| Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease. | Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease.
Beamish JA, Telang AC, McElliott MC, Al-Suraimi A, Chowdhury M, Ference-Salo JT, Otto EA, Menon R, Soofi A, Weinberg JM, Patel SR, Dressler GR., | 02/2/2024 |
| Pax8 and Nkx2-1 haploinsufficiencies differentially affect liver metabolic pathways. | Pax8 and Nkx2-1 haploinsufficiencies differentially affect liver metabolic pathways.
Giacco A, Peluso T, Cioffi F, Iervolino S, Mercurio G, Roberto L, Reale C, Colella M, De Felice M, Moreno M, Ambrosino C, Silvestri E. | 04/30/2022 |
| Cells expressing PAX8 are the main source of homeostatic regeneration of adult mouse endometrial epithelium and give rise to serous endometrial carcinoma. | Cells expressing PAX8 are the main source of homeostatic regeneration of adult mouse endometrial epithelium and give rise to serous endometrial carcinoma.
Fu DJ, De Micheli AJ, Bidarimath M, Ellenson LH, Cosgrove BD, Flesken-Nikitin A, Nikitin AY., Free PMC Article | 10/2/2021 |
| PAX8 is a unifying protein driving metastasis in ovarian tumors that could be developed as an effective drug target to treat High Grade serous ovarian cancer derived from both the Ovarian surface epithelium and Fallopian tube epithelium. | Proteomic analysis reveals a role for PAX8 in peritoneal colonization of high grade serous ovarian cancer that can be targeted with micelle encapsulated thiostrepton.
Hardy LR, Pergande MR, Esparza K, Heath KN, Önyüksel H, Cologna SM, Burdette JE., Free PMC Article | 02/1/2020 |
| Results show that in both 3- and 8-week-old offspring of the maternal group highly treated with E2, Pax8 was significantly up-regulated in thyroid glands, accompanied by the abnormal CpG island methylation status in the promoter region. | Maternal High Estradiol Exposure is Associated with Elevated Thyroxine and Pax8 in Mouse Offspring.
Lv PP, Tian S, Feng C, Li JY, Yu DQ, Jin L, Shen Y, Yu TT, Meng Y, Ding GL, Jin M, Chen XJ, Sheng JZ, Zhang D, Huang HF., Free PMC Article | 05/19/2018 |
| Demonstrate the stepwise emergence of hitherto undescribed, differently Pax2/Pax8- coded anterior and posterior subdomains in the posterior placodal area of mice. | Pax2/Pax8-defined subdomains and the occurrence of apoptosis in the posterior placodal area of mice.
Washausen S, Knabe W. | 02/3/2018 |
| PAX8 has a cell specific role in governing proliferation and migration in nontransformed ovarian surface epithelium cells compared to the oviductal cells, but its reduction in serous cancer cell lines provides a common mechanism for reducing cell survival. | Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium.
Rodgers LH, Ó hAinmhire E, Young AN, Burdette JE., Free PMC Article | 12/30/2017 |
| These results suggest that Pax8 maybe the downstream molecule of ALK3, it mediates the murine heart development via cellular senescence, which may serve as a mechanism that compensates for the cell loss via apoptosis in heart development. | Pax8 plays a pivotal role in regulation of cardiomyocyte growth and senescence.
Wu Y, Zhou X, Huang X, Xia Q, Chen Z, Zhang X, Yang D, Geng YJ., Free PMC Article | 01/14/2017 |
| Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure | Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure.
Bartram MP, Amendola E, Benzing T, Schermer B, de Vita G, Müller RU., Free PMC Article | 10/22/2016 |
| PAX8 protein expression was associated with germinal layers in human and murine forebrain and hindbrain development. | Paired box gene 8 (PAX8) expression is associated with sonic hedgehog (SHH)/wingless int (WNT) subtypes, desmoplastic histology and patient survival in human medulloblastomas.
Harter PN, Baumgarten P, Zinke J, Schilling K, Baader S, Hartmetz AK, Schittenhelm J, Beschorner R, Liebner S, Schulte D, Plate KH, Gutwein P, Korshunov A, Pfister SM, Jones DT, Doberstein K, Mittelbronn M. | 01/2/2016 |
| Pax8 is essential for function and survival of adult thyroid cells. | The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.
Marotta P, Amendola E, Scarfò M, De Luca P, Zoppoli P, Amoresano A, De Felice M, Di Lauro R. | 05/23/2015 |
| a core regulatory subcircuit composed of Pax2/8, Gata3 and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization. | A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis.
Boualia SK, Gaitan Y, Tremblay M, Sharma R, Cardin J, Kania A, Bouchard M. | 12/14/2013 |
| The Pax8 promoter appears to be autoregulated, a feature that might be responsible for the haploinsufficiency displayed by this gene. | Functional analysis of the murine Pax8 promoter reveals autoregulation and the presence of a novel thyroid-specific DNA-binding activity.
di Gennaro A, Spadaro O, Baratta MG, De Felice M, Di Lauro R. | 09/21/2013 |
| Inducible, Pax8-rtTA-based deletion of VHL leads to organ-specific expression of epithelial HIF and erythropoietin in liver and kidney without causing pathological changes. | Action of hypoxia-inducible factor in liver and kidney from mice with Pax8-rtTA-based deletion of von Hippel-Lindau protein.
Mathia S, Paliege A, Koesters R, Peters H, Neumayer HH, Bachmann S, Rosenberger C. | 08/3/2013 |
| study concludes that Cadherin-16 is a novel downstream target of the transcription factor Pax8, likely since the early steps of thyroid development, and that its expression is associated with the fully differentiated state of the thyroid cell | An essential role for Pax8 in the transcriptional regulation of cadherin-16 in thyroid cells.
de Cristofaro T, Di Palma T, Fichera I, Lucci V, Parrillo L, De Felice M, Zannini M., Free PMC Article | 07/7/2012 |
| Study shows that Pax2;8 double null mice do not develop an ear past the otocyst stage and no sensory and limited neuronal development; these 2 family members are essential for overall ear morphogenesis and sustained neurosensory development. | Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation.
Bouchard M, de Caprona D, Busslinger M, Xu P, Fritzsch B., Free PMC Article | 11/27/2010 |
| a thyroid-specific regulatory element in the 5' upstream region of the Pax8 gene | Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene.
Nitsch R, Di Dato V, di Gennaro A, de Cristofaro T, Abbondante S, De Felice M, Zannini M, Di Lauro R., Free PMC Article | 09/6/2010 |
| A 6h exposure to Tg resulted in increases of about 5-fold in TGF-beta1 and PAI-1 mRNA and a decrease of 53% in Pax-8. | TGF-beta-like transcriptional effects of thyroglobulin (Tg) in mouse mesangial cells.
Sellitti DF, Puggina E, Lagranha C, Doi S, Pithon-Curi T, Kohn LD, Suzuki K. | 01/21/2010 |
| Pax8(-/-)TRalpha1(-/-) compound mutants die around weaning unless they are substituted with thyroid hormones. Short life span of Pax8(-/-) mice due to complex mechanism involving TRalpha2 and an unliganded TR isoform. | Athyroid Pax8-/- mice cannot be rescued by the inactivation of thyroid hormone receptor alpha1.
Mittag J, Friedrichsen S, Heuer H, Polsfuss S, Visser TJ, Bauer K. | 01/21/2010 |
| Pax8 expression not only in the uterine epithelium of mice but also in the human endometrium. Adequate development of uterus may be affected in congenital hypothyroid female patients with mutations in Pax8 gene. | Congenital hypothyroid female pax8-deficient mice are infertile despite thyroid hormone replacement therapy.
Mittag J, Winterhager E, Bauer K, Grümmer R. | 01/21/2010 |
| a crucial role for Pax2 and Pax8 in nephron differentiation and branching morphogenesis of the metanephros. | Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney.
Narlis M, Grote D, Gaitan Y, Boualia SK, Bouchard M. | 01/21/2010 |
| these data identify Pax2 and Pax8 as critical regulators that specify the nephric lineage. | Nephric lineage specification by Pax2 and Pax8.
Bouchard M, Souabni A, Mandler M, Neubüser A, Busslinger M., Free PMC Article | 01/21/2010 |
| Combination of partial deficiencies in the Titf1 and Pax8 genes results in an overt thyroid dysgenesis phenotype that is absent in either of the singly deficient, heterozygous mice. | A mouse model demonstrates a multigenic origin of congenital hypothyroidism.
Amendola E, De Luca P, Macchia PE, Terracciano D, Rosica A, Chiappetta G, Kimura S, Mansouri A, Affuso A, Arra C, Macchia V, Di Lauro R, De Felice M. | 01/21/2010 |
| The Box protein Pax-8 gene is an important and cardiac-specific ALK3 downstream gene in the BMP signaling pathway during inter-ventricular septum development. | [A study on myocardial Pax-8 gene].
Yang DY, Song HY, Zhang HQ, Huang XY, Li SG, Guan XQ. | 01/21/2010 |