| Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1. | Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1.
Yan B, Ai Y, Sun Q, Ma Y, Cao Y, Wang J, Zhang Z, Wang X. | 02/6/2021 |
| Hepatic cytochrome b5/P450 reductase contribute to the bioactivation of ellipticine in vitro, but not in vivo. | Application of hepatic cytochrome b(5)/P450 reductase null (HBRN) mice to study the role of cytochrome b(5) in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.
Reed L, Indra R, Mrizova I, Moserova M, Schmeiser HH, Wolf CR, Henderson CJ, Stiborova M, Phillips DH, Arlt VM., Free PMC Article | 11/2/2019 |
| Knockout of the cytochrome P450 reductase by CRISPR/Cas9 technology (POR(-/-)) in HEK293 cells overexpressing Nox4 or Nox5 did not interfere with ROS production in intact cells. However, POR(-/-) abolished the signal in NADPH-stimulated assays using membrane fractions from the very same cells. Moreover, membranes of rat smooth muscle cells treated with angiotensin II showed an increased NADPH-dependent signal with lucigen | Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays.
Rezende F, Prior KK, Löwe O, Wittig I, Strecker V, Moll F, Helfinger V, Schnütgen F, Kurrle N, Wempe F, Walter M, Zukunft S, Luck B, Fleming I, Weissmann N, Brandes RP, Schröder K. | 12/16/2017 |
| we observed that miR-378 modulates the oscillation amplitudes of Cdkn1a in the control of cell cycle and Por in the regulation of oxidation reduction by forming partnership with different circadian transcription factors | Oscillating primary transcripts harbor miRNAs with circadian functions.
Wang H, Fan Z, Zhao M, Li J, Lu M, Liu W, Ying H, Liu M, Yan J., Free PMC Article | 12/31/2016 |
| Results are the first to show that some forms of opioid-mediated stress-induced analgesia require brain neuronal P450 activity. | Significance of neuronal cytochrome P450 activity in opioid-mediated stress-induced analgesia.
Hough LB, Nalwalk JW, Yang W, Ding X., Free PMC Article | 04/11/2015 |
| Immunological and metabolic changes resulting from a genetic deficiency in CPR expression in the intestine in mice. | Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage.
Ahlawat S, Xie F, Zhu Y, D'Hondt R, Ding X, Zhang QY, Mantis NJ., Free PMC Article | 02/28/2015 |
| An apparent link exists between the cytochrome p450 reductase and FGF signaling pathways. | Conditional deletion of cytochrome p450 reductase in osteoprogenitor cells affects long bone and skull development in mice recapitulating antley-bixler syndrome: role of a redox enzyme in development.
Panda SP, Guntur AR, Polusani SR, Fajardo RJ, Gakunga PT, Roman LJ, Masters BS., Free PMC Article | 07/19/2014 |
| These data collectively indicate a novel role of the Cpr gene in fear conditioning and memory. | Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse model.
Fang C, Bolivar VJ, Gu J, Yang W, Zeitlin SO, Ding X., Free PMC Article | 11/17/2012 |
| this study provides novel insights into the regulation of gap junction function by CYPOR and suggests that Cx43 may play an important role(s) in CYPOR-mediated bone defects seen in patients. | Regulation of gap junction function and Connexin 43 expression by cytochrome P450 oxidoreductase (CYPOR).
Polusani SR, Kar R, Riquelme MA, Masters BS, Panda SP., Free PMC Article | 10/1/2011 |
| Data suggest that cellular cytochrome P450 oxidoreductase-dependent cholesterol synthesis is essential during limb and skeletal development. | Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb.
Schmidt K, Hughes C, Chudek JA, Goodyear SR, Aspden RM, Talbot R, Gundersen TE, Blomhoff R, Henderson C, Wolf CR, Tickle C., Free PMC Article | 01/21/2010 |
| The hepatic deficiency of this enzyme reverberates throughout the biological system and produces a coordinated response to the low levels of circulating cholesterol and bile. | The disruption of hepatic cytochrome p450 reductase alters mouse lipid metabolism.
Mutch DM, Klocke B, Morrison P, Murray CA, Henderson CJ, Seifert M, Williamson G. | 01/21/2010 |
| POR function is indispensable for the proper regulation of retinoic acid levels and tissue distribution not only during early embryonic development but also in later morphogenesis and molecular patterning of the brain, abdominal/caudal region and limbs. | Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis.
Ribes V, Otto DM, Dickmann L, Schmidt K, Schuhbaur B, Henderson C, Blomhoff R, Wolf CR, Tickle C, Dollé P. | 01/21/2010 |
| inactivation of the hepatic cytochrome P450 system by conditional deletion of this enzyme | Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.
Henderson CJ, Otto DM, Carrie D, Magnuson MA, McLaren AW, Rosewell I, Wolf CR. | 01/21/2010 |
| Changes in hepatic mRNA expression using microarray analysis and real-time PCR in POR null mice are reported. | Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice.
Wang XJ, Chamberlain M, Vassieva O, Henderson CJ, Wolf CR., Free PMC Article | 01/21/2010 |