| Mutant TP53 promotes invasion of lung cancer cells by regulating desmoglein 3. | Mutant TP53 promotes invasion of lung cancer cells by regulating desmoglein 3.
Feng Y, Qian R, Cui D, Luan J, Xu M, Wang L, Li R, Wu X, Chang C., Free PMC Article | 07/9/2024 |
| Type 2 T-Cell Responses against Distinct Epitopes of the Desmoglein 3 Ectodomain in Pemphigus Vulgaris. | Type 2 T-Cell Responses against Distinct Epitopes of the Desmoglein 3 Ectodomain in Pemphigus Vulgaris.
Didona D, Scarsella L, Hudemann C, Volkmann K, Zimmer CL, Beckert B, Tikkanen R, Korff V, Kühn K, Wienzek-Lischka S, Bein G, Di Zenzo G, Böhme J, Cunha T, Solimani F, Pieper J, Juratli HA, Göbel M, Schmidt T, Borradori L, Yazdi AS, Sitaru C, Garn H, Eming R, Fleischer S, Hertl M. | 01/27/2024 |
| Homozygous deletion of the DSG3 terminal exon associated with acantholytic blistering of the oral and laryngeal mucosa. | Homozygous deletion of the DSG3 terminal exon associated with acantholytic blistering of the oral and laryngeal mucosa.
Jiang N, Sewell TB, Kowalski TL, Rekab A, Hills S, Fazlollahi L, Lauren CT, Morel K, Mehta L, Liao J. | 01/12/2024 |
| Interleukin-37 inhibits desmoglein-3 endocytosis and keratinocyte dissociation via upregulation of Caveolin-1 and inhibition of the STAT3 pathway. | Interleukin-37 inhibits desmoglein-3 endocytosis and keratinocyte dissociation via upregulation of Caveolin-1 and inhibition of the STAT3 pathway.
Liang J, Hu F, Mao L, Qiu Y, Jiang F, Wang Q, Abulikemu K, Hong Y, Ge X, Kang X. | 09/6/2023 |
| Cytoskeletal anchorage of different Dsg3 pools revealed by combination of hybrid STED/SMFS-AFM. | Cytoskeletal anchorage of different Dsg3 pools revealed by combination of hybrid STED/SMFS-AFM.
Fuchs M, Radeva MY, Spindler V, Vielmuth F, Kugelmann D, Waschke J., Free PMC Article | 01/14/2023 |
| Desmoglein 3 (Dsg3) expression in cancer: A tissue microarray study on 15,869 tumors. | Desmoglein 3 (Dsg3) expression in cancer: A tissue microarray study on 15,869 tumors.
Viehweger F, Azem A, Gorbokon N, Uhlig R, Lennartz M, Dwertmann Rico S, Kind S, Reiswich V, Kluth M, Hube-Magg C, Bernreuther C, Büscheck F, Clauditz TS, Fraune C, Jacobsen F, Krech T, Lebok P, Steurer S, Burandt E, Minner S, Marx AH, Simon R, Sauter G, Menz A, Hinsch A. | 12/17/2022 |
| Dsg1 and Dsg3 Composition of Desmosomes Across Human Epidermis and Alterations in Pemphigus Vulgaris Patient Skin. | Dsg1 and Dsg3 Composition of Desmosomes Across Human Epidermis and Alterations in Pemphigus Vulgaris Patient Skin.
Schmitt T, Pircher J, Steinert L, Meier K, Ghoreschi K, Vielmuth F, Kugelmann D, Waschke J., Free PMC Article | 06/25/2022 |
| Desmoglein-3 induces YAP phosphorylation and inactivation during collective migration of oral carcinoma cells. | Desmoglein-3 induces YAP phosphorylation and inactivation during collective migration of oral carcinoma cells.
Ahmad US, Parkinson EK, Wan H., Free PMC Article | 05/7/2022 |
| Up-regulation of ST18 in pemphigus vulgaris drives a self-amplifying p53-dependent pathomechanism resulting in decreased desmoglein 3 expression. | Up-regulation of ST18 in pemphigus vulgaris drives a self-amplifying p53-dependent pathomechanism resulting in decreased desmoglein 3 expression.
Assaf S, Vodo D, Malovitski K, Mohamad J, Bergson S, Feller Y, Malki L, Sarig O, Sprecher E., Free PMC Article | 04/23/2022 |
| Analysis of the Specificity of Auto-Reactive Antibodies to Individual Fragments of the Extracellular Domain of Desmoglein 3 in Patients with Pemphigus Vulgaris. | Analysis of the Specificity of Auto-Reactive Antibodies to Individual Fragments of the Extracellular Domain of Desmoglein 3 in Patients with Pemphigus Vulgaris.
Kubanov AA, Deryabin DG, Shpilevaya MV, Karamova AE, Nikonorov AA, Larina EN, Aliev TK, Dolgikh DA, Bobik TV, Smirnov IV, Gabibov AG, Kirpichnikov MP. | 02/5/2022 |
| A potential link between desmoglein 3 and epidermal growth factor receptor in oral squamous cell carcinoma and its effect on cetuximab treatment efficacy. | A potential link between desmoglein 3 and epidermal growth factor receptor in oral squamous cell carcinoma and its effect on cetuximab treatment efficacy.
Minabe M, Akiyama Y, Higa K, Tachikawa T, Takahashi S, Nomura T, Kouno M. | 10/3/2020 |
| The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53. | The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53.
Rehman A, Cai Y, Hünefeld C, Jedličková H, Huang Y, Teck Teh M, Sharif Ahmad U, Uttagomol J, Wang Y, Kang A, Warnes G, Harwood C, Bergamaschi D, Kenneth Parkinson E, Röcken M, Wan H., Free PMC Article | 08/22/2020 |
| Report have provided evidence that Dsg3 seems to act as a regulator of YAP and phospho-YAP (pYAP) in cell proliferation and in response to mechanical stress via at least one mechanism of forming a complex with pYAP and regulating its cellular localization. | Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces.
Uttagomol J, Ahmad US, Rehman A, Huang Y, Laly AC, Kang A, Soetaert J, Chance R, Teh MT, Connelly JT, Wan H., Free PMC Article | 05/2/2020 |
| Study shows a precise time course of DSG3 endocytosis and keratin retraction in response to pemphigus vulgaris (PV)-IgG, dissecting the temporal relationship of two hallmarks of PV. Results demonstrate that both mechanisms contribute to loss of cell cohesion but appear to be largely independent of each other. | Keratin Retraction and Desmoglein3 Internalization Independently Contribute to Autoantibody-Induced Cell Dissociation in Pemphigus Vulgaris.
Schlögl E, Radeva MY, Vielmuth F, Schinner C, Waschke J, Spindler V., Free PMC Article | 07/27/2019 |
| These results demonstrate that signaling patterns parallel the clinical phenotype of pemphigus as some mechanisms involved in loss of cell cohesion are caused by antibodies targeting Dsg3 whereas others correlate with autoantibodies against Dsg1. | Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus.
Walter E, Vielmuth F, Rotkopf L, Sárdy M, Horváth ON, Goebeler M, Schmidt E, Eming R, Hertl M, Spindler V, Waschke J., Free PMC Article | 06/8/2019 |
| flotillin has a role in desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes | Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes.
Völlner F, Ali J, Kurrle N, Exner Y, Eming R, Hertl M, Banning A, Tikkanen R., Free PMC Article | 05/19/2018 |
| our findings suggest that Dsg3 functions as a key in cell-cell adhesion through at least a mechanism of regulating E-cadherin membrane trafficking | Desmoglein 3 regulates membrane trafficking of cadherins, an implication in cell-cell adhesion.
Moftah H, Dias K, Apu EH, Liu L, Uttagomol J, Bergmeier L, Kermorgant S, Wan H., Free PMC Article | 03/17/2018 |
| Desmoglein 3 Order and Dynamics in Desmosomes | Desmoglein 3 Order and Dynamics in Desmosomes Determined by Fluorescence Polarization Microscopy.
Bartle EI, Urner TM, Raju SS, Mattheyses AL., Free PMC Article | 01/6/2018 |
| Data indicate that all 3 monoclonal antibodies (mAbs) targeted the same extracellular cadherin (EC) domain on desmoglein 3 (Dsg3), caused Dsg3 internalization in primary keratinocytes, and caused suprabasal blisters in skin. | Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies in Pemphigus Vulgaris.
Lo AS, Mao X, Mukherjee EM, Ellebrecht CT, Yu X, Posner MR, Payne AS, Cavacini LA., Free PMC Article | 07/22/2017 |
| DSG3 was a key prognostic factor and predictor for neoadjuvant concurrent chemoradiotherapy response in rectal cancer patients. | Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy.
Chao TB, Li CF, Lin CY, Tian YF, Chang IW, Sheu MJ, Lee YE, Chan TC, He HL. | 03/11/2017 |
| Treg cells exert a clear down-regulatory effect on the Dsg3-driven T-cell response and, accordingly, the formation of Dsg3-specific IgG antibodies | Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris.
Schmidt T, Willenborg S, Hünig T, Deeg CA, Sonderstrup G, Hertl M, Eming R. | 02/18/2017 |
| Data identify DSG3 as a negative prognostic biomarker in resected pancreatic ductal adenocarcinoma, as high DSG3 expression is associated with poor overall survival and poor tumour-specific survival. | Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma.
Ormanns S, Altendorf-Hofmann A, Jackstadt R, Horst D, Assmann G, Zhao Y, Bruns C, Kirchner T, Knösel T., Free PMC Article | 03/5/2016 |
| this study directly demonstrates the occurrence of desmoglein 3 molecules outside of desmosomes and reveales that the adhesive properties of these molecules do differ depending on their localization. | Atomic force microscopy identifies regions of distinct desmoglein 3 adhesive properties on living keratinocytes.
Vielmuth F, Hartlieb E, Kugelmann D, Waschke J, Spindler V. | 12/26/2015 |
| DSG2 and DSG3 might be potential diagnostic markers for squamous cell carcinoma of the lung and DSG3 could be a potential differentiation marker for lung cancer. | Expression of desmogleins 1-3 and their clinical impacts on human lung cancer.
Saaber F, Chen Y, Cui T, Yang L, Mireskandari M, Petersen I. | 12/12/2015 |
| alterations of their expression suggest a role of Dsg3 and gamma-catenin (additionally to E-cadherin/beta-catenin) as biomarkers of malignant transformation risk of oral dysplasia and the biological behavior (aggressiveness) of oral cancer, respectively | Desmoglein-3/γ-catenin and E-cadherin/ß-catenin differential expression in oral leukoplakia and squamous cell carcinoma.
Kyrodimou M, Andreadis D, Drougou A, Amanatiadou EP, Angelis L, Barbatis C, Epivatianos A, Vizirianakis IS. | 10/10/2015 |