| The Light Chain Allosterically Enhances the Protease Activity of Murine Urokinase-Type Plasminogen Activator. | The Light Chain Allosterically Enhances the Protease Activity of Murine Urokinase-Type Plasminogen Activator.
Torres-Paris C, Song HJ, Engelberger F, Ramírez-Sarmiento CA, Komives EA., Free PMC Article | 09/3/2024 |
| Decreased fertility in female mice lacking urokinase plasminogen activator. | Decreased fertility in female mice lacking urokinase plasminogen activator.
Laurenzi G, Fedeli V, Canipari R. | 04/2/2024 |
| Urokinase-type plasminogen activator promotes corneal epithelial migration and nerve regeneration. | Urokinase-type plasminogen activator promotes corneal epithelial migration and nerve regeneration.
Sugioka K, Nishida T, Kodama-Takahashi A, Murakami J, Fukuda M, Matsuo O, Kusaka S. | 07/25/2023 |
| Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44(+)-ENaC signal cascade. | Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44(+)-ENaC signal cascade.
Ali G, Zhang M, Zhao R, Jain KG, Chang J, Komatsu S, Zhou B, Liang J, Matthay MA, Ji HL., Free PMC Article | 03/26/2022 |
| BMP2 downregulates urokinase-type plasminogen activator via p38 MAPK: Implications in C2C12 cells myogenic differentiation. | BMP2 downregulates urokinase-type plasminogen activator via p38 MAPK: Implications in C2C12 cells myogenic differentiation.
Santibanez JF, Obradović H, Krstić J. | 01/15/2022 |
| The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation. | The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation.
Vorstandlechner V, Laggner M, Copic D, Klas K, Direder M, Chen Y, Golabi B, Haslik W, Radtke C, Tschachler E, Hötzenecker K, Ankersmit HJ, Mildner M., Free PMC Article | 12/4/2021 |
| GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling. | GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling.
Peng W, Wu Y, Zhang G, Zhu W, Chang M, Rouzi A, Jiang W, Tong L, Wang Q, Liu J, Song Y, Li H, Li K, Zhou J., Free PMC Article | 11/27/2021 |
| PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice. | PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.
Cheng YW, Zhang ZB, Lan BD, Lin JR, Chen XH, Kong LR, Xu L, Ruan CC, Gao PJ., Free PMC Article | 11/27/2021 |
| Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse. | Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse.
Merino P, Diaz A, Torre ER, Yepes M., Free PMC Article | 09/19/2020 |
| The urokinase-type plasminogen activator system as drug target in retinitis pigmentosa: New pre-clinical evidence in the rd10 mouse model. | The urokinase-type plasminogen activator system as drug target in retinitis pigmentosa: New pre-clinical evidence in the rd10 mouse model.
Cammalleri M, Dal Monte M, Locri F, Pecci V, De Rosa M, Pavone V, Bagnoli P., Free PMC Article | 08/15/2020 |
| upregulation of uPA does not alter lung inflammation but is associated with improved epithelial cell homeostasis in a mouse model of lung fibrosis | Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis.
Horowitz JC, Tschumperlin DJ, Kim KK, Osterholzer JJ, Subbotina N, Ajayi IO, Teitz-Tennenbaum S, Virk A, Dotson M, Liu F, Sicard D, Jia S, Sisson TH., Free PMC Article | 07/11/2020 |
| uPA may play a substantial role in insulin secretion, beta cell regeneration, and progressive development of T2DM. | Deficiency of Urokinase Plasminogen Activator May Impair β Cells Regeneration and Insulin Secretion in Type 2 Diabetes Mellitus.
Wu CZ, Ou SH, Chang LC, Lin YF, Pei D, Chen JS., Free PMC Article | 04/18/2020 |
| results point towards an early activation of Notch signaling pathway at the receptor-ligand level in inflammation-associated colon neoplasmatogenesis developed in the absence of uPA. Interestingly, such activation may not be accompanied by deregulation of downstream Notch-target genes, possibly due to the effects of other inter-related signaling pathways. | Inflammation-induced colon cancer in uPA-deficient mice is associated with a deregulated expression of Notch signaling pathway components.
Afaloniati H, Karagiannis GS, Karavanis E, Psarra TA, Karampatzakis-Kouritas A, Poutahidis T, Angelopoulou K. | 03/21/2020 |
| Plau and Tgfbr3 are YAP-regulated genes that promote keratinocyte proliferation. | Plau and Tgfbr3 are YAP-regulated genes that promote keratinocyte proliferation.
Corley SM, Mendoza-Reinoso V, Giles N, Singer ES, Common JE, Wilkins MR, Beverdam A., Free PMC Article | 12/14/2019 |
| The findings of this indicated that Plau/Plaur-deficiency leads to a more social phenotype toward other mice with diminished interest in the surrounding environment, and increased seizure susceptibility | Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility.
Kyyriäinen J, Bolkvadze T, Koivisto H, Lipponen A, Pérez LO, Ekolle Ndode-Ekane X, Tanila H, Pitkänen A. | 07/13/2019 |
| In summary, the data show that urokinase-type plasminogen activator/ the urokinase-type plasminogen activator receptor binding promotes synaptic repair in the ischemic brain via ezrin-mediated reorganization of the actin cytoskeleton in the postsynaptic terminal. | Urokinase-type plasminogen activator (uPA) promotes ezrin-mediated reorganization of the synaptic cytoskeleton in the ischemic brain.
Merino P, Diaz A, Manrique LG, Cheng L, Yepes M., Free PMC Article | 01/26/2019 |
| downregulation of uPA could decrease the fertility of male mice, which may be caused by a reduction in sperm motility. | Tissue-specific inhibition of urokinase-type plasminogen activator expression in the testes of mice by inducible lentiviral RNA interference causes male infertility.
Zhao K, Liu Y, Xiong Z, Hu L, Xiong CL. | 07/21/2018 |
| data presented here reveal important information about dynamics in uPA by demonstrating how various ligands can modulate uPA activity by mediating long-range conformational changes | Ligand binding modulates the structural dynamics and activity of urokinase-type plasminogen activator: A possible mechanism of plasminogen activation.
Kromann-Hansen T, Lange EL, Lund IK, Høyer-Hansen G, Andreasen PA, Komives EA., Free PMC Article | 04/7/2018 |
| Lymphangioleiomyomatosis is fatal lung disease associated with germline/somatic inactivating mutations in TSC2 genes. Data suggest lung lymphangioleiomyomatosis lesions and renal angiomyolipomas overexpress uPA; Tsc2-/- (or Tsc1-/-) embryonic fibroblasts from knockout mice express higher uPA levels than wild-type cells. (uPA = urokinase-type plasminogen activator; Tsc = tuberous sclerosis complex protein) | Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors.
Stepanova V, Dergilev KV, Holman KR, Parfyonova YV, Tsokolaeva ZI, Teter M, Atochina-Vasserman EN, Volgina A, Zaitsev SV, Lewis SP, Zabozlaev FG, Obraztsova K, Krymskaya VP, Cines DB., Free PMC Article | 01/27/2018 |
| The findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis. | Inflammation-driven colon neoplasmatogenesis in uPA-deficient mice is associated with an increased expression of Runx transcriptional regulators.
Afaloniati H, Karagiannis GS, Hardas A, Poutahidis T, Angelopoulou K. | 12/2/2017 |
| an intricate link between caveolin-1 and Src kinase-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C expression through p53 and uPA system-mediated cross-talk, is reported. | Regulation of p53-mediated changes in the uPA-fibrinolytic system and in lung injury by loss of surfactant protein C expression in alveolar epithelial cells.
Puthusseri B, Marudamuthu A, Tiwari N, Fu J, Idell S, Shetty S., Free PMC Article | 08/5/2017 |
| These studies identify uPA-dependent de-repression of vegfr1 and vegfr2 gene transcription through binding to HHEX/PRH as a novel mechanism by which uPA mediates the pro-angiogenic effects of VEGF and identifies a potential new target for control of pathologic angiogenesis. | Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression.
Stepanova V, Jayaraman PS, Zaitsev SV, Lebedeva T, Bdeir K, Kershaw R, Holman KR, Parfyonova YV, Semina EV, Beloglazova IB, Tkachuk VA, Cines DB., Free PMC Article | 04/8/2017 |
| Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models. | Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.
Chen JS, Chang LC, Wu CZ, Tseng TL, Lin JA, Lin YF, Cheng CW., Free PMC Article | 10/22/2016 |
| GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model. | GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.
Lam RS, O'Brien-Simpson NM, Hamilton JA, Lenzo JC, Holden JA, Brammar GC, Orth RK, Tan Y, Walsh KA, Fleetwood AJ, Reynolds EC. | 06/28/2016 |
| Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI. | Epileptogenesis after traumatic brain injury in Plau-deficient mice.
Bolkvadze T, Rantala J, Puhakka N, Andrade P, Pitkänen A. | 06/11/2016 |