| Enhanced SREBP2-driven cholesterol biosynthesis by PKClambda/iota deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. | Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.
Muta Y, Linares JF, Martinez-Ordoñez A, Duran A, Cid-Diaz T, Kinoshita H, Zhang X, Han Q, Nakanishi Y, Nakanishi N, Cordes T, Arora GK, Ruiz-Martinez M, Reina-Campos M, Kasashima H, Yashiro M, Maeda K, Albaladejo-Gonzalez A, Torres-Moreno D, García-Solano J, Conesa-Zamora P, Inghirami G, Metallo CM, Osborne TF, Diaz-Meco MT, Moscat J., Free PMC Article | 12/20/2023 |
| Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model. | Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model.
Weatherly SM, Collin GB, Charette JR, Stone L, Damkham N, Hyde LF, Peterson JG, Hicks W, Carter GW, Naggert JK, Krebs MP, Nishina PM., Free PMC Article | 07/2/2022 |
| Deficiency of PKClambda/iota alleviates the liver pathologic impairment of Schistosoma japonicum infection by thwarting Th2 response. | Deficiency of PKCλ/ι alleviates the liver pathologic impairment of Schistosoma japonicum infection by thwarting Th2 response.
Mei C, Yang Y, Dong P, Song L, Zhou Y, Xu Y, Yu C., Free PMC Article | 05/21/2022 |
| Atypical protein kinase C iota (PKClambda/iota) ensures mammalian development by establishing the maternal-fetal exchange interface. | Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal-fetal exchange interface.
Bhattacharya B, Home P, Ganguly A, Ray S, Ghosh A, Islam MR, French V, Marsh C, Gunewardena S, Okae H, Arima T, Paul S., Free PMC Article | 08/29/2020 |
| LSL-Kras(G12D);Trp53(fl/fl) (KP)-mediated lung adenocarcinomas can develop through both PKCiota-dependent and PKCiota-independent pathways. | Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma.
Yin N, Liu Y, Khoor A, Wang X, Thompson EA, Leitges M, Justilien V, Weems C, Murray NR, Fields AP., Free PMC Article | 04/25/2020 |
| these findings suggest that miR-29c is a negative regulator of axonal growth of dorsal root ganglia neurons by targeting PRKCI under hyperglycemia. | MiR-29c/PRKCI Regulates Axonal Growth of Dorsal Root Ganglia Neurons Under Hyperglycemia.
Jia L, Wang L, Chopp M, Li C, Zhang Y, Szalad A, Zhang ZG., Free PMC Article | 12/22/2018 |
| PKClambda/iota emerges as a critical regulator of Th17 differentiation and allergic airway hyperresponsiveness. | PKCλ/ι regulates Th17 differentiation and house dust mite-induced allergic airway inflammation.
Yang Y, Dong P, Zhao J, Zhou W, Zhou Y, Xu Y, Mei C, Guo F, Zheng Y, Yang JQ. | 04/28/2018 |
| This study demonstrated hat under physiological conditions, PKCiota/lambda is essential for hippocampal early-LTP and long-term memory. | Learning-Induced Suboptimal Compensation for PKCι/λ Function in Mutant Mice.
Sheng T, Wang S, Qian D, Gao J, Ohno S, Lu W. | 03/24/2018 |
| the aPKC-CBP pathway is a homeostatic compensatory mechanism that modulates hippocampal neurogenesis and memory in an age-dependent manner in response to reduced CREB activity. | The aPKC-CBP Pathway Regulates Adult Hippocampal Neurogenesis in an Age-Dependent Manner.
Gouveia A, Hsu K, Niibori Y, Seegobin M, Cancino GI, He L, Wondisford FE, Bennett S, Lagace D, Frankland PW, Wang J., Free PMC Article | 11/25/2017 |
| he oncogenic activity of PRKCI relates in part to the up-regulation of TNFalpha to promote an immune-suppressive tumor microenvironment characterized by an abundance of myeloid-derived suppressor cells and inhibition of cytotoxic T-cell infiltration | PRKCI promotes immune suppression in ovarian cancer.
Sarkar S, Bristow CA, Dey P, Rai K, Perets R, Ramirez-Cardenas A, Malasi S, Huang-Hobbs E, Haemmerle M, Wu SY, McGuire M, Protopopov A, Jiang S, Liu JF, Hirsch MS, Chang Q, Lazar AJ, Sood AK, Drapkin R, DePinho R, Draetta G, Chin L., Free PMC Article | 10/28/2017 |
| Selective deletion of the aPKC isoform Pkc-lambda in proopiomelanocortin (POMC) neurons disrupts leptin action, reduces melanocortin content in the paraventricular nucleus, and markedly increases susceptibility to obesity, glucose intolerance, and insulin resistance specifically in HFD-fed male mice. | Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.
Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP., Free PMC Article | 06/24/2017 |
| results identify a novel role of PHLPP in regulating aPKC and cell polarity. | Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C.
Xiong X, Li X, Wen YA, Gao T., Free PMC Article | 05/27/2017 |
| Prkci and its downstream partners direct polarized cell division of luminal myocardial cells to drive trabeculation in the nascent heart. | Atypical Protein Kinase C-Dependent Polarized Cell Division Is Required for Myocardial Trabeculation.
Passer D, van de Vrugt A, Atmanli A, Domian IJ., Free PMC Article | 11/12/2016 |
| Prkci regulates expansion of various stem cells via Notch-dependent pathway. | Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway.
Mah IK, Soloff R, Hedrick SM, Mariani FV., Free PMC Article | 08/27/2016 |
| PKClambda/iota could be a crucial regulator of mitochondrial function and energy metabolism in stem cells and other cellular contexts | Regulation of mitochondrial function and cellular energy metabolism by protein kinase C-λ/ι: a novel mode of balancing pluripotency.
Mahato B, Home P, Rajendran G, Paul A, Saha B, Ganguly A, Ray S, Roy N, Swerdlow RH, Paul S., Free PMC Article | 08/29/2015 |
| Asymmetric division and CD8+ T lymphocyte fate specification is regulated by protein kinase Czeta and protein kinase Clambda. | Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι.
Metz PJ, Arsenio J, Kakaradov B, Kim SH, Remedios KA, Oakley K, Akimoto K, Ohno S, Yeo GW, Chang JT., Free PMC Article | 04/25/2015 |
| adenoviral-mediated supplementation of hepatic PKC-lambda induced a diabetic state in heterozygous PKC-lambda knockout mice. | PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.
Sajan MP, Ivey RA 3rd, Lee M, Mastorides S, Jurczak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV., Free PMC Article | 04/18/2015 |
| Data indicate that pseudosubstrate arginine residues are key regulators of atypical protein kinase C-lambda and atypical protein kinase C-zeta. | Requirements for pseudosubstrate arginine residues during autoinhibition and phosphatidylinositol 3,4,5-(PO₄)₃-dependent activation of atypical PKC.
Ivey RA, Sajan MP, Farese RV., Free PMC Article | 01/31/2015 |
| Loss of aPKClambda in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains. | Loss of aPKCλ in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains.
Yamanaka T, Tosaki A, Kurosawa M, Akimoto K, Hirose T, Ohno S, Hattori N, Nukina N., Free PMC Article | 09/20/2014 |
| Down-regulation of aPKC, involved in cell polarity, decreases the number of apical nuclei and doubles the number of asymmetric divisions. | The basal position of nuclei is one pre-requisite for asymmetric cell divisions in the early mouse embryo.
Ajduk A, Biswas Shivhare S, Zernicka-Goetz M., Free PMC Article | 09/20/2014 |
| Data demonstrate that PKCiota is required for a tumor-initiating cell phenotype in ovarian cancer. | PKCι maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis.
Wang Y, Hill KS, Fields AP., Free PMC Article | 08/9/2014 |
| PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes. | Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) λ/ι.
Worthmann K, Leitges M, Teng B, Sestu M, Tossidou I, Samson T, Haller H, Huber TB, Schiffer M., Free PMC Article | 07/5/2014 |
| Phosphatidylinositol-3,4,5-triphosphate but not phosphatidylinositol-4,5-biphosphate plays an important role in GLUT4 upregulation and glucose metabolism mediated by AKT/PKCzeta/lambda phosphorylation. | PIP3 but not PIP2 increases GLUT4 surface expression and glucose metabolism mediated by AKT/PKCζ/λ phosphorylation in 3T3L1 adipocytes.
Manna P, Jain SK., Free PMC Article | 02/15/2014 |
| FGF21 inhibits hepatic glucose production by the PI3K-dependent activation of protein kinase c iota. | FGF21 suppresses hepatic glucose production through the activation of atypical protein kinase Cι/λ.
Kong LJ, Feng W, Wright M, Chen Y, Dallas-yang Q, Zhou YP, Berger JP. | 02/8/2014 |
| aPKClambda is critical for PDGF-induced actin cytoskeletal reorganization and cell migration. | Atypical protein kinase Cλ is critical for growth factor receptor-induced dorsal ruffle turnover and cell migration.
Xing B, Wang L, Guo D, Huang J, Espenel C, Kreitzer G, Zhang JJ, Guo L, Huang XY., Free PMC Article | 01/25/2014 |