| Molecular Insights of Cholestasis in MDR2 Knockout Murine Liver Organoids. | Molecular Insights of Cholestasis in MDR2 Knockout Murine Liver Organoids.
Blázquez-García I, Guerrero L, Cacho-Navas C, Djouder N, Millan J, Paradela A, Carmona-Rodríguez L, Corrales FJ., Free PMC Article | 04/11/2024 |
| Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice. | Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice.
Furukawa K, Okamoto-Matsuda K, Harada KH, Minata M, Hitomi T, Kobayashi H, Koizumi A., Free PMC Article | 03/26/2024 |
| The inhibition of YAP Signaling Prevents Chronic Biliary Fibrosis in the Abcb4[-/-] Model by Modulation of Hepatic Stellate Cell and Bile Duct Epithelium Cell Pathophysiology. | The inhibition of YAP Signaling Prevents Chronic Biliary Fibrosis in the Abcb4(-/-) Model by Modulation of Hepatic Stellate Cell and Bile Duct Epithelium Cell Pathophysiology.
Ye L, Ziesch A, Schneider JS, Ofner A, Nieß H, Denk G, Hohenester S, Mayr D, Mahajan UM, Munker S, Khaled NB, Wimmer R, Gerbes AL, Mayerle J, He Y, Geier A, Toni EN, Zhang C, Reiter FP., Free PMC Article | 01/26/2024 |
| Genetic variant c.711A>T in the hepatobiliary phospholipid transporter ABCB4 is associated with significant liver fibrosis. | Genetic variant c.711A>T in the hepatobiliary phospholipid transporter ABCB4 is associated with significant liver fibrosis.
Smyk W, Weber SN, Hall R, Gruenhage F, Lammert F, Krawczyk M. | 07/17/2021 |
| Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice. | Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice.
Gonzalez-Sanchez E, El Mourabit H, Jager M, Clavel M, Moog S, Vaquero J, Ledent T, Cadoret A, Gautheron J, Fouassier L, Wendum D, Chignard N, Housset C. | 07/3/2021 |
| The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma. | The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma.
Gamaev L, Mizrahi L, Friehmann T, Rosenberg N, Pappo O, Olam D, Zeira E, Bahar Halpern K, Caruso S, Zucman-Rossi J, Axelrod JH, Galun E, Goldenberg DS. | 04/17/2021 |
| Administration of Human MSC-Derived Extracellular Vesicles for the Treatment of Primary Sclerosing Cholangitis: Preclinical Data in MDR2 Knockout Mice. | Administration of Human MSC-Derived Extracellular Vesicles for the Treatment of Primary Sclerosing Cholangitis: Preclinical Data in MDR2 Knockout Mice.
Angioni R, Calì B, Vigneswara V, Crescenzi M, Merino A, Sánchez-Rodríguez R, Liboni C, Hoogduijn MJ, Newsome PN, Muraca M, Russo FP, Viola A., Free PMC Article | 03/6/2021 |
| Knockout of the Tachykinin Receptor 1 in the Mdr2(-/-) (Abcb4(-/-)) Mouse Model of Primary Sclerosing Cholangitis Reduces Biliary Damage and Liver Fibrosis. | Knockout of the Tachykinin Receptor 1 in the Mdr2(-/-) (Abcb4(-/-)) Mouse Model of Primary Sclerosing Cholangitis Reduces Biliary Damage and Liver Fibrosis.
Ceci L, Francis H, Zhou T, Giang T, Yang Z, Meng F, Wu N, Kennedy L, Kyritsi K, Meadows V, Wu C, Liangpunsakul S, Franchitto A, Sybenga A, Ekser B, Mancinelli R, Onori P, Gaudio E, Glaser S, Alpini G., Free PMC Article | 12/5/2020 |
| Cholangiocytes, but not hepatocytes, from stem cell factor (SCF) Mismatch Mdr2(-/-) mice have increased SCF expression and secretion. Inhibition of SCF in Mdr2(-/-) mice reduced (i) hepatic damage; (ii) mast cell migration; (iii) histamine and SCF serum levels. | Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage/senescence and liver fibrosis in Mdr2(-/-) mice.
Meadows V, Kennedy L, Hargrove L, Demieville J, Meng F, Virani S, Reinhart E, Kyritsi K, Invernizzi P, Yang Z, Wu N, Liangpunsakul S, Alpini G, Francis H., Free PMC Article | 05/30/2020 |
| Taurohyodeoxycholate strongly enhances biliary phosphatidylcholine (PC) secretion in Abcb4+/+ mice. Taurohyodeoxycholate has no effect on biliary PC secretion in Abcb4-/- mice. | Enhancing effect of taurohyodeoxycholate on ABCB4-mediated phospholipid efflux.
Ikeda Y, Morita SY, Hatano R, Tsuji T, Terada T. | 03/7/2020 |
| Thyroid hormone receptor beta1 stimulates ABCB4 to increase biliary phosphatidylcholine excretion | Thyroid hormone receptor β1 stimulates ABCB4 to increase biliary phosphatidylcholine excretion in mice.
Gautherot J, Claudel T, Cuperus F, Fuchs CD, Falguières T, Trauner M., Free PMC Article | 09/14/2019 |
| When looking at the gender-specific response to corticosterone treatment, male MDR2KO mice tended to have a more pronounced reversal of liver fibrosis than females treated with corticosterone | Glucocorticoids Cause Gender-Dependent Reversal of Hepatic Fibrosis in the MDR2-Knockout Mouse Model.
Petrescu AD, Grant S, Frampton G, Kain J, Hadidi K, Williams E, McMillin M, DeMorrow S., Free PMC Article | 07/14/2018 |
| reduced ABCB4 expression predisposes to extrahepatic biliary atresia | Hepatic MDR3 expression impacts lipid homeostasis and susceptibility to inflammatory bile duct obstruction in neonates.
Carey AN, Zhang W, Setchell KDR, Simmons JR, Shi T, Lages CS, Mullen M, Carroll K, Karns R, Bessho K, Sheridan R, Zhao X, Weber SN, Miethke AG., Free PMC Article | 06/23/2018 |
| Findings imply a close link between Mdr2 (-/-) -associated tumorigenesis and perturbation of these biological processes and suggest potential extrahepatic functions of Mdr2. | Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress.
Tebbi A, Levillayer F, Jouvion G, Fiette L, Soubigou G, Varet H, Boudjadja N, Cairo S, Hashimoto K, Suzuki AM, Carninci P, Carissimo A, di Bernardo D, Wei Y., Free PMC Article | 06/28/2016 |
| The antifibrotic effects of rapamycin, everolimus, captopril and irbesartan seen in other models of fibrosis were not replicated in the Mdr2(-/-) model of liver fibrosis. | Lack of efficacy of mTOR inhibitors and ACE pathway inhibitors as antifibrotic agents in evolving and established fibrosis in Mdr2⁻/⁻ mice.
Bridle KR, Sobbe AL, de Guzman CE, Santrampurwala N, Jaskowski LA, Clouston AD, Campbell CM, Nathan Subramaniam V, Crawford DH. | 12/19/2015 |
| A new Mdr2(-/-) mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer. | A new Mdr2(-/-) mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer.
Ikenaga N, Liu SB, Sverdlov DY, Yoshida S, Nasser I, Ke Q, Kang PM, Popov Y. | 09/26/2015 |
| Glyceryl trinitrate improves hepatocyte engraftment and correction of metabolic disease in mdr2 (-/-) mice. | Improvement of hepatocyte transplantation efficiency in the mdr2-/- mouse model by glyceryl trinitrate.
Boudechiche L, Tranchart H, Branchereau S, Davit-Spraul A, Laïnas P, Groyer-Picard MT, Weber A, Hadchouel M, Dagher I. | 02/21/2015 |
| nsulin-like growth factor 1 enhances bile-duct proliferation and fibrosis in Abcb4(-/-) mice. | Insulin-like growth factor 1 enhances bile-duct proliferation and fibrosis in Abcb4(-/-) mice.
Sokolović A, Rodriguez-Ortigosa CM, Bloemendaal LT, Oude Elferink RP, Prieto J, Bosma PJ. | 07/6/2013 |
| Data indicate that Abcb4-knockout mice displayed significantly (P<0.001) lower plasma glucose concentrations than corresponding wild-type controls. | The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis.
Hochrath K, Krawczyk M, Goebel R, Langhirt M, Rathkolb B, Micklich K, Rozman J, Horsch M, Beckers J, Klingenspor M, Fuchs H, Gailus-Durner V, Wolf E, Acalovschi M, Volmer DA, Hrabě de Angelis M, Lammert F. | 04/13/2013 |
| Mdr2(-/-)IKK2(Hep-KO) mice remarkably recapitulate chronic liver failure in humans and might be of special importance for the study of the mechanisms contributing to the pathogenesis of end-stage chronic liver disease. | Hepatocyte IKK2 protects Mdr2-/- mice from chronic liver failure.
Ehlken H, Kondylis V, Heinrichsdorff J, Ochoa-Callejero L, Roskams T, Pasparakis M., Free PMC Article | 02/18/2012 |
| Flippase ATP8B1 and the floppase ABCB4 have complementary functions in maintaining canalicular membrane integrity. | Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.
Groen A, Romero MR, Kunne C, Hoosdally SJ, Dixon PH, Wooding C, Williamson C, Seppen J, Van den Oever K, Mok KS, Paulusma CC, Linton KJ, Oude Elferink RP. | 01/21/2012 |
| Downregulation of JunD and cyclin D1 expression in myofibroblasts may be important regarding the mechanism of action of MTA in Mdr2-/- mice | Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice.
Latasa MU, Gil-Puig C, Fernández-Barrena MG, Rodríguez-Ortigosa CM, Banales JM, Urtasun R, Goñi S, Méndez M, Arcelus S, Juanarena N, Recio JA, Lotersztajn S, Prieto J, Berasain C, Corrales FJ, Lecanda J, Avila MA., Free PMC Article | 07/9/2011 |
| E4BP4 is a negative transcription factor for circadian Mdr2 mRNA expression | Identification of negative transcriptional factor E4BP4-binding site in the mouse circadian-regulated gene Mdr2.
Kotaka M, Onishi Y, Ohno T, Akaike T, Ishida N. | 01/21/2010 |
| Multiple genes regulating inflammation and fibrosis not previously linked to Abcb4 deficient cholangitis are identified as being differentially transcribed in Abcb4 deficient livers, where they contribute to the pathogenesis of liver tissue pathology. | Multiple inflammatory-, tissue remodelling- and fibrosis genes are differentially transcribed in the livers of Abcb4 (-/ - ) mice harbouring chronic cholangitis.
Nakken KE, Nygård S, Haaland T, Berge KE, Arnkvaern K, Ødegaard A, Labori KJ, Raeder MG. | 01/21/2010 |
| Mdr2 seems not to be involved in the protection of the fetus from teratogens. | The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting.
Rawles LA, Acuna D, Erickson RP. | 01/21/2010 |