| Targeting DUSP5 suppresses malignant phenotypes of BRAF-mutant thyroid cancer cells and improves their response to sorafenib. | Targeting DUSP5 suppresses malignant phenotypes of BRAF-mutant thyroid cancer cells and improves their response to sorafenib.
Chen P, Wang J, Yao Y, Qu Y, Ji M, Hou P. | 08/12/2024 |
| Epithelial cells derived exosomal miR-203a-3p facilitates stromal inflammation of type IIIA chronic prostatitis/chronic pelvic pain syndrome by targeting DUSP5 and increasing MCP-1 generation. | Epithelial cells derived exosomal miR-203a-3p facilitates stromal inflammation of type IIIA chronic prostatitis/chronic pelvic pain syndrome by targeting DUSP5 and increasing MCP-1 generation.
Song G, Zhao F, Ni R, Deng B, Chen S, Hu R, Zheng J, Peng Y, Liu H, Luo Y, Zhou Z, Huang G, Shen W., Free PMC Article | 06/11/2024 |
| BAF53A drives colorectal cancer development by regulating DUSP5-mediated ERK phosphorylation. | BAF53A drives colorectal cancer development by regulating DUSP5-mediated ERK phosphorylation.
Yang Z, Huang D, Meng M, Wang W, Feng J, Fang L, Chen H, Zou S., Free PMC Article | 12/24/2022 |
| miR-203 suppresses pancreatic cancer cell proliferation and migration by modulating DUSP5 expression. | miR-203 suppresses pancreatic cancer cell proliferation and migration by modulating DUSP5 expression.
Altan Z, Sahin Y. | 12/10/2022 |
| METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression. | METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression.
Chen HD, Li F, Chen S, Zhong ZH, Gao PF, Gao WZ. | 07/23/2022 |
| Silencing of AFAP1-AS1 lncRNA impairs cell proliferation and migration by epigenetically promoting DUSP5 expression in pre-eclampsia. | Silencing of AFAP1-AS1 lncRNA impairs cell proliferation and migration by epigenetically promoting DUSP5 expression in pre-eclampsia.
Zhang S, Zou Y, Tang X, Zhang Y, Yang N, Xu K, Xu Y. | 02/19/2022 |
| Long non-coding RNA ARAP1-AS1 promotes the proliferation and migration in cervical cancer through epigenetic regulation of DUSP5. | Long non-coding RNA ARAP1-AS1 promotes the proliferation and migration in cervical cancer through epigenetic regulation of DUSP5.
Min H, He W., Free PMC Article | 10/23/2021 |
| DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy. | DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy.
Ferguson BS, Wennersten SA, Demos-Davies KM, Rubino M, Robinson EL, Cavasin MA, Stratton MS, Kidger AM, Hu T, Keyse SM, McKnight RA, Lane RH, Nozik ES, Weiser-Evans MCM, McKinsey TA., Free PMC Article | 09/25/2021 |
| DUSP5 suppresses interleukin-1beta-induced chondrocyte inflammation and ameliorates osteoarthritis in rats. | DUSP5 suppresses interleukin-1β-induced chondrocyte inflammation and ameliorates osteoarthritis in rats.
Wu Z, Xu L, He Y, Xu K, Chen Z, Moqbel SAA, Ma C, Jiang L, Ran J, Wu L, Zhong Y., Free PMC Article | 05/29/2021 |
| Integrated analysis identifies DUSP5 as a novel prognostic indicator for thyroid follicular carcinoma. | Integrated analysis identifies DUSP5 as a novel prognostic indicator for thyroid follicular carcinoma.
Zhang Q, Xing Y, Jiang S, Xu C, Zhou X, Zhang R, Xie T, Zou Z, Gong P, Zhu H, Zhang D, Ma H, Liao L, Dong J., Free PMC Article | 03/6/2021 |
| The long noncoding RNA H19 attenuates force-driven cartilage degeneration via miR-483-5p/Dusp5. | The long noncoding RNA H19 attenuates force-driven cartilage degeneration via miR-483-5p/Dusp5.
Wang CL, Zuo B, Li D, Zhu JF, Xiao F, Zhang XL, Chen XD. | 02/13/2021 |
| Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia. | Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia.
Chen LL, Zmuda EJ, Talavera MM, Frick J, Brock GN, Liu Y, Klebanoff MA, Trittmann JK., Free PMC Article | 01/30/2021 |
| Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1. | Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1.
Ohwada W, Tanno M, Yano T, Ong SB, Abe K, Sato T, Kuno A, Miki T, Sugawara H, Igaki Y, Miura T. | 12/12/2020 |
| Conserved Histidine and Serine in the HCXXXXXRS Motif of Human Dual-Specificity Phosphatase 5 | Role of Conserved Histidine and Serine in the HCXXXXXRS Motif of Human Dual-Specificity Phosphatase 5.
Gupta A, Brahmbhatt J, Syrlybaeva R, Bodnar C, Bodnar N, Bongard R, Pokkuluri PR, Sem DS, Ramchandran R, Rathore R, Talipov MR. | 06/6/2020 |
| DUSP5 expression is elevated in hepatocytes by ER stress through the PERK-CHOP pathway, contributing to hepatocyte death possibly through ERK inhibition. | Endoplasmic Reticulum Stress Increases DUSP5 Expression via PERK-CHOP Pathway, Leading to Hepatocyte Death.
Jo HJ, Yang JW, Park JH, Choi ES, Lim CS, Lee S, Han CY., Free PMC Article | 02/1/2020 |
| DUSP5 functions in the feedback inhibition of ERK1/2 signaling in response to TNFalpha, which resulted in increased inflammatory gene expression. | DUSP5 functions as a feedback regulator of TNFα-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes.
Habibian JS, Jefic M, Bagchi RA, Lane RH, McKnight RA, McKinsey TA, Morrison RF, Ferguson BS., Free PMC Article | 06/29/2019 |
| Data show that dual specificity phosphatase 5 (DUSP5) is a downstream target of p68 RNA helicase (p68). | P68 RNA helicase promotes invasion of glioma cells through negatively regulating DUSP5.
Wang R, Bao HB, Du WZ, Chen XF, Liu HL, Han DY, Wang LG, Wu JN, Wang CL, Yang MC, Liu ZW, Zhang N, Teng L., Free PMC Article | 01/19/2019 |
| Methylation the DUSP5 gene promoter can serve as an additional means of identifying CIMP-high colorectal cancers. | DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.
Tögel L, Nightingale R, Wu R, Chüeh AC, Al-Obaidi S, Luk I, Dávalos-Salas M, Chionh F, Murone C, Buchanan DD, Chatterton Z, Sieber OM, Arango D, Tebbutt NC, Williams D, Dhillon AS, Mariadason JM., Free PMC Article | 12/22/2018 |
| DUSP5 expression in skeletal muscle was ninefold higher immediately after exercise and returned to pre-exercise level within 2 h. | Dual specificity phosphatase 5 and 6 are oppositely regulated in human skeletal muscle by acute exercise.
Pourteymour S, Hjorth M, Lee S, Holen T, Langleite TM, Jensen J, Birkeland KI, Drevon CA, Eckardt K., Free PMC Article | 05/26/2018 |
| Findings indicate that zinc-finger protein X-linked (ZFX) promotes colorectal cancer (CRC) progression by suppressing dual specificity phosphatase 5 (DUSP5) expression and suggest that ZFX is a prognostic biomarker and potentially useful therapeutic target in stage II/III CRC patients. | High expression of Zinc-finger protein X-linked promotes tumor growth and predicts a poor outcome for stage II/III colorectal cancer patients.
Yan X, Shan Z, Yan L, Zhu Q, Liu L, Xu B, Liu S, Jin Z, Gao Y., Free PMC Article | 12/2/2017 |
| Results show that DUSP5 and DUSP6 mRNA are overexpressed in human PTCs, especially in BRAFV600E mutated papillary thyroid carcinomas (PTCs), and positively control cell migration and invasion. | DUSP5 and DUSP6, two ERK specific phosphatases, are markers of a higher MAPK signaling activation in BRAF mutated thyroid cancers.
Buffet C, Hecale-Perlemoine K, Bricaire L, Dumont F, Baudry C, Tissier F, Bertherat J, Cochand-Priollet B, Raffin-Sanson ML, Cormier F, Groussin L., Free PMC Article | 10/14/2017 |
| role of the secondary binding site in assembling the DUSP5-pERK pre-reactive complex was further demonstrated by molecular dynamics simulations that showed that the remote C197-C219 disulfide linkage controls the structure of the secondary binding pocket based on its redox state (i.e., disulfide/dithiol) and, in turn, the enzymatic activity of DUSP5 | Critical Role of the Secondary Binding Pocket in Modulating the Enzymatic Activity of DUSP5 toward Phosphorylated ERKs.
Talipov MR, Nayak J, Lepley M, Bongard RD, Sem DS, Ramchandran R, Rathore R. | 05/13/2017 |
| The DUSP5 S147P protein is hypoactive compared to the DUSP5 wild-type protein. | Protein expression, characterization and activity comparisons of wild type and mutant DUSP5 proteins.
Nayak J, Gastonguay AJ, Talipov MR, Vakeel P, Span EA, Kalous KS, Kutty RG, Jensen DR, Pokkuluri PR, Sem DS, Rathore R, Ramchandran R., Free PMC Article | 10/3/2015 |
| Data indicate that cells from Burkitt's lymphoma, leukemia, neuroblastoma and Ewing sarcoma showed a higher dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1)/dual specificity phosphatase 5 (DUSP5 ratio than normal cells. | Expression of dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1) in tumor cells.
Staege MS, Müller K, Kewitz S, Volkmer I, Mauz-Körholz C, Bernig T, Körholz D., Free PMC Article | 06/27/2015 |
| DUSP1, DUSP4, and DUSP5 differentially modulate endothelial MAPK signaling pathways downstream of Tie-2 receptors. | Regulation of angiopoietin-1/Tie-2 receptor signaling in endothelial cells by dual-specificity phosphatases 1, 4, and 5.
Echavarria R, Hussain SN., Free PMC Article | 06/21/2014 |