| Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug users. | Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug users.
O'Higgins M, Benito A, Real-López M, Gil-Miravet I, Ochoa E, Haro G. | 02/22/2023 |
| Hypermethylation of DRD5 Promoter Is a Biomarker Across 12 Cancer Types. | Hypermethylation of DRD5 Promoter Is a Biomarker Across 12 Cancer Types.
Bai R, Mei J, Hu W. | 11/28/2020 |
| The effects of dopamine receptor genes on the trajectories of sport participation from adolescence through young adulthood. | The effects of dopamine receptor genes on the trajectories of sport participation from adolescence through young adulthood.
Lee CG, Moon H, Park S. | 11/21/2020 |
| These suggest that hD5R(F173L) increases blood pressure, in part, by decreasing renal thioredoxin 1 expression and increasing reactive oxygen species production. Hyperphosphorylation of hD5R(F173L), with its dissociation from Galphas and Galphaq, is the key factor in impaired D5R function of hD5R(F173L)-TG mice. | Role of Thioredoxin 1 in Impaired Renal Sodium Excretion of hD (5) R (F173L) Transgenic Mice.
Wang S, Tan X, Chen P, Zheng S, Ren H, Cai J, Zhou L, Jose PA, Yang J, Zeng C., Free PMC Article | 07/25/2020 |
| These results implicate DRD5 as a negative regulator of DRD2 signaling and tumor sensitivity to ONC201 DRD2 antagonism. | Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism.
Prabhu VV, Madhukar NS, Gilvary C, Kline CLB, Oster S, El-Deiry WS, Elemento O, Doherty F, VanEngelenburg A, Durrant J, Tarapore RS, Deacon S, Charter N, Jung J, Park DM, Gilbert MR, Rusert J, Wechsler-Reya R, Arrillaga-Romany I, Batchelor TT, Wen PY, Oster W, Allen JE., Free PMC Article | 05/16/2020 |
| Dopamine D5 receptor may play an important role in the preservation of normal heart function by inhibiting the production of reactive oxygen species, via inhibition of NADPH oxidase, Nrf2 degradation, and ERK1/2/JNK pathways. | Over-expression of a cardiac-specific human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROS over-generation by NADPH oxidase activation and Nrf2 degradation.
Jiang X, Liu Y, Liu X, Wang W, Wang Z, Hu Y, Zhang Y, Zhang Y, Jose PA, Wei Q, Yang Z., Free PMC Article | 12/22/2018 |
| The C allele of DRD5 rs6283 SNP was associated with decreased risk of awake bruxism (p = 0.01). | Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism.
Oporto GH 5th, Bornhardt T, Iturriaga V, Salazar LA. | 09/8/2018 |
| DRD5 (dopamine receptor D5) agonists were potent inhibitors of pituitary tumor growth. | Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death.
Leng ZG, Lin SJ, Wu ZR, Guo YH, Cai L, Shang HB, Tang H, Xue YJ, Lou MQ, Zhao W, Le WD, Zhao WG, Zhang X, Wu ZB., Free PMC Article | 05/12/2018 |
| Meta-analysis of data from six sites of the International Multicentre persistent ADHD CollaboraTion tested the association of the common DRD5 alleles with categorically defined ADHD and with inattentive and hyperactive/impulsive symptom counts, found evidence that none of the common DRD5 alleles are associated with ADHD risk or ADHD symptom counts in adults. | Meta-analysis of the DRD5 VNTR in persistent ADHD.
Klein M, Berger S, Hoogman M, Dammers J, Makkinje R, Heister AJGAM, Galesloot TE, Kiemeney LALM, Weber H, Kittel-Schneider S, Lesch KP, Reif A, Ribase S M, Ramos-Quiroga JA, Cormand B, Zayats T, Hegvik TA, Jacobsen KK, Johansson S, Haavik J, Mota NR, Bau CHD, Grevet EH, Doyle A, Faraone SV, Arias-Va Squez A, Franke B. | 01/20/2018 |
| Study investigated the contribution of DRD5 gene variants in the symptoms of attention-deficit/hyperactivity disorder (ADHD): 19 exonic variants were monomorphic in the Indo-Caucasoid individuals. rs6283 "C" and rs113828117 "A" exhibited significant higher occurrence in families with ADHD probands. Early and late onset groups exhibited significantly different genotypic frequencies. | The Dopamine Receptor D5 May Influence Age of Onset: An Exploratory Study on Indo-Caucasoid ADHD Subjects.
Maitra S, Sarkar K, Sinha S, Mukhopadhyay K. | 11/26/2017 |
| This study reveled that DRD5 are up regulation in CD4+ T effector and regulatory cells in patient with multiple sclerosis. | Dopaminergic receptors and adrenoceptors in circulating lymphocytes as putative biomarkers for the early onset and progression of multiple sclerosis.
Cosentino M, Zaffaroni M, Legnaro M, Bombelli R, Schembri L, Baroncini D, Bianchi A, Clerici R, Guidotti M, Banfi P, Bono G, Marino F. | 08/19/2017 |
| DRD5 gene expression reduction in breast cancer patients after spiritual intervention | The effects of spiritual intervention and changes in dopamine receptor gene expression in breast cancer patients.
Akbari ME, Kashani FL, Ahangari G, Pornour M, Hejazi H, Nooshinfar E, Kabiri M, Hosseini L. | 02/4/2017 |
| Conserved residues in intracellular loop 1 and transmembrane region 2 of DRD1 and DRD5 are essential in ligand binding and signal transduction. | Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: insights from ligand binding and signal transduction responses of D1 and D5 dopaminergic receptor mutants.
Zhang B, Yang X, Tiberi M. | 06/4/2016 |
| D1R and D5R colocalize in renal proximal tubule cells and physically interact in second messenger coupling pathways and heterologous receptor interaction between the two receptors. | The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport.
Gildea JJ, Shah IT, Van Sciver RE, Israel JA, Enzensperger C, McGrath HE, Jose PA, Felder RA., Free PMC Article | 05/7/2016 |
| This study shown DRD5 to be the risk factor for attention deficit/hyperactivity disorder. | Multiple epigenetic factors predict the attention deficit/hyperactivity disorder among the Chinese Han children.
Xu Y, Chen XT, Luo M, Tang Y, Zhang G, Wu D, Yang B, Ruan DY, Wang HL. | 01/16/2016 |
| LRs are essential not only for the proper membrane distribution and maintenance of AC5/6 activity but also for the regulation of D1R- and D5R-mediated AC signaling. | Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells.
Yu P, Sun M, Villar VA, Zhang Y, Weinman EJ, Felder RA, Jose PA., Free PMC Article | 05/16/2015 |
| This study demonistrated that Lymphocyte DR D5 is reduced in MS and IFN-beta restores their expression and responsiveness. | Levels of mRNA for dopaminergic receptor D₅ in circulating lymphocytes may be associated with subsequent response to interferon-β in patients with multiple sclerosis.
Cosentino M, Zaffaroni M, Marino F. | 02/21/2015 |
| We found significant negative correlations regarding the expression of the genes COMT, MAOB, DRD4, DRD5 and FOS, indicating that increased schizotypy coincides with higher levels of dopaminergic dysregulation on the mRNA-level. | Psychosis-proneness correlates with expression levels of dopaminergic genes.
Grant P, Gabriel F, Kuepper Y, Wielpuetz C, Hennig J. | 02/21/2015 |
| Constitutive D5R signalling up-regulated expression of Na,K-ATPase-alpha2 and NHE-2, increasing glucose metabolism. Agonist treatment increased this and also upregulated NHE-3. | Agonist-dependent and -independent dopamine-1-like receptor signalling differentially regulates downstream effectors.
Roosterman D. | 01/10/2015 |
| Our find-ings suggest that common genetic variations of DRD5 are likely to con-tribute to genetic susceptibility to paranoid schizophrenia in Han Chinese | Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese.
Zhao Y, Ding M, Pang H, Xu XM, Wang BJ. | 11/8/2014 |
| Its signaling regulates human osteoclastogenesis. (review) | [Dopamine receptor signaling regulates human osteoclastogenesis].
Hanami K, Nakano K, Tanaka Y. | 12/21/2013 |
| in this report, the specific amino acids in the cytoplasmic regions of D5 and D2 receptors involved in heteromer interactions were determined. | D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation.
O'Dowd BF, Nguyen T, Ji X, George SR., Free PMC Article | 08/31/2013 |
| confirmed at protein level the previously reported increased expression of DRD5 and the variably aberrant expression of ADORA2A, in Lesch-Nyhan disease lymphocytes | Adenosine, dopamine and serotonin receptors imbalance in lymphocytes of Lesch-Nyhan patients.
García MG, Puig JG, Torres RJ. | 04/6/2013 |
| SNX1 has a crucial role in D(5)R trafficking and SNX1 depletion results in D(5)R dysfunction and thus may represent a novel mechanism for the pathogenesis of essential hypertension | Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.
Villar VA, Jones JE, Armando I, Asico LD, Escano CS Jr, Lee H, Wang X, Yang Y, Pascua-Crusan AM, Palmes-Saloma CP, Felder RA, Jose PA., Free PMC Article | 03/2/2013 |
| Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells. | Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells.
Gildea JJ, Wang X, Shah N, Tran H, Spinosa M, Van Sciver R, Sasaki M, Yatabe J, Carey RM, Jose PA, Felder RA., Free PMC Article | 12/22/2012 |