| The Crucial Roles of Pitx3 in Midbrain Dopaminergic Neuron Development and Parkinson's Disease-Associated Neurodegeneration. | The Crucial Roles of Pitx3 in Midbrain Dopaminergic Neuron Development and Parkinson's Disease-Associated Neurodegeneration.
Wang X, Chen X, Liu G, Cai H, Le W., Free PMC Article | 05/31/2023 |
| Activation of CB2R with AM1241 ameliorates neurodegeneration via the Xist/miR-133b-3p/Pitx3 axis. | Activation of CB2R with AM1241 ameliorates neurodegeneration via the Xist/miR-133b-3p/Pitx3 axis.
He X, Yang L, Huang R, Lin L, Shen Y, Cheng L, Jin L, Wang S, Zhu R. | 03/13/2021 |
| Hypomorphic Expression of Pitx3 Disrupts Circadian Clocks and Prevents Metabolic Entrainment of Energy Expenditure. | Hypomorphic Expression of Pitx3 Disrupts Circadian Clocks and Prevents Metabolic Entrainment of Energy Expenditure.
Del Río-Martín A, Pérez-Taboada I, Fernández-Pérez A, Moratalla R, de la Villa P, Vallejo M. | 09/26/2020 |
| Using Pitx2/3 single and double mutant mice that provide genetic models of deregulated redox states, we demonstrate that moderate overproduction of ROS results in premature differentiation of satellite cells while high levels lead to their senescence and regenerative failure | The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration.
L'honoré A, Commère PH, Negroni E, Pallafacchina G, Friguet B, Drouin J, Buckingham M, Montarras D., Free PMC Article | 01/26/2019 |
| that Pitx3 is co-recruited to regions that foster the formation of GATA-bHLH-BRN complexes, which usually involve Lmo co-regulatory proteins | Specificity of Pitx3-Dependent Gene Regulatory Networks in Subsets of Midbrain Dopamine Neurons.
Bifsha P, Balsalobre A, Drouin J. | 05/12/2018 |
| in absence of En1 and Pitx3, only a limited number of Mesodiencephalic dopaminergic neurons are present in mouse embryo. | Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool.
Kouwenhoven WM, von Oerthel L, Smidt MP., Free PMC Article | 10/14/2017 |
| Pitx3 is specifically required for DA-related function and, if impaired, Pitx3 could contribute during the pathogenesis of Parkinson's disease. | Pitx3 deficiency produces decreased dopamine signaling and induces motor deficits in Pitx3(-/-) mice.
Le W, Zhang L, Xie W, Li S, Dani JA., Free PMC Article | 08/20/2016 |
| the sonic hedgehog signaling pathway is both necessary and sufficient for the induction of ectopic PITX3 expression in chick mesencephalon downstream of WNT9A-induced LMX1a transcription. | Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development.
Klafke R, Prem Anand AA, Wurst W, Prakash N, Wizenmann A. | 07/16/2016 |
| microphthalmos/aphakia inPITX3 nonsense mutant is caused by the expression of truncated PITX3, resulting in the abnormal expression of downstream targets and lens fiber proteins. | Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice.
Wada K, Matsushima Y, Tada T, Hasegawa S, Obara Y, Yoshizawa Y, Takahashi G, Hiai H, Shimanuki M, Suzuki S, Saitou J, Yamamoto N, Ichikawa M, Watanabe K, Kikkawa Y., Free PMC Article | 12/26/2015 |
| Pitx3 binds to an evolutionary conserved bicoid-binding site on the 5'-upstream region of Foxe3. Pitx3 binding to 5'-upstream region of Foxe3 increased transcriptional activity significantly in a cell-based reporter assay. | Pitx3 directly regulates Foxe3 during early lens development.
Ahmad N, Aslam M, Muenster D, Horsch M, Khan MA, Carlsson P, Beckers J, Graw J. | 09/6/2014 |
| During fetal myogenesis, Pitx2/3 control this redox state through the regulation of Nrf1 and of antioxidant pathways. | Redox regulation by Pitx2 and Pitx3 is critical for fetal myogenesis.
L'honoré A, Commère PH, Ouimette JF, Montarras D, Drouin J, Buckingham M. | 08/9/2014 |
| Pitx3 overexpressing mouse significantly affects the gene expression of midbrain dopamine neurons. Motor coordination and locomotion activities are significantly affected in mice overexpressing Pitx3 mice. | Impaired motor coordination in Pitx3 overexpression mice.
Kim H, Quan X, Seong Y, Kim J. | 06/28/2014 |
| Primary fetal neurobehavioral deficit of the Pitx3 mutation is akinesia related to nigrostriatal damage. | Prenatal ontogeny of the dopamine-dependent neurobehavioral phenotype in Pitx3-deficient mice.
Kleven GA, Joshi P, Voogd M, Ronca AE., Free PMC Article | 12/7/2013 |
| Two crucial mediators of mesodiencephalic dopaminergic neuronal development, En1 and Pitx3, interact in dopaminergic subset specification. | Specification of dopaminergic subsets involves interplay of En1 and Pitx3.
Veenvliet JV, Dos Santos MT, Kouwenhoven WM, von Oerthel L, Lim JL, van der Linden AJ, Koerkamp MJ, Holstege FC, Smidt MP. | 10/19/2013 |
| a novel link between Pitx3 function and the selective pattern of midbrain dopaminergic neurons cell loss observed in Parkinson's disease. | The transcription factor Pitx3 is expressed selectively in midbrain dopaminergic neurons susceptible to neurodegenerative stress.
Luk KC, Rymar VV, van den Munckhof P, Nicolau S, Steriade C, Bifsha P, Drouin J, Sadikot AF. | 08/10/2013 |
| Reduced Th expression was associated with loss of Pitx3. | Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf.
Clark J, Silvaggi JM, Kiselak T, Zheng K, Clore EL, Dai Y, Bass CE, Simon DK., Free PMC Article | 07/27/2013 |
| Pitx3 mutant mice are a convenient and valid mouse model to study the compensatory 5-HT upregulation | Serotonin hyperinnervation and upregulated 5-HT2A receptor expression and motor-stimulating function in nigrostriatal dopamine-deficient Pitx3 mutant mice.
Li L, Qiu G, Ding S, Zhou FM., Free PMC Article | 06/1/2013 |
| The Pitx3 gene is well known for its specific expression in mdDA neurons and is present at the onset of terminal differentiation. | Spatial and temporal lineage analysis of a Pitx3-driven Cre-recombinase knock-in mouse model.
Smidt MP, von Oerthel L, Hoekstra EJ, Schellevis RD, Hoekman MF., Free PMC Article | 02/23/2013 |
| There is a direct interaction between Nurr1 and the Pitx3 gene promoter. | Direct regulation of Pitx3 expression by Nurr1 in culture and in developing mouse midbrain.
Volpicelli F, De Gregorio R, Pulcrano S, Perrone-Capano C, di Porzio U, Bellenchi GC., Free PMC Article | 06/30/2012 |
| Pitx3 acts on multiple levels in the molecular subset-specification of mdDA neurons. | Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons.
Jacobs FM, Veenvliet JV, Almirza WH, Hoekstra EJ, von Oerthel L, van der Linden AJ, Neijts R, Koerkamp MG, van Leenen D, Holstege FC, Burbach JP, Smidt MP. | 01/7/2012 |
| Pitx3-deficient aphakia mice display unique behavioral responses to psychostimulant and antipsychotic drugs | Pitx3-deficient aphakia mice display unique behavioral responses to psychostimulant and antipsychotic drugs.
Ardayfio PA, Leung A, Park J, Hwang DY, Moran-Gates T, Choi YK, Carlezon WA Jr, Tarazi FI, Kim KS., Free PMC Article | 05/10/2010 |
| The frame-shift mutation (Pitx eyl ) affects the C-terminal part of the transcription factor Pitx3 and causes alterations in the eye and brain. | Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice.
Rosemann M, Ivashkevich A, Favor J, Dalke C, Hölter SM, Becker L, Rácz I, Bolle I, Klempt M, Rathkolb B, Kalaydjiev S, Adler T, Aguilar A, Hans W, Horsch M, Rozman J, Calzada-Wack J, Kunder S, Naton B, Gailus-Durner V, Fuchs H, Schulz H, Beckers J, Busch DH, Burbach JP, Smidt MP, Quintanilla-Martinez L, Esposito I, Klopstock T, Klingenspor M, Ollert M, Wolf E, Wurst W, Zimmer A, de Angelis MH, Atkinson M, Heinzmann U, Graw J. | 04/19/2010 |
| Data found that reduced expression of Pitx3 leads to changes in the proliferation, differentiation and survival of lens cells. | Pitx3 controls multiple aspects of lens development.
Medina-Martinez O, Shah R, Jamrich M., Free PMC Article | 01/21/2010 |
| Our study, using Pitx3-deficient embryonic stem cells in an in-vitro differentiation culture system, allowed us to assess the role of Pitx3 in the specification and final maturation of dopaminergic neurons. | In-vitro analysis of Pitx3 in mesodiencephalic dopaminergic neuron maturation.
Papanikolaou T, Amano T, Lennington J, Sink K, Farrar AM, Salamone J, Yang X, Conover JC. | 01/21/2010 |
| Pitx3 is essential to maintain lens epithelial phenotype and prevent inappropriate fibre cell differentiation during lens development | Homeodomain protein Pitx3 maintains the mitotic activity of lens epithelial cells.
Ho HY, Chang KH, Nichols J, Li M. | 01/21/2010 |