| Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer. | Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.
Dietrich P, Wormser L, Fritz V, Seitz T, De Maria M, Schambony A, Kremer AE, Günther C, Itzel T, Thasler WE, Teufel A, Trebicka J, Hartmann A, Neurath MF, von Hörsten S, Bosserhoff AK, Hellerbrand C., Free PMC Article | 02/2/2021 |
| Study suggests that PYY3-36 mediated signalling via Y5 receptors may counteract the anorectic effects that it mediates via the Y2 receptor, consequently lowering bodyweight in the absence of Y5 signalling. | Y5 receptor signalling counteracts the anorectic effects of PYY3-36 in diet-induced obese mice.
Shi YC, Ip CK, Reed F, Sarruf DA, Wulff BS, Herzog H. | 06/9/2018 |
| NPY and agonists of Y2R and Y5R may be neuroprotective against oxygen-glucose deprivation-induced neuronal cell death in primary cortical cell cultures after delayed treatment. A Y2R agonist not only diminished transient cerebral ischemia-induced neuronal injury, but also improved functional outcome after delayed treatment. Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage | Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats.
Domin H, Przykaza Ł, Jantas D, Kozniewska E, Boguszewski PM, Śmiałowska M. | 11/11/2017 |
| Y5-immunoreactivity was distributed widely in mouse brain, and the Y5 protein localization was mostly observed in the somata of the Y5 neurons. By purifying the polyclonal antibody with fixed knockout mouse tissue, the precise Y5 localization became obvious in mouse brain, especially in areas other than the hypothalamic area. | Neuropeptide Y Y(5) receptor localization in mouse central nervous system.
Murase SI, Shiiya T, Higuchi H. | 08/12/2017 |
| Npy1r(Y5R-/-) mice show increased anxiety-related behavior but no changes in hypothalamus-pituitary-adrenocortical axis activity or in body weight growth, independently of gender and mouse strain used as foster mothers. Also, Npy1r(Y5R-/-) mice of both genders display increased spatial reference memory in the Morris water maze test. | Conditional inactivation of neuropeptide Y Y1 receptors unravels the role of Y1 and Y5 receptors coexpressing neurons in anxiety.
Longo A, Mele P, Bertocchi I, Oberto A, Bachmann A, Bartolomucci A, Palanza P, Sprengel R, Eva C. | 07/25/2015 |
| Study shows pronounced adaptive changes in the mouse hippocampus both with regard to NPY synthesis and NPY receptor synthesis and binding, which may contribute to regulating neuronal seizure susceptibility after kainate | Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the hippocampus after kainate-induced seizures in mice.
Elbrønd-Bek H, Olling JD, Gøtzsche CR, Waterfield A, Wörtwein G, Woldbye DP. | 05/16/2015 |
| Y5 KO mice display increased grooming and rearing in the open field, lower ratio entries in open arms in the elevated plus maze and increased immobility time on the second day of the forced swim test | Mood and memory-associated behaviors in neuropeptide Y5 knockout mice.
Ito M, Dumont Y, Quirion R. | 08/31/2013 |
| data indicate that Y5 antagonism may attenuate cocaine-induced behavioural effects. | Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.
Sørensen G, Jensen M, Weikop P, Dencker D, Christiansen SH, Loland CJ, Bengtsen CH, Petersen JH, Fink-Jensen A, Wörtwein G, Woldbye DP. | 01/26/2013 |
| These studies demonstrate the pivotal, combined role of both Y1 and Y5 receptors in the mediation of food intake. | Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice.
Nguyen AD, Mitchell NF, Lin S, Macia L, Yulyaningsih E, Baldock PA, Enriquez RF, Zhang L, Shi YC, Zolotukhin S, Herzog H, Sainsbury A., Free PMC Article | 12/8/2012 |
| These results do not support a potential role for single transgene overexpression of Y5 receptors for modulating anxiety-/depression-like behaviours or seizures in adult mice. | Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity.
Olesen MV, Christiansen SH, Gøtzsche CR, Holst B, Kokaia M, Woldbye DP. | 07/21/2012 |
| These findings confirm an interaction between neuropeptide Y(1) and Y(5) receptors in the regulation of energy homeostasis. | Synergistic interaction between neuropeptide Y1 and Y5 receptor pathways in regulation of energy homeostasis.
Mashiko S, Moriya R, Ishihara A, Gomori A, Matsushita H, Egashira S, Iwaasa H, Takahashi T, Haga Y, Fukami T, Kanatani A. | 01/21/2010 |
| Feeding behavior and gene expression of appetite-related neuropeptides in mice lacking for neuropeptide Y Y5 receptor subclass. | Feeding behavior and gene expression of appetite-related neuropeptides in mice lacking for neuropeptide Y Y5 receptor subclass.
Higuchi H, Niki T, Shiiya T., Free PMC Article | 01/21/2010 |
| Show that spironolactone Y5 receptor antagonist has potent antiobesity effects in obese mice. | Effects of a novel Y5 antagonist in obese mice: combination with food restriction or sibutramine.
Mashiko S, Ishihara A, Iwaasa H, Moriya R, Kitazawa H, Mitobe Y, Ito J, Gomori A, Matsushita H, Takahashi T, MacNeil DJ, Van der Ploeg LH, Fukami T, Kanatani A. | 01/21/2010 |
| these data provide a detailed and comparative mapping of Y(1) and Y(5) receptor promoter activity within cells of the mouse brain | Expression patterns of promoters for NPY Y(1) and Y(5) receptors in Y(5)RitTA and Y(1)RVenus BAC-transgenic mice.
Oberto A, Acquadro E, Bus T, Sprengel R, Eva C. | 01/21/2010 |
| Npy5r antagonist-treated mice showed an up-regulation of uncoupling protein mRNA in brown adipose tissue (BAT) and white adipose tissue (WAT), suggesting that both BAT and WAT contribute to energy expenditure. | A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.
Mashiko S, Ishihara A, Iwaasa H, Sano H, Ito J, Gomori A, Oda Z, Moriya R, Matsushita H, Jitsuoka M, Okamoto O, MacNeil DJ, Van der Ploeg LH, Fukami T, Kanatani A. | 01/21/2010 |
| The Y5 receptor subtype, previously believed to mediate food intake, plays a critical role in modulation of hippocampal excitatory transmission at the hilar-to-CA3 synapse in the mouse | Y5 receptors mediate neuropeptide Y actions at excitatory synapses in area CA3 of the mouse hippocampus.
Guo H, Castro PA, Palmiter RD, Baraban SC. | 01/21/2010 |
| biological redundancies between Y1 and Y5 receptor signaling in the NPY-mediated control of food intake. | Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression.
Raposinho PD, Pedrazzini T, White RB, Palmiter RD, Aubert ML. | 01/21/2010 |
| A limited distribution of Y5R expression is found in the hypothalamus; this receptor may be involved primarily in feeding and body weight control via neuropeptide Y's action on proopiomelanocortin-expressing neurons. | Characterization of neuropeptide Y Y2 and Y5 receptor expression in the mouse hypothalamus.
Fetissov SO, Byrne LC, Hassani H, Ernfors P, Hökfelt T. | 01/21/2010 |
| Results indicate that the NPY Y5 receptor Y5R is involved in the regulation and development of diet-induced obesity and suggest utility for Y5R antagonists in the treatment of obesity. | A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice.
Ishihara A, Kanatani A, Mashiko S, Tanaka T, Hidaka M, Gomori A, Iwaasa H, Murai N, Egashira S, Murai T, Mitobe Y, Matsushita H, Okamoto O, Sato N, Jitsuoka M, Fukuroda T, Ohe T, Guan X, MacNeil DJ, Van der Ploeg LH, Nishikibe M, Ishii Y, Ihara M, Fukami T., Free PMC Article | 01/21/2010 |
| Taken together, these data suggest that, in mice, both Y2 and Y5 receptors regulate hippocampal seizures in vitro, while activation of Y5 receptors in extra-hippocampal regions reduces generalized seizures in vivo. | Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors.
Woldbye DP, Nanobashvili A, Sørensen AT, Husum H, Bolwig TG, Sørensen G, Ernfors P, Kokaia M. | 01/21/2010 |