| These observations suggest that PC-TP promotes liver injury by mediating the intermembrane transfer of phosphatidylcholines, thus stabilizing more pathogenic microvesicular lipid droplets. | Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis.
Nicholls HT, Hornick JL, Cohen DE., Free PMC Article | 08/19/2017 |
| Improved glucose tolerance in Pctp(-/-);ob/ob mice in the absence of increases in energy expenditure or core body temperature indicates a direct pathogenic role for Phosphatidylcholine transfer protein in diabetes in leptin deficient mice | Genetic ablation of phosphatidylcholine transfer protein/StarD2 in ob/ob mice improves glucose tolerance without increasing energy expenditure.
Krisko TI, LeClair KB, Cohen DE., Free PMC Article | 05/27/2017 |
| Them2 and phosphatidylcholine transfer protein regulate lipid and glucose metabolism | Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization.
Kawano Y, Ersoy BA, Li Y, Nishiumi S, Yoshida M, Cohen DE., Free PMC Article | 08/9/2014 |
| PC-TP-THEM2 complex reduces phosphorylation and stability of IRS2 and increases stability of the TSC1-TSC2 complex | Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling.
Ersoy BA, Tarun A, D'Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD, Cohen DE., Free PMC Article | 02/22/2014 |
| Findings support a key role for Pctp in limiting mitochondrial oxidation of fatty acids and thus regulating adaptive thermogenesis in BAT. | Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue.
Kang HW, Ribich S, Kim BW, Hagen SJ, Bianco AC, Cohen DE., Free PMC Article | 03/22/2010 |
| data support a key biological role for PCTP in the regulation of energy substrate utilization, reflecting increased hepatic triglyceride production in knockout mice. | Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2.
Scapa EF, Pocai A, Wu MK, Gutierrez-Juarez R, Glenz L, Kanno K, Li H, Biddinger S, Jelicks LA, Rossetti L, Cohen DE. | 01/21/2010 |
| Yeast two-hybrid screening using libraries prepared from mouse liver and embryo identified Them2 (thioesterase superfamily member 2) and the homeodomain transcription factor Pax3 (paired box gene 3), respectively, as PC-TP-interacting proteins. | Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2.
Kanno K, Wu MK, Agate DS, Fanelli BJ, Wagle N, Scapa EF, Ukomadu C, Cohen DE. | 01/21/2010 |
| PC-TP modulates the development of atherosclerosis, in part by regulating plasma lipid concentrations | Homozygous disruption of Pctp modulates atherosclerosis in apolipoprotein E-deficient mice.
Wang WJ, Baez JM, Maurer R, Dansky HM, Cohen DE. | 01/21/2010 |
| NZO-derived PC-TP contained a non-synonymous point mutation that resulted in an Arg120His substitution, which was shared by the related NZB/BlNJ and NZW/LacJ mouse strains. | A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein.
Pan HJ, Agate DS, King BL, Wu MK, Roderick SL, Leiter EH, Cohen DE., Free PMC Article | 01/21/2010 |
| In Pctp(-/-) mice, there was an accumulation of small alpha-migrating HDL particles. PC-TP participates in HDL reverse cholesterol transport. | Phosphatidylcholine transfer protein regulates size and hepatic uptake of high-density lipoproteins.
Wu MK, Cohen DE. | 01/21/2010 |
| regulation of cholesterol homeostasis is a physiological function of PC-TP in liver, which can be overcome with a cholesterol-rich lithogenic diet | Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice.
Wu MK, Cohen DE. | 01/21/2010 |