| PIKfyve, expressed by CD11c-positive cells, controls tumor immunity. | PIKfyve, expressed by CD11c-positive cells, controls tumor immunity.
Choi JE, Qiao Y, Kryczek I, Yu J, Gurkan J, Bao Y, Gondal M, Tien JC, Maj T, Yazdani S, Parolia A, Xia H, Zhou J, Wei S, Grove S, Vatan L, Lin H, Li G, Zheng Y, Zhang Y, Cao X, Su F, Wang R, He T, Cieslik M, Green MD, Zou W, Chinnaiyan AM., Free PMC Article | 07/10/2024 |
| Intermittent inhibition of FYVE finger-containing phosphoinositide kinase induces melanosome degradation in B16F10 melanoma cells. | Intermittent inhibition of FYVE finger-containing phosphoinositide kinase induces melanosome degradation in B16F10 melanoma cells.
Kawaguchi K, Watanabe M, Furukawa S, Koga K, Kanamori H, Ikemoto MJ, Takashima S, Maeda M, Oh-Hashi K, Hirata Y, Furuta K, Takemori H. | 06/28/2023 |
| Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity. | Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity.
Saffi GT, Wang CA, Mangialardi EM, Vacher J, Botelho RJ, Salmena L., Free PMC Article | 09/17/2022 |
| PIKfyve-Dependent Phosphoinositide Dynamics in Megakaryocyte/Platelet Granule Integrity and Platelet Functions. | PIKfyve-Dependent Phosphoinositide Dynamics in Megakaryocyte/Platelet Granule Integrity and Platelet Functions.
Caux M, Mansour R, Xuereb JM, Chicanne G, Viaud J, Vauclard A, Boal F, Payrastre B, Tronchère H, Severin S. | 08/6/2022 |
| Inhibition of PIKfyve Ameliorates the Proliferation and Migration of Vascular Smooth Muscle Cells and Vascular Intima Hyperplasia By Reducing mTORC1 Activity. | Inhibition of PIKfyve Ameliorates the Proliferation and Migration of Vascular Smooth Muscle Cells and Vascular Intima Hyperplasia By Reducing mTORC1 Activity.
Gu M, Wang Z, Feng F, Yang Y, Sun X, Yang D., Free PMC Article | 05/14/2022 |
| Snx10 and PIKfyve are required for lysosome formation in osteoclasts. | Snx10 and PIKfyve are required for lysosome formation in osteoclasts.
Sultana F, Morse LR, Picotto G, Liu W, Jha PK, Odgren PR, Battaglino RA. | 07/10/2021 |
| Study shows that PIKfyve modulation of lysosomal degradative activity and protein expression is essential to maintain lysosomal homeostasis in macrophages. | PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice.
Min SH, Suzuki A, Weaver L, Guzman J, Chung Y, Jin H, Gonzalez F, Trasorras C, Zhao L, Spruce LA, Seeholzer SH, Behrens EM, Abrams CS., Free PMC Article | 02/29/2020 |
| PIKfyve inhibition leads to impaired degradative capacity, ion dysregulation, abated autophagic flux and a massive enlargement of lysosomes. | Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence.
Choy CH, Saffi G, Gray MA, Wallace C, Dayam RM, Ou ZA, Lenk G, Puertollano R, Watkins SC, Botelho RJ., Free PMC Article | 11/2/2019 |
| enlarged vacuole formation in PIKfyve-deficient cells was not rescued by Ca2+ or over expression of TRPML1. It is likely that the acidification and vacuolation arrest is bifurcating downstream of PIKfyve | PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel.
Isobe Y, Nigorikawa K, Tsurumi G, Takemasu S, Takasuga S, Kofuji S, Hazeki K. | 01/26/2019 |
| these studies identify a novel role for PIKfyve in controlling the delivery of proteins from the endosomal compartment to the melanosome, a role that is distinct from the role of PIKfyve in the reformation of lysosomes from endolysosomes. | PIKfyve regulates melanosome biogenesis.
Liggins MC, Flesher JL, Jahid S, Vasudeva P, Eby V, Takasuga S, Sasaki J, Sasaki T, Boissy RE, Ganesan AK., Free PMC Article | 06/30/2018 |
| The authors provide evidence that inactivation of PIKfyve by the selective inhibitor STA suppresses excessive mitochondrial reactive oxygen species production and apoptosis through a SIRT3-dependent pathway in cardiomyoblasts. | Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice.
Tronchere H, Cinato M, Timotin A, Guitou L, Villedieu C, Thibault H, Baetz D, Payrastre B, Valet P, Parini A, Kunduzova O, Boal F., Free PMC Article | 02/24/2018 |
| this study shows that PIKfyve coordinates the neutrophil immune response through the activation of the Rac GTPase | The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase.
Dayam RM, Sun CX, Choy CH, Mancuso G, Glogauer M, Botelho RJ. | 10/14/2017 |
| Thus, PIKfyve plays a role in preventing excessive lung inflammation through regulating alveolar macrophage function. | Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.
Kawasaki T, Ito K, Miyata H, Akira S, Kawai T., Free PMC Article | 07/22/2017 |
| A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity. | A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity.
Guscott B, Balklava Z, Safrany ST, Wassmer T., Free PMC Article | 12/17/2016 |
| adipose tissue Pikfyve plays a key role in the mechanisms regulating glucose homeostasis and the PIKfyve pathway is critical in mammary epithelial differentiation during pregnancy and lactogenesis downstream of prolactin receptor signaling. | Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development.
Ikonomov OC, Sbrissa D, Delvecchio K, Rillema JA, Shisheva A., Free PMC Article | 10/8/2016 |
| AP-3 recruitment to TLR9 endosomes was impaired by PIKfyve inhibition. | Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activity.
Hayashi K, Sasai M, Iwasaki A., Free PMC Article | 05/21/2016 |
| PIKfyve mediates vesicle motility through the regulation of vesicle integrity in neurons. | PIKfyve mediates the motility of late endosomes and lysosomes in neuronal dendrites.
Tsuruta F, Dolmetsch RE. | 01/2/2016 |
| Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice. | Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.
Min SH, Suzuki A, Stalker TJ, Zhao L, Wang Y, McKennan C, Riese MJ, Guzman JF, Zhang S, Lian L, Joshi R, Meng R, Seeholzer SH, Choi JK, Koretzky G, Marks MS, Abrams CS., Free PMC Article | 10/31/2015 |
| Vps34 is a main phosphatidylinositol 3-phosphate source for constitutive PIKfyve functionality. | Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis.
Ikonomov OC, Sbrissa D, Venkatareddy M, Tisdale E, Garg P, Shisheva A., Free PMC Article | 09/5/2015 |
| Daam2-PIP5K function, application of which stimulates remyelination after white matter injury | Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS.
Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SP, Deneen B., Free PMC Article | 05/23/2015 |
| Data indicate that pharmacological or genetic inactivation of PIKfyve rapidly induces expression of the transcription repressor ATF3, which is necessary and sufficient for suppression of type I IFN expression. | PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3.
Cai X, Xu Y, Kim YM, Loureiro J, Huang Q. | 06/14/2014 |
| PIP5Kbeta negatively regulates axon elongation and growth cone size and is involved in the cellular signaling pathway for Sema3A-triggered repulsion in DRG neurons. | Phosphatidylinositol 4-phosphate 5-kinase β regulates growth cone morphology and semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons.
Yamazaki M, Yamauchi Y, Goshima Y, Kanaho Y. | 01/18/2014 |
| PIKfyve is essential for systemic glucose homeostasis and insulin-regulated glucose uptake/GLUT4 translocation in skeletal muscle. | Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching.
Ikonomov OC, Sbrissa D, Delvecchio K, Feng HZ, Cartee GD, Jin JP, Shisheva A., Free PMC Article | 09/14/2013 |
| Data indicate that type III phosphatidylinositol phosphate kinase (PIPKIII) is essential for embryonic development. | Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine.
Takasuga S, Horie Y, Sasaki J, Sun-Wada GH, Kawamura N, Iizuka R, Mizuno K, Eguchi S, Kofuji S, Kimura H, Yamazaki M, Horie C, Odanaga E, Sato Y, Chida S, Kontani K, Harada A, Katada T, Suzuki A, Wada Y, Ohnishi H, Sasaki T., Free PMC Article | 05/4/2013 |
| PIP5Kalpha promotes TLR4-associated microglial inflammation by mediating PIP(2)-dependent recruitment of TIRAP to the plasma membrane | Phosphatidylinositol 4-phosphate 5-kinase α facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location.
Nguyen TT, Kim YM, Kim TD, Le OT, Kim JJ, Kang HC, Hasegawa H, Kanaho Y, Jou I, Lee SY., Free PMC Article | 04/27/2013 |