| SENP2-PLCbeta4 signaling regulates neurogenesis through the maintenance of calcium homeostasis. | SENP2-PLCβ4 signaling regulates neurogenesis through the maintenance of calcium homeostasis.
Chen X, Qin Y, Zhang Y, Yang X, Xing Z, Shen Y, Cheng J, Yeh ETH, Wu H, Qi Y., Free PMC Article | 07/9/2022 |
| Destabilization of light NREM sleep by thalamic PLCbeta4 deletion impairs sleep-dependent memory consolidation. | Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation.
Hong J, Ha GE, Kwak H, Lee Y, Jeong H, Suh PG, Cheong E., Free PMC Article | 12/12/2020 |
| Thrombosis suppression by heterozygous Plcb4 loss of function was confirmed through analysis of an independent, CRISPR/Cas9-induced Plcb4 mutation in transgenic mice. | Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse.
Tomberg K, Westrick RJ, Kotnik EN, Cleuren AC, Siemieniak DR, Zhu G, Saunders TL, Ginsburg D., Free PMC Article | 01/19/2019 |
| The results of our study showed that thalamic mGluR1-PLCbeta4 pathway was critical in controlling sleep architecture. | The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture.
Hong J, Lee J, Song K, Ha GE, Yang YR, Ma JS, Yamamoto M, Shin HS, Suh PG, Cheong E., Free PMC Article | 11/11/2017 |
| Tnis study demonistrated that plc beta4 distribuate in mice cerebellum | Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.
Sekerková G, Watanabe M, Martina M, Mugnaini E., Free PMC Article | 10/18/2014 |
| Presence of PLCbeta(4) in the heart and in HL-1 cardiomyocytes showing a different species-dependent pattern of expression of the PLCbeta((1-4)) transcripts. | Phospholipase Cbeta4 isozyme is expressed in human, rat, and murine heart left ventricles and in HL-1 cardiomyocytes.
Otaegui D, Querejeta R, Arrieta A, Lazkano A, Bidaurrazaga A, Arriandiaga JR, Aldazabal P, Garro MA. | 06/28/2010 |
| impaired LGNd relay, possibly mediated via group-1 mGluR, may underlie irregular sleep sequences and ultradian body temperature rhythms in PLC-beta4-/- mice | Phospholipase C-beta4 is essential for the progression of the normal sleep sequence and ultradian body temperature rhythms in mice.
Ikeda M, Hirono M, Sugiyama T, Moriya T, Ikeda-Sagara M, Eguchi N, Urade Y, Yoshioka T., Free PMC Article | 05/3/2010 |
| deletion of thalamic PLCbeta4 leads to the genesis of absence seizures | Deletion of phospholipase C beta4 in thalamocortical relay nucleus leads to absence seizures.
Cheong E, Zheng Y, Lee K, Lee J, Kim S, Sanati M, Lee S, Kim YS, Shin HS., Free PMC Article | 02/22/2010 |
| These findings suggest that (1) PLC-beta 4 in the medial septum is involved in controlling cholinergic theta oscillation and (2) cholinergic theta rhythm plays a critical role in suppressing anxiety. | Phospholipase C beta 4 in the medial septum controls cholinergic theta oscillations and anxiety behaviors.
Shin J, Gireesh G, Kim SW, Kim DS, Lee S, Kim YS, Watanabe M, Shin HS., Free PMC Article | 01/25/2010 |
| In this study identify phospholipase C (PLC) beta4 as an antigenic marker of a novel subset of unipolar brush cells. Double immunolabeling reveals that most members of the mGluR1alpha subset also express PLCbeta4. | Phospholipase Cbeta4 expression identifies a novel subset of unipolar brush cells in the adult mouse cerebellum.
Chung SH, Marzban H, Watanabe M, Hawkes R. | 01/21/2010 |
| In pilocarpine-induced status epilepticus, induced expression of PLCbeta4 in the stratum pyramidale of CA1 area was observed. | mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice.
Liu JX, Tang YC, Liu Y, Tang FR. | 01/21/2010 |
| Our study also highlights the thalamic PLCbeta4-PKC pathway as a "molecular switch" for the firing modes of TC neurons and thus for pain sensory gating. | Tuning thalamic firing modes via simultaneous modulation of T- and L-type Ca2+ channels controls pain sensory gating in the thalamus.
Cheong E, Lee S, Choi BJ, Sun M, Lee CJ, Shin HS., Free PMC Article | 01/21/2010 |
| PLCbeta4 levels oscillate in the suprachiasmatic nucleus of mice housed in a light:dark photoperiod | Daily oscillation of phospholipase C beta4 in the mouse suprachiasmatic nucleus.
Jenkins TC, Andrews JB, Meyer-Bernstein EL. | 01/21/2010 |
| excitatory synaptic inputs to Purinje cells activate the Ca2+-assisted mGluR1-PLCbeta4 cascade, and produce 2-arachidonoylglycerol, which retrogradely modulates synaptic transmission | Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum.
Maejima T, Oka S, Hashimotodani Y, Ohno-Shosaku T, Aiba A, Wu D, Waku K, Sugiura T, Kano M., Free PMC Article | 01/21/2010 |
| The role of PLCbeta4 in thalamic neurons during sleep stages. | Effect of phospholipase Cbeta4 lacking in thalamic neurons on electroencephalogram.
Kameyama M, Yamaguchi I, Ichikawa K, Sugiyama T, Hirono M, Hori H, Ikeda M, Kuwahata Y, Eguchi N, Urade Y, Yoshioka T. | 01/21/2010 |
| These findings indicate that the thalamic mGluR1-PLCbeta4 cascade is indispensable for the formalin-induced inflammatory pain by regulating the response of VPL neurons | Role of thalamic phospholipase C[beta]4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain.
Miyata M, Kashiwadani H, Fukaya M, Hayashi T, Wu D, Suzuki T, Watanabe M, Kawakami Y., Free PMC Article | 01/21/2010 |
| The PLCbeta4 expression pattern can be traced continuously from embryo to adult, revealing the continuity of the topographical map from perinatal to adult cerebella. | Phospholipase Cbeta4 expression reveals the continuity of cerebellar topography through development.
Marzban H, Chung S, Watanabe M, Hawkes R. | 01/21/2010 |
| Expression of Plcb4 was studied in a cell line during myoblast differentiation. | Expression of phospholipase C beta family isoenzymes in C2C12 myoblasts during terminal differentiation.
Faenza I, Bavelloni A, Fiume R, Santi P, Martelli AM, Maria Billi A, Lo Vasco VR, Manzoli L, Cocco L. | 01/21/2010 |
| plcb4 expressed strongly in the mouse cerebellum in subsets of Purkinje cells.PLCbeta4 expression is restricted to, and coextensive with, the zebrin II-immunonegative Purkinje cell subset. | Complementary stripes of phospholipase Cbeta3 and Cbeta4 expression by Purkinje cell subsets in the mouse cerebellum.
Sarna JR, Marzban H, Watanabe M, Hawkes R. | 01/21/2010 |
| PLCB4 has a role in synapse elimination and plasticity in developing and mature cerebellum. | Roles of phospholipase Cbeta4 in synapse elimination and plasticity in developing and mature cerebellum.
Hashimoto K, Miyata M, Watanabe M, Kano M. | 01/21/2010 |
| We report here a normal distribution of midbrain dopaminergic cell bodies and axonal projection to the striatum in phospholipase C beta 4-/- mice. | Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival.
Smits SM, van der Nobelen S, Hornman KJ, von Oerthel L, Burbach JP, Smidt MP. | 01/21/2010 |