| Vascular protein disulfide isomerase A1 mediates endothelial dysfunction induced by angiotensin II in mice. | Vascular protein disulfide isomerase A1 mediates endothelial dysfunction induced by angiotensin II in mice.
Kij A, Bar A, Czyzynska-Cichon I, Przyborowski K, Proniewski B, Mateuszuk L, Kurylowicz Z, Jasztal A, Buczek E, Kurpinska A, Suraj-Prazmowska J, Marczyk B, Matyjaszczyk-Gwarda K, Daiber A, Oelze M, Walczak M, Chlopicki S. | 05/6/2024 |
| Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion. | Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion.
Chen Z, Wang S, Pottekat A, Duffey A, Jang I, Chang BH, Cho J, Finck BN, Davidson NO, Kaufman RJ., Free PMC Article | 02/20/2024 |
| Protein disulfide isomerase A1 as a novel redox sensor in VEGFR2 signaling and angiogenesis. | Protein disulfide isomerase A1 as a novel redox sensor in VEGFR2 signaling and angiogenesis.
Nagarkoti S, Kim YM, Ash D, Das A, Vitriol E, Read TA, Youn SW, Sudhahar V, McMenamin M, Hou Y, Boatwright H, Caldwell R, Essex DW, Cho J, Fukai T, Ushio-Fukai M., Free PMC Article | 02/14/2023 |
| A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of beta cell stress in type 1 diabetes. | A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes.
Syed F, Singhal D, Raedschelders K, Krishnan P, Bone RN, McLaughlin MR, Van Eyk JE, Mirmira RG, Yang ML, Mamula MJ, Wu H, Liu X, Evans-Molina C., Free PMC Article | 01/28/2023 |
| PDIA1 acts as master organizer of NOX1/NOX4 balance and phenotype response in vascular smooth muscle. | PDIA1 acts as master organizer of NOX1/NOX4 balance and phenotype response in vascular smooth muscle.
Fernandes DC, Wosniak J Jr, Gonçalves RC, Tanaka LY, Fernandes CG, Zanatta DB, de Mattos ABM, Strauss BE, Laurindo FRM. | 07/10/2021 |
| findings demonstrate that protein disulfide isomerase A1 (PDIA1/P4HB) contributes to oxidative maturation of proinsulin in the endoplasmic reticulum (ER) to support insulin production and ss cell health. | PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.
Jang I, Pottekat A, Poothong J, Yong J, Lagunas-Acosta J, Charbono A, Chen Z, Scheuner DL, Liu M, Itkin-Ansari P, Arvan P, Kaufman RJ., Free PMC Article | 03/7/2020 |
| this study uncovers a molecular link between PDIA1 and Drp1 oxidoreduction. | Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence.
Kim YM, Youn SW, Sudhahar V, Das A, Chandhri R, Cuervo Grajal H, Kweon J, Leanhart S, He L, Toth PT, Kitajewski J, Rehman J, Yoon Y, Cho J, Fukai T, Ushio-Fukai M., Free PMC Article | 12/14/2019 |
| these results suggest that overexpression of PDI may protect transplanted cells from hypoxia and other possibly occurring endoplasmic reticulum stresses, and consequently enhance their regenerative properties. | Protein disulfide isomerase as a prosurvival factor in cell therapy for muscular and vascular diseases.
Di Rocco G, Baldari S, Gentile A, Capogrossi M, Toietta G., Free PMC Article | 03/16/2019 |
| Neutrophil surface PDI is important for alphaMbeta2 integrin-mediated adhesion of human neutrophils under shear and static conditions and for binding of soluble fibrinogen to activated alphaMbeta2 integrin. | Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation.
Hahm E, Li J, Kim K, Huh S, Rogelj S, Cho J., Free PMC Article | 07/27/2013 |
| Unfolded protein response caused by protein misfolding, may lead to PDI-dependent NOX activation and contribute to neurotoxicity in neurodegenerative diseases including ALS. | Protein disulfide isomerase in ALS mouse glia links protein misfolding with NADPH oxidase-catalyzed superoxide production.
Jaronen M, Vehviläinen P, Malm T, Keksa-Goldsteine V, Pollari E, Valonen P, Koistinaho J, Goldsteins G. | 07/6/2013 |
| These results indicate that both endothelial and platelet beta3 integrins contribute to extracellular PDI binding at the vascular injury site. | Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins.
Cho J, Kennedy DR, Lin L, Huang M, Merrill-Skoloff G, Furie BC, Furie B., Free PMC Article | 10/6/2012 |
| PDI from endothelial cells is required for fibrin generation in vivo. | Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo.
Jasuja R, Furie B, Furie BC., Free PMC Article | 01/15/2011 |
| Protein disulfide isomerase (PDI) on the platelet surface is recognized by anti-dengue virus NS1 antibodies. | Anti-dengue virus nonstructural protein 1 antibodies recognize protein disulfide isomerase on platelets and inhibit platelet aggregation.
Cheng HJ, Lei HY, Lin CF, Luo YH, Wan SW, Liu HS, Yeh TM, Lin YS. | 01/21/2010 |