicles is capable of stimulating preantral and antral follicle growth | C-type natriuretic peptide stimulates ovarian follicle development.
Sato Y, Cheng Y, Kawamura K, Takae S, Hsueh AJ., Free PMC Article | 12/29/2012 |