| [Prdx1 regulates macrophage polarization by maintaining mitochondrial homeostasis]. | [Prdx1 regulates macrophage polarization by maintaining mitochondrial homeostasis].
Zhang X, Zhang Z, Qi Y, Zhang X, Yin S. | 06/7/2024 |
| PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent Ca[2+] homeostasis in sensory neurons. | PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent Ca(2+) homeostasis in sensory neurons.
Saloman JL, Epouhe AY, Ruff CF, Albers KM., | 05/29/2024 |
| Repression of latent NF-kappaB enhancers by PDX1 regulates beta cell functional heterogeneity. | Repression of latent NF-κB enhancers by PDX1 regulates β cell functional heterogeneity.
Weidemann BJ, Marcheva B, Kobayashi M, Omura C, Newman MV, Kobayashi Y, Waldeck NJ, Perelis M, Lantier L, McGuinness OP, Ramsey KM, Stein RW, Bass J., | 01/10/2024 |
| Pdx1 expression in hematopoietic cells activates Kras-mutation to drive leukemia in KC (Pdx1-Cre; LSL-Kras[G12D/+]) mice. | Pdx1 expression in hematopoietic cells activates Kras-mutation to drive leukemia in KC (Pdx1-Cre; LSL-Kras(G12D/+)) mice.
Walcheck MT, Nukaya M, Ranheim EA, Matkowskyj KA, Ronnekleiv-Kelly S., Free PMC Article | 06/13/2023 |
| PIMT Controls Insulin Synthesis and Secretion through PDX1. | PIMT Controls Insulin Synthesis and Secretion through PDX1.
Sharma R, Maity SK, Chakrabarti P, Katika MR, Kapettu S, Parsa KVL, Misra P., Free PMC Article | 06/7/2023 |
| Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion. | Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion.
Wong A, Pritchard S, Moore M, Akhaphong B, Avula N, Beetch M, Fujitani Y, Alejandro EU., Free PMC Article | 02/27/2023 |
| Intracellular ATP Signaling Contributes to FAM3A-Induced PDX1 Upregulation in Pancreatic Beta Cells. | Intracellular ATP Signaling Contributes to FAM3A-Induced PDX1 Upregulation in Pancreatic Beta Cells.
Yan H, Chen Z, Zhang H, Yang W, Liu X, Meng Y, Xiang R, Wu Z, Ye J, Chi Y, Yang J., Free PMC Article | 08/20/2022 |
| Pancreatic-Like Cells Derived From Mouse Embryonic Stem Cells Are Regulated by Pdx1 Involving the Notch Pathway. | Pancreatic-Like Cells Derived From Mouse Embryonic Stem Cells Are Regulated by Pdx1 Involving the Notch Pathway.
Zhong W, Lai Y, Xia ZS, Lin Y, Ni CY, Yu Z, Li JY, Yu T, Chen QK. | 07/9/2022 |
| Islet transplantation into brown adipose tissue can delay immune rejection. | Islet transplantation into brown adipose tissue can delay immune rejection.
Kepple JD, Barra JM, Young ME, Hunter CS, Tse HM., Free PMC Article | 04/2/2022 |
| Coxsackievirus B Type 4 Infection in beta Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing. | Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing.
Bernard H, Teijeiro A, Chaves-Pérez A, Perna C, Satish B, Novials A, Wang JP, Djouder N., Free PMC Article | 02/26/2022 |
| Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function. | Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function.
Zhang M, Yang C, Zhu M, Qian L, Luo Y, Cheng H, Geng R, Xu X, Qian C, Liu Y. | 02/26/2022 |
| OGT Regulates Mitochondrial Biogenesis and Function via Diabetes Susceptibility Gene Pdx1. | OGT Regulates Mitochondrial Biogenesis and Function via Diabetes Susceptibility Gene Pdx1.
Mohan R, Jo S, Lockridge A, Ferrington DA, Murray K, Eschenlauer A, Bernal-Mizrachi E, Fujitani Y, Alejandro EU., Free PMC Article | 01/1/2022 |
| Sex-dependent development of Kras-induced anal squamous cell carcinoma in mice. | Sex-dependent development of Kras-induced anal squamous cell carcinoma in mice.
Walcheck MT, Matkowskyj KA, Turco A, Blaine-Sauer S, Nukaya M, Noel J, Ronnekleiv OK, Ronnekleiv-Kelly SM., Free PMC Article | 12/25/2021 |
| Development of thymic tumor in [LSL:Kras(G12D); Pdx1-CRE] mice, an adverse effect associated with accelerated pancreatic carcinogenesis. | Development of thymic tumor in [LSL:Kras(G12D); Pdx1-CRE] mice, an adverse effect associated with accelerated pancreatic carcinogenesis.
Liot S, El Kholti N, Balas J, Genestier L, Verrier B, Valcourt U, Lambert E., Free PMC Article | 11/6/2021 |
| Premalignant pancreatic cells seed stealth metastasis in distant organs in mice. | Premalignant pancreatic cells seed stealth metastasis in distant organs in mice.
Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T, Ochiai Y, Nagino M. | 10/16/2021 |
| Acarbose ameliorates spontaneous type2 diabetes in db/db mice by inhibiting PDX1 methylation. | Acarbose ameliorates spontaneous type‑2 diabetes in db/db mice by inhibiting PDX‑1 methylation.
Zhou D, Chen L, Mou X., Free PMC Article | 05/8/2021 |
| Tectorigenin enhances PDX1 expression and protects pancreatic beta-cells by activating ERK and reducing ER stress. | Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress.
Yao X, Li K, Liang C, Zhou Z, Wang J, Wang S, Liu L, Yu CL, Song ZB, Bao YL, Zheng LH, Sun Y, Wang G, Huang Y, Yi J, Sun L, Li Y., Free PMC Article | 02/2/2021 |
| LncRNA MALAT1 induces the dysfunction of beta cells via reducing the histone acetylation of the PDX-1 promoter in type 1 diabetes. | LncRNA MALAT1 induces the dysfunction of β cells via reducing the histone acetylation of the PDX-1 promoter in type 1 diabetes.
Ding H, Wang F, Shi X, Ma H, Du Y, Hou L, Xing N. | 10/31/2020 |
| Findings indicate that intracellular stress caused by Pdx1 inactivation triggers the senescence-associated secretory phenotype to maintain organ homeostasis. | Senescence caused by inactivation of the homeodomain transcription factor Pdx1 in adult pancreatic acinar cells in mice.
Horiguchi M, Yoshida M, Hirata K, Furuyama K, Masui T, Uemoto S, Kawaguchi Y. | 06/6/2020 |
| PDX1 expression is maintained via the Erk pathway and protects islet beta-cells against glucotoxicity and lipotoxicity | Hypericin maintians PDX1 expression via the Erk pathway and protects islet β-cells against glucotoxicity and lipotoxicity.
Liang C, Hao F, Yao X, Qiu Y, Liu L, Wang S, Yu C, Song Z, Bao Y, Yi J, Huang Y, Wu Y, Zheng L, Sun Y, Wang G, Yang X, Yang S, Sun L, Li Y., Free PMC Article | 04/18/2020 |
| GPR120 activation is protective against lipotoxicity-induced pancreatic beta-cell dysfunction, by mediation of PDX1 expression and inhibition of islet inflammation. | GPR120 protects lipotoxicity-induced pancreatic β-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation.
Wang Y, Xie T, Zhang D, Leung PS. | 10/26/2019 |
| Results identify a novel PDX1 stress inducible complex (es) that regulates expression of stress and apoptosis genes to govern beta cell survival. | A PDX1-ATF transcriptional complex governs β cell survival during stress.
Juliana CA, Yang J, Cannon CE, Good AL, Haemmerle MW, Stoffers DA., Free PMC Article | 09/14/2019 |
| Tsc1-mTORC1 pathway plays an important role in mediating the decrease in beta-cell proliferation and growth and the reduction in beta-cell mass that occurs in Pdx1-deficient diabetes. | Critical role for the Tsc1-mTORC1 pathway in β-cell mass in Pdx1-deficient mice.
Sun J, Mao L, Yang H, Ren D., Free PMC Article | 08/24/2019 |
| Here, using a pancreatic determination gene, Pdx1, driven GFP transgenic mouse strain, we identified Pdx1-GFP highly expressing cells (Pdx1(high)) and Pdx1-GFP lowly expressing cells (Pdx1(low)) in both embryonic dorsal Pdx1-expressing region (DPR) and ventral Pdx1-expressing region (VPR) | Single-cell transcriptomic analyses reveal distinct dorsal/ventral pancreatic programs.
Li LC, Qiu WL, Zhang YW, Xu ZR, Xiao YN, Hou C, Lamaoqiezhong, Yu P, Cheng X, Xu CR., Free PMC Article | 06/8/2019 |
| Ffar1 expression is markedly down-regulated under diabetic conditions which is accompanied by decreased expression of Pdx1. Furthermore, it is likely that Pdx1 is a regulator of Ffar1 expression in beta-cells. | Suppression of free fatty acid receptor 1 expression in pancreatic β-cells in obese type 2 diabetic db/db mice: a potential role of pancreatic and duodenal homeobox factor 1.
Kohara K, Obata A, Kimura T, Shimoda M, Moriuchi S, Okauchi S, Hirukawa H, Mune T, Kaku K, Kaneto H. | 05/18/2019 |