| cPKCgamma Inhibits Caspase-9-Initiated Neuronal Apoptosis in an Ischemia Reperfusion Model In Vitro Through p38 MAPK-p90RSK-Bad Pathway. | cPKCγ Inhibits Caspase-9-Initiated Neuronal Apoptosis in an Ischemia Reperfusion Model In Vitro Through p38 MAPK-p90RSK-Bad Pathway.
Wei HP, Peng ZF, Shao KM, Zhang PH, Chen L, Hu JA, Chai H, Liu JM. | 02/11/2023 |
| Protein kinase Cgamma in cerebellar Purkinje cells regulates Ca(2+)-activated large-conductance K(+) channels and motor coordination. | Protein kinase Cγ in cerebellar Purkinje cells regulates Ca(2+)-activated large-conductance K(+) channels and motor coordination.
Watanave M, Takahashi N, Hosoi N, Konno A, Yamamoto H, Yasui H, Kawachi M, Horii T, Matsuzaki Y, Hatada I, Hirai H., Free PMC Article | 03/12/2022 |
| Protein Kinase C-Gamma Knockout Mice Show Impaired Hippocampal Short-Term Memory While Preserved Long-Term Memory. | Protein Kinase C-Gamma Knockout Mice Show Impaired Hippocampal Short-Term Memory While Preserved Long-Term Memory.
Gomis-González M, Galera-López L, Ten-Blanco M, Busquets-Garcia A, Cox T, Maldonado R, Ozaita A. | 09/4/2021 |
| A New Mouse Model Related to SCA14 Carrying a Pseudosubstrate Domain Mutation in PKCgamma Shows Perturbed Purkinje Cell Maturation and Ataxic Motor Behavior. | A New Mouse Model Related to SCA14 Carrying a Pseudosubstrate Domain Mutation in PKCγ Shows Perturbed Purkinje Cell Maturation and Ataxic Motor Behavior.
Shimobayashi E, Kapfhammer JP., Free PMC Article | 08/14/2021 |
| PKCgamma-Mediated Phosphorylation of CRMP2 Regulates Dendritic Outgrowth in Cerebellar Purkinje Cells. | PKCγ-Mediated Phosphorylation of CRMP2 Regulates Dendritic Outgrowth in Cerebellar Purkinje Cells.
Winkler SC, Shimobayashi E, Kapfhammer JP., Free PMC Article | 07/3/2021 |
| Precise Regulation of the Basal PKCgamma Activity by DGKgamma Is Crucial for Motor Coordination. | Precise Regulation of the Basal PKCγ Activity by DGKγ Is Crucial for Motor Coordination.
Tsumagari R, Maruo K, Kakizawa S, Ueda S, Yamanoue M, Saito H, Suzuki N, Shirai Y., Free PMC Article | 03/6/2021 |
| Proteomic analysis of synaptic protein turnover in the anterior cingulate cortex after nerve injury. | Proteomic analysis of synaptic protein turnover in the anterior cingulate cortex after nerve injury.
Ko HG, Park DI, Lee JH, Turck CW, Kaang BK., Free PMC Article | 02/13/2021 |
| cPKCgamma knockout significantly increased the infarct volume of mice after experimental ischemic stroke. cPKCgamma knockout also aggravated the oxygen-glucose deprivation-induced cell death and morphological damage of neurites in culture, while cPKCgamma restoration could alleviate the ischemic injury. Phosphorylation levels of synapsin Ia/b Ser549 and 553 could be modulated by cPKCgamma following ischemia. | cPKCγ alleviates ischemic injury through modulating synapsin Ia/b phosphorylation in neurons of mice.
Zhang N, Zhu H, Han S, Sui L, Li J. | 07/27/2019 |
| PRKCG is a protective modifier of Purkinje neuron degeneration in cerebellar ataxia mouse models. | Protein kinase C activity is a protective modifier of Purkinje neuron degeneration in cerebellar ataxia.
Chopra R, Wasserman AH, Pulst SM, De Zeeuw CI, Shakkottai VG., Free PMC Article | 02/9/2019 |
| our results suggest that the decrease in the activity of cPKCbetaII and cPKCgamma, especially cPKCgamma, may play key roles in the pathogenesis of diabetic encephalopathy. | Identification of Protein Kinase C Isoforms Involved in Type 1 Diabetic Encephalopathy in Mice.
Zheng J, Wang Y, Han S, Luo Y, Sun X, Zhu N, Zhao L, Li J., Free PMC Article | 10/6/2018 |
| cPKC&-gamma modulated sequential reactivation of mTOR inhibited autophagic flux in neurons exposed to OGD/R, which may provide endogenous interventional strategies for stroke, especially ischemia/reperfusion injury | cPKCγ-Modulated Sequential Reactivation of mTOR Inhibited Autophagic Flux in Neurons Exposed to Oxygen Glucose Deprivation/Reperfusion.
Hua R, Han S, Zhang N, Dai Q, Liu T, Li J., Free PMC Article | 09/22/2018 |
| PKCgamma-mediated down-regulation of UCHL1 alleviates ischemic neuronal injuries by decreasing autophagy via ERK-mTOR pathway. | cPKCγ-mediated down-regulation of UCHL1 alleviates ischaemic neuronal injuries by decreasing autophagy via ERK-mTOR pathway.
Zhang D, Han S, Wang S, Luo Y, Zhao L, Li J., Free PMC Article | 07/21/2018 |
| SUMOylation of EphB1 repressed activation of its downstream signaling molecule PKC-gamma, and consequently inhibited neuroblastoma tumorigenesis. | Sumoylation of EphB1 Suppresses Neuroblastoma Tumorigenesis via Inhibiting PKCγ Activation.
Chen Q, Deng R, Zhao X, Yuan H, Zhang H, Dou J, Chen R, Jin H, Wang Y, Huang J, Yu J. | 06/23/2018 |
| CA8 is a novel important regulator of Purkinje cell dendritic development and that its expression is controlled by PKCgamma activity. | Carbonic Anhydrase 8 Expression in Purkinje Cells Is Controlled by PKCγ Activity and Regulates Purkinje Cell Dendritic Growth.
Shimobayashi E, Wagner W, Kapfhammer JP. | 01/27/2018 |
| These results suggested that cPKCgamma-modulated neuron-specific autophagy improves the neurological outcome of mice following ischemic stroke through the Akt-mTOR pathway, providing a potential therapeutic target for ischemic stroke. | cPKCγ-Modulated Autophagy in Neurons Alleviates Ischemic Injury in Brain of Mice with Ischemic Stroke Through Akt-mTOR Pathway.
Wei H, Li Y, Han S, Liu S, Zhang N, Zhao L, Li S, Li J. | 09/30/2017 |
| Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck-dependent activation of PKCdelta, which stimulates PKCgamma, resulting in translocation of phosphorylated p47(phox). | LysoPCs induce Hck- and PKCδ-mediated activation of PKCγ causing p47phox phosphorylation and membrane translocation in neutrophils.
Kelher MR, McLaughlin NJ, Banerjee A, Elzi DJ, Gamboni F, Khan SY, Meng X, Mitra S, Silliman CC., Free PMC Article | 09/2/2017 |
| Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma but decreased that of GABABR1 and GABABR2 at both protein and mRNA levels in the CNC | Puerarin alleviates noise-induced hearing loss via affecting PKCγ and GABAB receptor expression.
Qu J, Liao YH, Kou ZZ, Wei YY, Huang J, Chen J, Yanagawa Y, Wu SX, Shi M, Li YQ. | 08/8/2015 |
| PRKCgamma is critical for the localization of slit diaphragm components in the mouse kidney. | aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface.
Satoh D, Hirose T, Harita Y, Daimon C, Harada T, Kurihara H, Yamashita A, Ohno S., Free PMC Article | 04/4/2015 |
| Therefore, we propose that PKCgamma positively modulates dopamine release through beta2PIX phosphorylation. | The role of Pak-interacting exchange factor-β phosphorylation at serines 340 and 583 by PKCγ in dopamine release.
Shirafuji T, Ueyama T, Yoshino K, Takahashi H, Adachi N, Ago Y, Koda K, Nashida T, Hiramatsu N, Matsuda T, Toda T, Sakai N, Saito N., Free PMC Article | 09/13/2014 |
| These findings indicate that the identity of the calcium-dependent PKCgamma that mediates PTP controls the mechanism and functional consequences of Posttetanic potentiation. | Calcium-dependent PKC isoforms have specialized roles in short-term synaptic plasticity.
Chu Y, Fioravante D, Leitges M, Regehr WG., Free PMC Article | 07/19/2014 |
| This study provided new evidence to support the possibility of the involvement of PKC-gamma in the actions of volatile anesthetics in mice brain. | Hypnotic effect of volatile anesthetics is mediated by PKC-γ dynamics.
Takeda A, Okita A, Kaneko K, Nagura T, Iwase N, Sekine S, Kakinuma T, Noguchi M, Hatakeyama K. | 08/31/2013 |
| demonstrate a role for the gamma isotype of protein kinase C (PKCgamma) in food-mediated entrainment of behavior and the molecular clock | PKCγ participates in food entrainment by regulating BMAL1.
Zhang L, Abraham D, Lin ST, Oster H, Eichele G, Fu YH, Ptáček LJ., Free PMC Article | 03/2/2013 |
| transient receptor potential 3 which is also needed for mGluR1-dependent slow excitatory postsynaptic potentials and motor coordination and associates with PKCgamma | Glutamate receptor δ2 associates with metabotropic glutamate receptor 1 (mGluR1), protein kinase Cγ, and canonical transient receptor potential 3 and regulates mGluR1-mediated synaptic transmission in cerebellar Purkinje neurons.
Kato AS, Knierman MD, Siuda ER, Isaac JT, Nisenbaum ES, Bredt DS., Free PMC Article | 01/5/2013 |
| Membrane residence time of PKCalpha after depolarization-induced translocation is significantly decreased when it is present with the mutant PKCgamma construct of spinocerebellar ataxia type 14. | Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.
Shuvaev AN, Horiuchi H, Seki T, Goenawan H, Irie T, Iizuka A, Sakai N, Hirai H., Free PMC Article | 11/19/2011 |
| cPLA(2)-dependent AA release is required for VEGF-induced Src-PLD1-PKCgamma-mediated pathological retinal angiogenesis | Activation of cytosolic phospholipase A2 downstream of the Src-phospholipase D1 (PLD1)-protein kinase C γ (PKCγ) signaling axis is required for hypoxia-induced pathological retinal angiogenesis.
Zhang Q, Wang D, Singh NK, Kundumani-Sridharan V, Gadiparthi L, Rao ChM, Rao GN., Free PMC Article | 09/3/2011 |