| Long noncoding RNA MAPKAPK5-AS1 promotes metastasis through regulation miR-376b-5p/ECT2 axis in hepatocellular carcinoma. | Long noncoding RNA MAPKAPK5-AS1 promotes metastasis through regulation miR-376b-5p/ECT2 axis in hepatocellular carcinoma.
Lv E, Sheng J, Yu C, Rao D, Huang W. | 06/30/2023 |
| miRNA-223-3p regulates ECT2 to promote proliferation, invasion, and metastasis of gastric cancer through the Wnt/beta-catenin signaling pathway. | miRNA-223-3p regulates ECT2 to promote proliferation, invasion, and metastasis of gastric cancer through the Wnt/β-catenin signaling pathway.
Li L, Liu P, He C, Xu C. | 02/4/2023 |
| ECT2 promotes malignant phenotypes through the activation of the AKT/mTOR pathway and cisplatin resistance in cervical cancer. | ECT2 promotes malignant phenotypes through the activation of the AKT/mTOR pathway and cisplatin resistance in cervical cancer.
Liu X, Zhang J, Ju S, Liu L, Sun Y, Guo L, Zhen Q, Han S, Lu W, Zhang Y. | 01/21/2023 |
| CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway. | CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.
Wen C, Li Y, Huang Y, Wang N, He S, Bao M, Zhou H, Wu L. | 01/11/2023 |
| Cytokinetic diversity in mammalian cells is revealed by the characterization of endogenous anillin, Ect2 and RhoA. | Cytokinetic diversity in mammalian cells is revealed by the characterization of endogenous anillin, Ect2 and RhoA.
Husser MC, Ozugergin I, Resta T, Martin VJJ, Piekny AJ., Free PMC Article | 12/3/2022 |
| Integrated Analysis of ECT2 and COL17A1 as Potential Biomarkers for Pancreatic Cancer. | Integrated Analysis of ECT2 and COL17A1 as Potential Biomarkers for Pancreatic Cancer.
Huang WL, Wu SF, Huang X, Zhou S., Free PMC Article | 06/25/2022 |
| Low Expression of ECT2 Confers Radiation Therapy Resistance Through Transcription Coupled Nucleolar DNA Damage Repair. | Low Expression of ECT2 Confers Radiation Therapy Resistance Through Transcription Coupled Nucleolar DNA Damage Repair.
Qiu Y, Hu W, Wen M, Zhao W, Xie J, Zhang J, Wang M, Li H, Zhao Y, Fu S, Rong Z, Yao M, Duan Y, Huang J, Wang Y, Qin J, Wang H, Sun LQ, Tan R. | 04/30/2022 |
| The BRCT domains of ECT2 have distinct functions during cytokinesis. | The BRCT domains of ECT2 have distinct functions during cytokinesis.
Schneid S, Wolff F, Buchner K, Bertram N, Baygün S, Barbosa P, Mangal S, Zanin E. | 01/29/2022 |
| Epithelial cell transforming factor ECT2 is an important regulator of DNA double-strand break repair and genome stability. | Epithelial cell transforming factor ECT2 is an important regulator of DNA double-strand break repair and genome stability.
Cao C, Han P, Liu L, Tang Y, Tian S, Zhang K, Shi L, Liu Z, Zhuo D, Ge W, Gong W., Free PMC Article | 12/11/2021 |
| ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway. | ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway.
Xu D, Wang Y, Wu J, Zhang Z, Chen J, Xie M, Tang R, Chen C, Chen L, Lin S, Luo X, Zheng J., Free PMC Article | 09/18/2021 |
| A feedforward circuit shaped by ECT2 and USP7 contributes to breast carcinogenesis. | A feedforward circuit shaped by ECT2 and USP7 contributes to breast carcinogenesis.
Zhang Q, Cao C, Gong W, Bao K, Wang Q, Wang Y, Bi L, Ma S, Zhao J, Liu L, Tian S, Zhang K, Yang J, Yao Z, Song N, Shi L., Free PMC Article | 06/5/2021 |
| ECT2 promotes proliferation and metastasis of esophageal squamous cell carcinoma via the RhoA-ERK signaling pathway. | ECT2 promotes proliferation and metastasis of esophageal squamous cell carcinoma via the RhoA-ERK signaling pathway.
Sun BY, Wei QQ, Liu CX, Zhang L, Luo G, Li T, Lü MH. | 05/8/2021 |
| Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma. | Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma.
Liu Y, Yin N, Wang X, Khoor A, Sambandam V, Ghosh AB, Fields ZA, Murray NR, Justilien V, Fields AP., Free PMC Article | 03/20/2021 |
| ECT2 promotes lung adenocarcinoma progression through extracellular matrix dynamics and focal adhesion signaling. | ECT2 promotes lung adenocarcinoma progression through extracellular matrix dynamics and focal adhesion signaling.
Kosibaty Z, Murata Y, Minami Y, Noguchi M, Sakamoto N., Free PMC Article | 03/6/2021 |
| Protein kinase Ciota promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells. | Protein kinase Cι promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells.
Justilien V, Lewis KC, Meneses KM, Jamieson L, Murray NR, Fields AP., Free PMC Article | 01/2/2021 |
| These data identify Aletrnative splicing programs controlled by ZRANB2 and SYF2 and converging on ECT2, that participate to breast cancer cell resistance to doxorubicin. | ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin.
Tanaka I, Chakraborty A, Saulnier O, Benoit-Pilven C, Vacher S, Labiod D, Lam EWF, Bièche I, Delattre O, Pouzoulet F, Auboeuf D, Vagner S, Dutertre M., Free PMC Article | 05/23/2020 |
| we clarify a new mechanism by which ECT2 regulates the expression of PTTG1 and thus affects the proliferation of glioma cells | ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizing E2F1.
Zhi T, Jiang K, Xu X, Yu T, Zhou F, Wang Y, Liu N, Zhang J., Free PMC Article | 05/2/2020 |
| the oncogene ECT2 contributes to epithelial cell reprogramming in idiopathic pulmonary fibrosis | The Oncogene ECT2 Contributes to a Hyperplastic, Proliferative Lung Epithelial Cell Phenotype in Idiopathic Pulmonary Fibrosis.
Ulke HM, Mutze K, Lehmann M, Wagner DE, Heinzelmann K, Günther A, Eickelberg O, Königshoff M. | 04/25/2020 |
| Epithelial cell transforming 2 (Ect2) protein activates Rho GTPases and controls cytokinesis and many other cellular processes. Dysregulation of Ect2 is associated with various cancers. | Structure and regulation of human epithelial cell transforming 2 protein.
Chen M, Pan H, Sun L, Shi P, Zhang Y, Li L, Huang Y, Chen J, Jiang P, Fang X, Wu C, Chen Z., Free PMC Article | 04/18/2020 |
| these investigative findings suggest that Calycosin (CC) may play the potential anti-invasive benefits against Osteosarcoma (OS) through suppressing metastasis-associated IkBa/ECT2 molecular pathway | Antimetastatic effects of calycosin on osteosarcoma and the underlying mechanism.
Qiu R, Li X, Qin K, Chen X, Wang R, Dai Y, Deng L, Ye Y. | 04/18/2020 |
| Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC. | Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC.
Justilien V, Lewis KC, Murray NR, Fields AP., Free PMC Article | 04/11/2020 |
| prognostic significance of epithelial cell transforming sequence 2 expression in cancers | Clinicopathological and prognostic significance of epithelial cell transforming sequence 2 expression in cancers: a systematic review and meta-analysis.
Li B, Lin JP, Li Z, Yin C, Yang JB, Meng YQ. | 03/28/2020 |
| Authors used a proteomic approach to identify protein complexes associated with PRICKLE1. The mRNA expression levels of the corresponding genes were assessed in 8982 patients with invasive primary breast cancer. AUthors then characterised the molecular interaction between PRICKLE1 and the guanine nucleotide exchange factor ECT2. | ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer.
Daulat AM, Finetti P, Revinski D, Silveira Wagner M, Camoin L, Audebert S, Birnbaum D, Kodjabachian L, Borg JP, Bertucci F., Free PMC Article | 02/29/2020 |
| Ect2 and Poldip2 are both essential for vascular smooth muscle cell cytokinesis and cell proliferation. | Polymerase-δ-interacting protein 2 activates the RhoGEF epithelial cell transforming sequence 2 in vascular smooth muscle cells.
Huff LP, Kikuchi DS, Faidley E, Forrester SJ, Tsai MZ, Lassègue B, Griendling KK., Free PMC Article | 02/15/2020 |
| Investigated and demonstrated that cytoplasmic expression of epithelial cell transforming 2 protein (ECT2) is a characteristic of lung adenocarcinoma with an aggressive malignant phenotype and poor prognosis. | Cytoplasmic expression of epithelial cell transforming sequence 2 in lung adenocarcinoma and its implications for malignant progression.
Kosibaty Z, Murata Y, Minami Y, Dai T, Kano J, Matsuoka R, Nakano N, Noguchi M. | 10/26/2019 |