| PI3KCIIalpha-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in Mice. | PI3KCIIα-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in Mice.
Nasr M, Fay A, Lupieri A, Malet N, Darmon A, Zahreddine R, Swiader A, Wahart A, Viaud J, Nègre-Salvayre A, Hirsch E, Monteyne D, Perez-Morgà D, Dupont N, Codogno P, Ramel D, Morel E, Laffargue M, Gayral S. | 06/28/2024 |
| Discoidin domain receptor 2 signaling through PIK3C2alpha in fibroblasts promotes lung fibrosis. | Discoidin domain receptor 2 signaling through PIK3C2α in fibroblasts promotes lung fibrosis.
Ling S, Kwak D, Takuwa Y, Ge C, Franceschi R, Kim KK., | 03/6/2024 |
| PI3KC2alpha inhibition is antithrombotic in blood from hypercholesterolemic mice. | PI3KC2α inhibition is antithrombotic in blood from hypercholesterolemic mice.
Setiabakti NM, Tarlac V, Larsson P, Hamilton JR. | 01/6/2024 |
| PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. | PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo WT, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM Jr, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E., Free PMC Article | 12/25/2021 |
| Class II phosphatidylinositol 3-kinase alpha and beta isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice. | Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice.
Islam S, Yoshioka K, Aki S, Ishimaru K, Yamada H, Takuwa N, Takuwa Y., Free PMC Article | 02/20/2021 |
| Cbl-PI3K interaction regulates Cathepsin K secretion in osteoclasts. | Cbl-PI3K interaction regulates Cathepsin K secretion in osteoclasts.
Yu J, Adapala NS, Doherty L, Sanjay A., Free PMC Article | 09/19/2020 |
| Pik3c2a regulates shear stress-associated autophagy and cell size regulation.PI3KC2alpha, required for ciliogenesis and primary cilium functions, promotes the synthesis of a local pool of phosphatidylinositol-3-phosphate upon shear stress. | PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress.
Boukhalfa A, Nascimbeni AC, Ramel D, Dupont N, Hirsch E, Gayral S, Laffargue M, Codogno P, Morel E., Free PMC Article | 04/18/2020 |
| Both PI3K-C2alpha and PI3K-C2beta are required for normal uterine smooth muscle contraction and parturition mainly through their involvement in Rhoa activation. | Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice.
Sarker MAK, Aki S, Yoshioka K, Kuno K, Okamoto Y, Ishimaru K, Takuwa N, Takuwa Y. | 02/1/2020 |
| Studies indicate that the structural changes in PI3KC2alpha-deficient platelets are limited to the membrane, occur without major changes in lipid composition, and selectively impair cell function during thrombus formation. Functionally, PI3KC2alpha-deficient platelets exhibit impaired thrombosis specifically under conditions involving membrane tethering. | The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition.
Selvadurai MV, Brazilek RJ, Moon MJ, Rinckel JY, Eckly A, Gachet C, Meikle PJ, Nandurkar HH, Nesbitt WS, Hamilton JR. | 07/13/2019 |
| This study adds to this divergence by indicating a nonredundant role for PI3KC2alpha, with no role for PI3KC2beta, in regulating platelet OCS structure and overall platelet-dependent thrombus stability. | Combined deficiency of PI3KC2α and PI3KC2β reveals a nonredundant role for PI3KC2α in regulating mouse platelet structure and thrombus stability.
Petitjean C, Setiabakti NM, Mountford JK, Arthur JF, Ellis S, Hamilton JR. | 03/11/2017 |
| PI3KC2a knockdown results in rerouting of insulin signaling and pancreatic beta cell proliferation. | PI3K-C2α Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation.
Leibiger B, Moede T, Paschen M, Yunn NO, Lim JH, Ryu SH, Pereira T, Berggren PO, Leibiger IB. | 07/16/2016 |
| Heterozygous PI3K-C2-alpha inactivation in platelets led to reduction in phosphatidylinositol 3-monophosphate and a mislocalization of several membrane skeleton proteins known to control the interactions between the plasma membrane and cytoskeleton. | Essential role of class II PI3K-C2α in platelet membrane morphology.
Valet C, Chicanne G, Severac C, Chaussade C, Whitehead MA, Cabou C, Gratacap MP, Gaits-Iacovoni F, Vanhaesebroeck B, Payrastre B, Severin S. | 11/28/2015 |
| Data (including data from knockout mice) suggest that Pi3kc2a participates in tumor angiogenesis. [REVIEW] | New insight into the intracellular roles of class II phosphoinositide 3-kinases.
Maffucci T, Falasca M. | 06/6/2015 |
| Our studies indicate that while Vps34 is the main PI3P source during autophagy, class II PI3Ks also significantly contribute to PI3P generation and regulate AP biogenesis. | Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.
Devereaux K, Dall'Armi C, Alcazar-Roman A, Ogasawara Y, Zhou X, Wang F, Yamamoto A, De Camilli P, Di Paolo G., Free PMC Article | 08/9/2014 |
| PI3K-C2alpha has a crucial role in vascular formation and barrier integrity | Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.
Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, Okamoto Y, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz RJ, Okamoto H, Sasaki T, Matsui O, Asano M, Adams RH, Takakura N, Takuwa Y. | 01/12/2013 |
| PI3KC2alpha-deficient mice developed chronic renal failure and exhibited a range of kidney lesions, including glomerular crescent formation and renal tubule defects in early disease, which progressed to diffuse mesangial sclerosis. | Requirement for class II phosphoinositide 3-kinase C2alpha in maintenance of glomerular structure and function.
Harris DP, Vogel P, Wims M, Moberg K, Humphries J, Jhaver KG, DaCosta CM, Shadoan MK, Xu N, Hansen GM, Balakrishnan S, Domin J, Powell DR, Oravecz T., Free PMC Article | 01/29/2011 |
| phosphoinositide 3-kinase C2alpha has a role in insulin signaling | The role of phosphoinositide 3-kinase C2alpha in insulin signaling.
Falasca M, Hughes WE, Dominguez V, Sala G, Fostira F, Fang MQ, Cazzolli R, Shepherd PR, James DE, Maffucci T. | 01/21/2010 |