| Stable expression and multi-site location of Odf2 in mouse oocytes, sperm and early embryos. | Stable expression and multi-site location of Odf2 in mouse oocytes, sperm and early embryos.
Xu X, Jiang X, Song K, Zhang J, Tian Y, Chen Y, Weng J, Liang Y, Ma W. | 10/28/2023 |
| [Impacts of ODF2 gene knockdown on the sperm motility and fertility of male mice]. | [Impacts of ODF2 gene knockdown on the sperm motility and fertility of male mice].
Lü ZL, Shan XD, DU J, Zhu SM, Zhuang J, Liang X, Zhao QM. | 10/25/2023 |
| BBOF1 is required for sperm motility and male fertility by stabilizing the flagellar axoneme in mice. | BBOF1 is required for sperm motility and male fertility by stabilizing the flagellar axoneme in mice.
Cao H, Xu H, Zhou Y, Xu W, Lu Q, Jiang L, Rong Y, Zhang Q, Yu C., Free PMC Article | 06/7/2023 |
| C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length. | C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length.
Nayak SC, Radha V. | 07/31/2021 |
| Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice. | Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice.
Ito C, Akutsu H, Yao R, Yoshida K, Yamatoya K, Mutoh T, Makino T, Aoyama K, Ishikawa H, Kunimoto K, Tsukita S, Noda T, Kikkawa M, Toshimori K, Ito C, Akutsu H, Yao R, Yoshida K, Yamatoya K, Mutoh T, Makino T, Aoyama K, Ishikawa H, Kunimoto K, Tsukita S, Noda T, Kikkawa M, Toshimori K., Free PMC Articles: PMC6776547, PMC6776547 | 11/21/2020 |
| Odf2-deficiency causes sperm neck-midpiece separation, a new type of decapitated and decaudated spermatozoa (DDS), Odf2-DDS, whose semen contains abnormal spermatozoa with immotile tailless headnecks and motile headneckless tails. | Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice.
Ito C, Akutsu H, Yao R, Yoshida K, Yamatoya K, Mutoh T, Makino T, Aoyama K, Ishikawa H, Kunimoto K, Tsukita S, Noda T, Kikkawa M, Toshimori K, Ito C, Akutsu H, Yao R, Yoshida K, Yamatoya K, Mutoh T, Makino T, Aoyama K, Ishikawa H, Kunimoto K, Tsukita S, Noda T, Kikkawa M, Toshimori K., Free PMC Articles: PMC6776547, PMC6776547 | 01/3/2020 |
| Data show that the percentage of outer dense fiber of sperm tails 2 protein (ODF2) defects was higher in asthenozoospermic samples than that in control samples and was significantly correlated with the percentage of axoneme defects and non-motile sperm. | Outer dense fibers stabilize the axoneme to maintain sperm motility.
Zhao W, Li Z, Ping P, Wang G, Yuan X, Sun F., Free PMC Article | 10/26/2019 |
| The authors developed an Mrkn2 knockout mouse model to study the role of this gene, and found that deletion of Mkrn2 in mice led to male infertility and expression of Odf2, a vital protein in spermatogenesis, was significantly decreased. | Deficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility.
Qian X, Wang L, Zheng B, Shi ZM, Ge X, Jiang CF, Qian YC, Li DM, Li W, Liu X, Yin Y, Zheng JT, Shen H, Wang M, Guo XJ, He J, Lin M, Liu LZ, Sha JH, Jiang BH., Free PMC Article | 06/23/2018 |
| the C-terminal region (amino acids 214-638) of Odf2 is required for association with Tssk4; demonstrated the phosphorylation site in Odf2 by Tssk4 | Testis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76.
Wang X, Li H, Fu G, Wang Y, Du S, Yu L, Wei Y, Chen S., Free PMC Article | 07/22/2017 |
| Pax6 directly regulates the activity of the Odf2 gene encoding for the appendage-specific protein Odf2 with a role for the assembly of mother centriole. | Pax6 controls centriole maturation in cortical progenitors through Odf2.
Tylkowski MA, Yang K, Hoyer-Fender S, Stoykova A., Free PMC Article | 06/27/2015 |
| The presence of multiple splicing variants hints that the function of Odf2 is diversified in such a way that each variant has a distinct role in the complex cellular and developmental processes. | Essential role of Cenexin1, but not Odf2, in ciliogenesis.
Chang J, Seo SG, Lee KH, Nagashima K, Bang JK, Kim BY, Erikson RL, Lee KW, Lee HJ, Park JE, Lee KS., Free PMC Article | 07/27/2013 |
| In adult mice, Odf2 expression was marked in the interdental cells, Boettcher cells, the root cells and root cell processes. Fainter expression was also visible in the hair cells of the maculae and cristae | Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti.
Carlisle FA, Steel KP, Lewis MA., Free PMC Article | 08/18/2012 |
| C-terminal region of Odf2 in mice is sufficient for ciliogenesis, the resulting basal bodies lack basal feet; loss of basal feet in ciliated epithelia disrupts polarized organization of apical microtubule lattice without affecting planar cell polarity. | Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet.
Kunimoto K, Yamazaki Y, Nishida T, Shinohara K, Ishikawa H, Hasegawa T, Okanoue T, Hamada H, Noda T, Tamura A, Tsukita S, Tsukita S. | 03/17/2012 |
| Results document the possible impact of loss of one Odf2 allele on sperm tail structure and function, resulting in a novel sperm tail phenotype. | Gene trap mutation of murine outer dense fiber protein-2 gene can result in sperm tail abnormalities in mice with high percentage chimaerism.
Tarnasky H, Cheng M, Ou Y, Thundathil JC, Oko R, van der Hoorn FA., Free PMC Article | 08/16/2010 |
| Odf2 contributes to assorted ciliopathies | Mouse Odf2 localizes to centrosomes and basal bodies in adult tissues and to the photoreceptor primary cilium.
Schweizer S, Hoyer-Fender S., Free PMC Article | 08/2/2010 |
| findings show that testicular expression of Odf2 correlates with spermiogenesis and ongoing sperm tail formation thus implicating functional differences between ODF2 and Cenexin. | Molecular dissection of ODF2/Cenexin revealed a short stretch of amino acids necessary for targeting to the centrosome and the primary cilium.
Hüber D, Geisler S, Monecke S, Hoyer-Fender S. | 01/21/2010 |
| ODF2 is the main isoform in testicular tissue RT-PCR analyses revealed that isoforms are not restricted to specific tissues | Alternative splicing of exon 3b gives rise to ODF2 and Cenexin.
Hüber D, Hoyer-Fender S. | 01/21/2010 |
| Odf2 is indispensable for the formation of distal/subdistal appendages and the generation of primary cilia, but not for other cell-cycle-related centriolar functions. | Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia.
Ishikawa H, Kubo A, Tsukita S, Tsukita S. | 01/21/2010 |
| Knockout of the abundant sperm tail protein, outer dense fiber 2, results in preimplantation lethality. | A gene trap knockout of the abundant sperm tail protein, outer dense fiber 2, results in preimplantation lethality.
Salmon NA, Reijo Pera RA, Xu EY., Free PMC Article | 01/21/2010 |