| Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression. | Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression.
Cheng J, Yuan L, Yu S, Gu B, Luo Q, Wang X, Zhao Y, Gai C, Li T, Liu W, Wang Z, Liu D, Ho RCM, Ho CSH. | 06/8/2024 |
| Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARgamma/IL-10 signaling. | Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling.
Li Y, Zhan B, Zhuang X, Zhao M, Chen X, Wang Q, Liu Q, Zhang L., Free PMC Article | 06/7/2024 |
| PDCD4 deficiency improved 4-vinylcyclohexene dioxide-induced mouse premature ovarian insufficiency. | PDCD4 deficiency improved 4-vinylcyclohexene dioxide-induced mouse premature ovarian insufficiency.
Zhang J, Qin M, Kao C, Shi Y, Yang Z, Chen T, Liu M, Fang L, Gao F, Qin Y, Ding L. | 05/9/2024 |
| MiR-181a protects the heart against myocardial infarction by regulating mitochondrial fission via targeting programmed cell death protein 4. | MiR-181a protects the heart against myocardial infarction by regulating mitochondrial fission via targeting programmed cell death protein 4.
Zhu J, Wang Q, Zheng Z, Ma L, Guo J, Shi H, Ying R, Gao B, Chen S, Yu S, Yuan B, Peng X, Ge J., Free PMC Article | 03/21/2024 |
| [PDCD4 knockdown ameliorates lipopolysaccharide-induced endothelial cell damage by improving mitochondrial dynamics]. | [PDCD4 knockdown ameliorates lipopolysaccharide-induced endothelial cell damage by improving mitochondrial dynamics].
Yu J, Li R, Xia T, Wang J, Jin J, Yuan M, Li M., Free PMC Article | 02/8/2024 |
| CircRBM33 induces endothelial dysfunction by targeting the miR-6838-5p/PDCD4 axis affecting blood-brain barrier in mice with cerebral ischemia-reperfusion injury. | CircRBM33 induces endothelial dysfunction by targeting the miR-6838-5p/PDCD4 axis affecting blood-brain barrier in mice with cerebral ischemia-reperfusion injury.
Zhang Y, Yuan X, Xu J, Gu H. | 01/13/2024 |
| Programmed cell death 4 governs NLRP3-mediated pyroptosis in septic lung disorders. | Programmed cell death 4 governs NLRP3-mediated pyroptosis in septic lung disorders.
Du W, Ren N, Xu Y, Chen X. | 01/10/2024 |
| miR-208 inhibits myocardial tissues apoptosis in mice with acute myocardial infarction by targeting inhibition of PDCD4. | miR-208 inhibits myocardial tissues apoptosis in mice with acute myocardial infarction by targeting inhibition of PDCD4.
Wang Q, Zhou H, Zhu X, Jiang F, Yu Q, Zhang J, Ji Y. | 12/24/2022 |
| PDCD4 Simultaneously Promotes Microglia Activation via PDCD4-MAPK-NF-kappaB Positive Loop and Facilitates Neuron Apoptosis During Neuroinflammation. | PDCD4 Simultaneously Promotes Microglia Activation via PDCD4-MAPK-NF-κB Positive Loop and Facilitates Neuron Apoptosis During Neuroinflammation.
Chen Q, Lu H, Duan C, Zhu X, Zhang Y, Li M, Zhang D. | 03/26/2022 |
| Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5. | Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5.
Osoro EK, Du X, Liang D, Lan X, Farooq R, Huang F, Zhu W, Ren J, Sadiq M, Tian L, Yang X, Li D, Lu S. | 01/8/2022 |
| LncRNA HOTAIR Promotes LPS-Induced Inflammation and Apoptosis of Cardiomyocytes via Lin28-Mediated PDCD4 Stability. | LncRNA HOTAIR Promotes LPS-Induced Inflammation and Apoptosis of Cardiomyocytes via Lin28-Mediated PDCD4 Stability.
Ni SY, Xu WT, Liao GY, Wang YL, Li J. | 12/25/2021 |
| MicroRNA expression in lung tissues of asbestos-exposed mice: Upregulation of miR-21 and downregulation of tumor suppressor genes Pdcd4 and Reck. | MicroRNA expression in lung tissues of asbestos-exposed mice: Upregulation of miR-21 and downregulation of tumor suppressor genes Pdcd4 and Reck.
Hiraku Y, Watanabe J, Kaneko A, Ichinose T, Murata M., Free PMC Article | 11/13/2021 |
| MicroRNA421 attenuates macrophagemediated inflammation by inhibiting PDCD4 in vitro. | MicroRNA‑421 attenuates macrophage‑mediated inflammation by inhibiting PDCD4 in vitro.
Liu H, Sun J, Gao L, Fan L, Chen D, Wu L. | 10/16/2021 |
| Programmed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression. | Programmed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression.
Li Y, Jia Y, Wang D, Zhuang X, Li Y, Guo C, Chu H, Zhu F, Wang J, Wang X, Wang Q, Zhao W, Shi Y, Chen W, Zhang L., Free PMC Article | 10/16/2021 |
| Mesenchymal stem cells-derived exosomal microRNA-21-5p downregulates PDCD4 and ameliorates erectile dysfunction in a rat model of diabetes mellitus. | Mesenchymal stem cells-derived exosomal microRNA-21-5p downregulates PDCD4 and ameliorates erectile dysfunction in a rat model of diabetes mellitus.
Huo W, Li Y, Zhang Y, Li H. | 05/1/2021 |
| PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses. | PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.
Di Paolo A, Eastman G, Mesquita-Ribeiro R, Farias J, Macklin A, Kislinger T, Colburn N, Munroe D, Sotelo Sosa JR, Dajas-Bailador F, Sotelo-Silveira JR., Free PMC Article | 01/23/2021 |
| miR-21a in exosomes from Lewis lung carcinoma cells accelerates tumor growth through targeting PDCD4 to enhance expansion of myeloid-derived suppressor cells. | miR-21a in exosomes from Lewis lung carcinoma cells accelerates tumor growth through targeting PDCD4 to enhance expansion of myeloid-derived suppressor cells.
Zhang X, Li F, Tang Y, Ren Q, Xiao B, Wan Y, Jiang S. | 12/12/2020 |
| miR-21 was significantly upregulated in activated fibroblasts and that it maintained itself at constant high levels by employing an auto-regulatory loop between miR-21, PDCD4 and AP-1. | The feedback loop between miR-21, PDCD4 and AP-1 functions as a driving force for renal fibrogenesis.
Sun Q, Miao J, Luo J, Yuan Q, Cao H, Su W, Zhou Y, Jiang L, Fang L, Dai C, Zen K, Yang J. | 10/26/2019 |
| Results found that PDCD4, a validated target of miR-21, was highly expressed in both injured kidney tissues and LPS-stimulated TKPTS cells. Meanwhile, the protein expression of PDCD4 was significantly reduced by inhibition of MEG3, but retrieved by co-inhibition of MEG3 and miR-21. | Inhibition of maternally expressed gene 3 attenuated lipopolysaccharide-induced apoptosis through sponging miR-21 in renal tubular epithelial cells.
Yang R, Liu S, Wen J, Xue L, Zhang Y, Yan D, Wang G, Liu Z. | 10/12/2019 |
| icroRNA-21 mediates high Pi-induced endothelial cell apoptosis, which involves an ERK1/2/microRNA-21/PDCD4 pathway. High Pi-induced downregulation of NF-kappaB expression is mediated by an ERK1/2 signaling-dependent but microRNA-21-independent mechanism | MicroRNA-21 mediates high phosphate-induced endothelial cell apoptosis.
Li Z, Wiernek S, Patterson C, Wang H, Qi G, Dai X., Free PMC Article | 07/13/2019 |
| MALAT1-miR-200a-3p-PDCD4 axis regulated the proliferation. | Long non-coding RNA MALAT1 regulates cardiomyocytes apoptosis after hypoxia/reperfusion injury via modulating miR-200a-3p/PDCD4 axis.
Sun R, Zhang L. | 06/22/2019 |
| We identify PDCD4 as an important ubiquitination substrate of SKP2 | SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination.
Li C, Du L, Ren Y, Liu X, Jiao Q, Cui D, Wen M, Wang C, Wei G, Wang Y, Ji A, Wang Q., Free PMC Article | 06/1/2019 |
| These skeletal effects were attributed to inhibition of bone resorption and osteoclast function by miR-21 deficiency through miR-21 targeting programmed cell death 4 (PDCD4), despite the existence of RANKL. As far as we know, this is the first in vivo evidence of a pro-osteoclastic microRNA. | miR-21 deficiency inhibits osteoclast function and prevents bone loss in mice.
Hu CH, Sui BD, Du FY, Shuai Y, Zheng CX, Zhao P, Yu XR, Jin Y., Free PMC Article | 11/17/2018 |
| MEG3 functions as a competing endogenous RNAs (ceRNAs) and competes with PDCD4 mRNA for directly binding to miR-21, which mediates ischemic neuronal death. | Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway.
Yan H, Rao J, Yuan J, Gao L, Huang W, Zhao L, Ren J., Free PMC Article | 07/21/2018 |
| In colorectal cancer tissues, the Sin1 protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 protein level but not mRNA level in colorectal cancer. | Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma.
Wang Q, Zhu J, Wang YW, Dai Y, Wang YL, Wang C, Liu J, Baker A, Colburn NH, Yang HS., Free PMC Article | 12/2/2017 |