| Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer. | Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer.
Ren D, Li W, Zeng R, Liu X, Liang H, Xiong W, Yang C, Jin X., | 07/16/2024 |
| Down-regulation of DUSP2 expression in serous ovarian carcinoma was an independent risk factor for patient survival. | Expression of Dual-Specificity Phosphatase 2 (DUSP2) in Patients with Serous Ovarian Carcinoma and in SKOV3 and OVCAR3 Cells In Vitro.
Liu W, Tian X, Ding X, Zhang L., Free PMC Article | 05/30/2020 |
| PAC1 is selectively upregulated in exhausted tumor-infiltrating lymphocytes and is associated with poor prognosis of patients with cancer. PAC1(hi) effector T cells lose their proliferative and effector capacities and convert into exhausted T cells. | The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity.
Dan Lu, Liu L, Sun Y, Song J, Yin Q, Zhang G, Qi F, Hu Z, Yang Z, Zhou Z, Hu Y, Zhang L, Ji J, Zhao X, Jin Y, McNutt MA, Yin Y. | 04/25/2020 |
| Taken together, our findings for the first time suggested DUSP2 as a progression and prognosis biomarker for bladder cancer. | Loss of DUSP2 predicts a poor prognosis in patients with bladder cancer.
Yin H, He W, Li Y, Xu N, Zhu X, Lin Y, Gou X. | 11/30/2019 |
| Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2 has been reported. | Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2.
Perander M, Al-Mahdi R, Jensen TC, Nunn JA, Kildalsen H, Johansen B, Gabrielsen M, Keyse SM, Seternes OM., Free PMC Article | 11/17/2018 |
| hypoxia-induced IL-6 production in endometriotic lesions is mediated via downregulation of DUSP2, which causes aberrant activation of STAT3 signaling pathway and helps the endometriotic cells survive under the ectopic environment | Hypoxia-inhibited DUSP2 expression promotes IL-6/STAT3 signaling in endometriosis.
Hsiao KY, Chang N, Tsai JL, Lin SC, Tsai SJ, Wu MH. | 05/26/2018 |
| Authors report that hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for the accumulation of CSC in colorectal cancer. | Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness.
Hou PC, Li YH, Lin SC, Lin SC, Lee JC, Lin BW, Liou JP, Chang JY, Kuo CC, Liu YM, Sun HS, Tsai SJ. | 09/30/2017 |
| Hypoxia inhibits DUSP2 expression in colon cancer, leading to up-regulation of IL-8, which facilitates angiogenesis and tumour metastasis. | Loss of dual-specificity phosphatase-2 promotes angiogenesis and metastasis via up-regulation of interleukin-8 in colon cancer.
Lin SC, Hsiao KY, Chang N, Hou PC, Tsai SJ. | 09/2/2017 |
| Our data show that aberrant epigenetic inactivation of DUSP2 occurs in carcinogenesis and that CTCF is involved in the epigenetic regulation of DUSP2 expression. | The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms.
Haag T, Richter AM, Schneider MB, Jiménez AP, Dammann RH., Free PMC Article | 10/8/2016 |
| Highly recurrent mutation of DUSP2 is associated with nodular lymphocyte predominant Hodgkin lymphoma. | Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma.
Hartmann S, Schuhmacher B, Rausch T, Fuller L, Döring C, Weniger M, Lollies A, Weiser C, Thurner L, Rengstl B, Brunnberg U, Vornanen M, Pfreundschuh M, Benes V, Küppers R, Newrzela S, Hansmann ML. | 09/17/2016 |
| identified among the key genes in circulating monocytes that were altered by exercise | Brief Exercises Affect Gene Expression in Circulating Monocytes.
Wang D, Cai F, Ge J, Yin L. | 01/30/2016 |
| Data show that hypoxia promotes lapatinib resistance in ERBB2-positive breast cancer cells through activation of the MEK-ERK pathway a HIF-1-dependent manner via regulation of dual-specificity phosphatase 2 (DUSP2). | Hypoxia/HIF1α induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2.
Karakashev SV, Reginato MJ., Free PMC Article | 12/5/2015 |
| DUSP2 is an important molecule in endometrial physiology and that hypoxia-inhibited DUSP2 expression is a critical factor for the development of endometriosis. | Hypoxia-inhibited dual-specificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression.
Wu MH, Lin SC, Hsiao KY, Tsai SJ. | 12/3/2011 |
| Dipyridamole reduced expression of PAC-1 and CD62p in patients with malignant lymphoma. | [Influence of dipyridamole on expression of PAC-1 and CD62p in patients with malignant lymphoma].
Jiang YJ, Li XM, Wang HX, Kang LL, Zhu GH, Zhuang WC. | 10/1/2011 |
| DUSP2 is a key downstream regulator of HIF-1-mediated tumor progression and chemoresistance | Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells.
Lin SC, Chien CW, Lee JC, Yeh YC, Hsu KF, Lai YY, Lin SC, Tsai SJ., Free PMC Article | 07/16/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Induction of hypercortisolism in healthy volunteers was not associated with changes in the platelet activation marker PAC-1 or the number of circulating platelet-leucocyte aggregates. | How depression may increase cardiac risk: effect of hypercortisolism on platelet activation markers: preliminary data.
Baranyai R, Nonell A, Deuschle M, Lederbogen F. | 01/21/2010 |
| a novel, stimulus-specific, and phosphatase-specific mechanism of ERK2 regulation in the nucleus by DUSP1, -2, and -4. | Epidermal growth factor receptor and protein kinase C signaling to ERK2: spatiotemporal regulation of ERK2 by dual specificity phosphatases.
Caunt CJ, Rivers CA, Conway-Campbell BL, Norman MR, McArdle CA., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma.
Cerhan JR, Ansell SM, Fredericksen ZS, Kay NE, Liebow M, Call TG, Dogan A, Cunningham JM, Wang AH, Liu-Mares W, Macon WR, Jelinek D, Witzig TE, Habermann TM, Slager SL. | 03/13/2008 |
| These results reveal a crucial role of PAC1 in E2F-1-directed apoptosis. | PAC1 is a direct transcription target of E2F-1 in apoptotic signaling.
Wu J, Jin YJ, Calaf GM, Huang WL, Yin Y. | 01/21/2010 |
| During apoptosis, p53 activates transcription of PAC1 by binding to a palindromic site in the PAC1 promoter | PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression.
Yin Y, Liu YX, Jin YJ, Hall EJ, Barrett JC. | 01/21/2010 |
| variation in large granular lymphocyte leukemia | Characterization of a variant of PAC-1 in large granular lymphocyte leukemia.
Kothapalli R, Yoder SJ, Kusmartseva I, Loughran TP Jr. | 01/21/2010 |
| relationships between the expression levels of CD61, CD63, and PAC-1 on the platelet surface and the incidences of acute rejection and tubular necrosis as well as the recovery of graft function after renal transplantation | Relationship between the expression levels of CD61, CD63, and PAC-1 on platelet surface in peripheral blood and the transplanted kidney function.
Zhang Y, Guan DL, Xia CQ, Han ZY, Xu JJ, Gao JZ, Wu KR. | 01/21/2010 |