| PIMT is a novel and potent suppressor of endothelial activation. | PIMT is a novel and potent suppressor of endothelial activation.
Zhang C, Guo ZF, Liu W, Kazama K, Hu L, Sun X, Wang L, Lee H, Lu L, Yang XF, Summer R, Sun J., Free PMC Article | 04/26/2023 |
| Loss of normal CKB structure and function contributes to the mechanisms by which isoaspartate accumulation leads to central nervous system dysfunction in the PIMT-Knockout mouse. | Isoaspartyl formation in creatine kinase B is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse.
Dimitrijevic A, Qin Z, Aswad DW., Free PMC Article | 10/17/2015 |
| PIMT levels may significantly influence the course of age-related central nervous system dysfunction. | Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human aging.
Qin Z, Dimitrijevic A, Aswad DW., Free PMC Article | 09/26/2015 |
| ERK2-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP at Ser298 augments hepatic gluconeogenesis. | ERK2-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP at Ser298 augments hepatic gluconeogenesis.
Kapadia B, Viswakarma N, Parsa KV, Kain V, Behera S, Suraj SK, Babu PP, Kar A, Panda S, Zhu YJ, Jia Y, Thimmapaya B, Reddy JK, Misra P., Free PMC Article | 09/20/2014 |
| PIMT knockout mice have perturbations in glutamate metabolism in the brain and die prematurely of epileptic seizures. | Brain proteomics supports the role of glutamate metabolism and suggests other metabolic alterations in protein l-isoaspartyl methyltransferase (PIMT)-knockout mice.
Yang H, Lowenson JD, Clarke S, Zubarev RA., Free PMC Article | 05/10/2014 |
| synuclein is not a major target of PIMT in vivo | Considerations in the identification of endogenous substrates for protein L-isoaspartyl methyltransferase: the case of synuclein.
Morrison GJ, Ganesan R, Qin Z, Aswad DW., Free PMC Article | 02/16/2013 |
| Pcmt1-/- mice have an increased number of granule cells in the granule cell layer and hilus of the dentate gyrus. | Increased cell proliferation and granule cell number in the dentate gyrus of protein repair-deficient mice.
Farrar CE, Huang CS, Clarke SG, Houser CR. | 01/21/2010 |
| An accumulation of isoaspartyl residues in cells of mice lacking the isoaspartyl repair enzyme PCMT alters the effector function of T lymphocytes leading to autoantibody production. | A failure to repair self-proteins leads to T cell hyperproliferation and autoantibody production.
Doyle HA, Gee RJ, Mamula MJ. | 01/21/2010 |
| Recombinant adeno-PIMT improved the symptoms of PIMT-deficient mice in vivo, but only partially repaired IsoAsp in damaged proteins. | Adenoviral expression of protein-L-isoaspartyl methyltransferase (PIMT) partially attenuates the biochemical changes in PIMT-deficient mice.
Ogawara M, Takahashi M, Shimizu T, Nakajima M, Setoguchi Y, Shirasawa T. | 01/21/2010 |
| Synapsin I is a major endogenous substrate for Pcmt1 in the mouse brain. | Synapsin I is a major endogenous substrate for protein L-isoaspartyl methyltransferase in mammalian brain.
Reissner KJ, Paranandi MV, Luc TM, Doyle HA, Mamula MJ, Lowenson JD, Aswad DW. | 01/21/2010 |
| Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of PCMT1 knockout mice | Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-Aspartyl) O-methyltransferase-deficient mice.
Farrar C, Clarke S. | 01/21/2010 |
| Pcmt1-/- mice have altered regulation of the insulin pathway, possibly as a compensatory response to altered glucose uptake or metabolism or as an adaptive response to a general accumulation of isoaspartyl protein damage in the brain and other tissues. | Activation of the PI3K/Akt signal transduction pathway and increased levels of insulin receptor in protein repair-deficient mice.
Farrar C, Houser CR, Clarke S. | 01/21/2010 |
| PIMT-KO phenotype results from the cumulative effect of isoaspartate-related damage to a number of the neuron-rich proteins detected in this study | Protein repair in the brain, proteomic analysis of endogenous substrates for protein L-isoaspartyl methyltransferase in mouse brain.
Zhu JX, Doyle HA, Mamula MJ, Aswad DW. | 01/21/2010 |
| Protein L-isoaspartyl methyltransferase (PIMT) catalyzes in vivo racemization of Asp-25 in mammalian histone H2B, suggesting that PIMT functions in the repair, rather than the metabolic turnover, of isoaspartyl proteins in vivo. | Protein L-isoaspartyl methyltransferase catalyzes in vivo racemization of Aspartate-25 in mammalian histone H2B.
Young GW, Hoofring SA, Mamula MJ, Doyle HA, Bunick GJ, Hu Y, Aswad DW. | 01/21/2010 |