| Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma. | Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma.
Žugec M, Furlani B, Castañon MJ, Rituper B, Fischer I, Broggi G, Caltabiano R, Barbagallo GMV, Di Rosa M, Tibullo D, Parenti R, Vicario N, Simčič S, Pozo Devoto VM, Stokin GB, Wiche G, Jorgačevski J, Zorec R, Potokar M., Free PMC Article | 02/5/2024 |
| Novel biallelic variants in the PLEC gene are associated with severe hearing loss. | Novel biallelic variants in the PLEC gene are associated with severe hearing loss.
Zhang T, Xu Z, Zheng D, Wang X, He J, Zhang L, Zallocchi M. | 07/14/2023 |
| Plectin ensures intestinal epithelial integrity and protects colon against colitis. | Plectin ensures intestinal epithelial integrity and protects colon against colitis.
Krausova A, Buresova P, Sarnova L, Oyman-Eyrilmez G, Skarda J, Wohl P, Bajer L, Sticova E, Bartonova L, Pacha J, Koubkova G, Prochazka J, Spörrer M, Dürrbeck C, Stehlikova Z, Vit M, Ziolkowska N, Sedlacek R, Jirak D, Kverka M, Wiche G, Fabry B, Korinek V, Gregor M., Free PMC Article | 12/25/2021 |
| Plectin regulates Wnt signaling mediated-skeletal muscle development by interacting with Dishevelled-2 and antagonizing autophagy. | Plectin regulates Wnt signaling mediated-skeletal muscle development by interacting with Dishevelled-2 and antagonizing autophagy.
Yin H, Han S, Cui C, Wang Y, Li D, Zhu Q. | 04/24/2021 |
| Our study shows that by maintaining proper keratin network cytoarchitecture and biliary epithelial stability, plectin plays a critical role in protecting the liver from stress elicited by cholestasis. | Plectin controls biliary tree architecture and stability in cholestasis.
Jirouskova M, Nepomucka K, Oyman-Eyrilmez G, Kalendova A, Havelkova H, Sarnova L, Chalupsky K, Schuster B, Benada O, Miksatkova P, Kuchar M, Fabian O, Sedlacek R, Wiche G, Gregor M. | 09/21/2019 |
| data demonstrate that plectin is an essential regulator of nuclear morphology in vitro and in vivo and protects the nucleus from mechanical deformation. | The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes.
Almeida FV, Walko G, McMillan JR, McGrath JA, Wiche G, Barber AH, Connelly JT. | 09/24/2016 |
| Data demonstrate that rodless plectin can functionally compensate for the loss of full-length plectin in mice. | The rod domain is not essential for the function of plectin in maintaining tissue integrity.
Ketema M, Secades P, Kreft M, Nahidiazar L, Janssen H, Jalink K, de Pereda JM, Sonnenberg A., Free PMC Article | 04/30/2016 |
| results show that the depletion of distinct plectin isoforms affects mitochondrial network organization and function in different ways. | Plectin isoform P1b and P1d deficiencies differentially affect mitochondrial morphology and function in skeletal muscle.
Winter L, Kuznetsov AV, Grimm M, Zeöld A, Fischer I, Wiche G., Free PMC Article | 04/9/2016 |
| Binding of calcium-calmodulin (Ca(2+)-CaM) to P1a together with phosphorylation of integrin beta 4 disrupts the complex, resulting in disassembly of hemidesmosomes. | Structural insights into Ca2+-calmodulin regulation of Plectin 1a-integrin β4 interaction in hemidesmosomes.
Song JG, Kostan J, Drepper F, Knapp B, de Almeida Ribeiro E Jr, Konarev PV, Grishkovskaya I, Wiche G, Gregor M, Svergun DI, Warscheid B, Djinović-Carugo K., Free PMC Article | 12/5/2015 |
| Plectin bridges acetylcholine receptors and intermediate filaments via direct interaction with the AChR-scaffolding protein rapsyn in an isoform-specific manner. | Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn-plectin 1f complexes.
Mihailovska E, Raith M, Valencia RG, Fischer I, Al Banchaabouchi M, Herbst R, Wiche G., Free PMC Article | 08/22/2015 |
| the lack of plectin has divergent implications on biomechanical properties depending on the respective cell type. | Determining the mechanical properties of plectin in mouse myoblasts and keratinocytes.
Bonakdar N, Schilling A, Spörrer M, Lennert P, Mainka A, Winter L, Walko G, Wiche G, Fabry B, Goldmann WH., Free PMC Article | 04/25/2015 |
| Ablation of plectin in myelinating Schwann cells is found not to affect myelin sheath formation. | Stabilization of the dystroglycan complex in Cajal bands of myelinating Schwann cells through plectin-mediated anchorage to vimentin filaments.
Walko G, Wögenstein KL, Winter L, Fischer I, Feltri ML, Wiche G. | 03/15/2014 |
| Nesprin-3 is critical for the localization of plectin to the nuclear perimeter of Sertoli cells. | Nesprin-3 connects plectin and vimentin to the nuclear envelope of Sertoli cells but is not required for Sertoli cell function in spermatogenesis.
Ketema M, Kreft M, Secades P, Janssen H, Sonnenberg A., Free PMC Article | 03/1/2014 |
| findings suggest a mechanism for microtubule(MT)destabilization in which isoform-specific binding of P1c to MTs antagonizes the MT-stabilizing and assembly-promoting function of MT-associated proteins through an inhibitory function exerted by plectin's SH3 domain | Intermediate filament-associated cytolinker plectin 1c destabilizes microtubules in keratinocytes.
Valencia RG, Walko G, Janda L, Novacek J, Mihailovska E, Reipert S, Andrä-Marobela K, Wiche G., Free PMC Article | 09/14/2013 |
| plectin 1a, the major isoform expressed in epidermal keratinocytes, is proteolytically degraded, supporting the notion that degradation of hemidesmosome-anchored plectin is spatially controlled. | Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna.
Walko G, Vukasinovic N, Gross K, Fischer I, Sibitz S, Fuchs P, Reipert S, Jungwirth U, Berger W, Salzer U, Carugo O, Castañón MJ, Wiche G., Free PMC Article | 03/3/2012 |
| two genes identified in this analysis, PLEC1 and TPST1, reduced IL-6 production by macrophages | Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands.
Yang IV, Jiang W, Rutledge HR, Lackford B, Warg LA, De Arras L, Alper S, Schwartz DA, Pisetsky DS., Free PMC Article | 10/29/2011 |
| Mature focal adhesions and their derivative fibronectin fibril-aligned fibrillar adhesions (FbAs) serve as docking sites for vimentin intermediate filaments (IFs) in a plectin isoform 1f (P1f)-dependent manner. | Keeping the vimentin network under control: cell-matrix adhesion-associated plectin 1f affects cell shape and polarity of fibroblasts.
Burgstaller G, Gregor M, Winter L, Wiche G., Free PMC Article | 01/22/2011 |
| BPAG1-b was detectable in vitro and in vivo as a high molecular mass protein in striated and heart muscle cells, co-localizing with alpha-actinin-2 and partially with the cytolinker plectin as well as with the intermediate filament protein desmin. | BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin.
Steiner-Champliaud MF, Schneider Y, Favre B, Paulhe F, Praetzel-Wunder S, Faulkner G, Konieczny P, Raith M, Wiche G, Adebola A, Liem RK, Langbein L, Sonnenberg A, Fontao L, Borradori L. | 03/1/2010 |
| Studies demonstrate an important role of plectin in a major nerve function. | Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity.
Fuchs P, Zörer M, Reipert S, Rezniczek GA, Propst F, Walko G, Fischer I, Bauer J, Leschnik MW, Lüscher B, Thalhammer JG, Lassmann H, Wiche G., Free PMC Article | 01/21/2010 |
| novel model for the disassembly of hemidesmosomes where both binding of calmodulin to plectin 1a and phosphorylation of integrin beta4 by protein kinases, are required for disruption of the integrin alpha6beta4-plectin complex | Plectin isoform-dependent regulation of keratin-integrin alpha6beta4 anchorage via Ca2+/calmodulin.
Kostan J, Gregor M, Walko G, Wiche G., Free PMC Article | 01/21/2010 |
| Plectin contributes to mechanical properties of living cells. | Plectin contributes to mechanical properties of living cells.
Na S, Chowdhury F, Tay B, Ouyang M, Gregor M, Wang Y, Wiche G, Wang N., Free PMC Article | 01/21/2010 |
| plectin prevents vimentin networks from complete disassembly during mitosis, facilitating the rebuilding of the intermediate filament network in daughter cells. | Plectin deficiency affects precursor formation and dynamics of vimentin networks.
Spurny R, Gregor M, Castañón MJ, Wiche G. | 01/21/2010 |
| Plectin 1b both forms a mitochondrial signaling platform and affects organelle shape and network formation by tethering mitochondria to intermediate filaments. | Plectin isoform 1b mediates mitochondrion-intermediate filament network linkage and controls organelle shape.
Winter L, Abrahamsberg C, Wiche G., Free PMC Article | 01/21/2010 |
| These findings establish plectin as the major organizer of desmin IFs in myofibers and provide new insights into plectin- and desmin-related muscular dystrophies. | Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms.
Konieczny P, Fuchs P, Reipert S, Kunz WS, Zeöld A, Fischer I, Paulin D, Schröder R, Wiche G., Free PMC Article | 01/21/2010 |
| Expression of plectin 1a, but not of its N-terminal fragment alone, or of a third alternative full length isoform (plectin 1), restored the reduced number of hemidesmosome-like stable anchoring contacts in cultured plectin-null keratinocytes | Plectin-isoform-specific rescue of hemidesmosomal defects in plectin (-/-) keratinocytes.
Andrä K, Kornacker I, Jörgl A, Zörer M, Spazierer D, Fuchs P, Fischer I, Wiche G. | 01/21/2010 |