| Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis. | Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis.
Volkmann ER, Denton CP, Kolb M, Wijsenbeek-Lourens MS, Emson C, Hudson K, Amatucci AJ, Distler O, Allanore Y, Khanna D., Free PMC Article | 08/13/2024 |
| Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis. | Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis.
Takagi S, Sasaki Y, Koike S, Takemoto A, Seto Y, Haraguchi M, Ukaji T, Kawaguchi T, Sugawara M, Saito M, Funauchi Y, Ae K, Matsumoto S, Fujita N, Katayama R., Free PMC Article | 07/28/2024 |
| CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake. | CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake.
Nikolaou S, Juin A, Whitelaw JA, Paul NR, Fort L, Nixon C, Spence HJ, Bryson S, Machesky LM., Free PMC Article | 07/11/2024 |
| LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration. | LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration.
Hong JM, Lee JW, Seen DS, Jeong JY, Huh WK., Free PMC Article | 09/29/2023 |
| LPAR1 and aberrantly expressed LPAR3 differentially promote the migration and proliferation of malignant peripheral nerve sheath tumor cells. | LPAR1 and aberrantly expressed LPAR3 differentially promote the migration and proliferation of malignant peripheral nerve sheath tumor cells.
Doutt SW, Longo JF, Carroll SL., Free PMC Article | 01/28/2023 |
| LPAR1 regulates enteric nervous system function through glial signaling and contributes to chronic intestinal pseudo-obstruction. | LPAR1 regulates enteric nervous system function through glial signaling and contributes to chronic intestinal pseudo-obstruction.
Ahmadzai MM, McClain JL, Dharshika C, Seguella L, Giancola F, De Giorgio R, Gulbransen BD., Free PMC Article | 04/2/2022 |
| Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY., Free PMC Article | 03/5/2022 |
| Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-beta/Notch signaling pathway. | Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signaling pathway.
Wang H, Feng Z, Han X, Xing Y, Zhang X. | 02/26/2022 |
| Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance. | Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance.
Liu J, Rebecca VW, Kossenkov AV, Connelly T, Liu Q, Gutierrez A, Xiao M, Li L, Zhang G, Samarkina A, Zayasbazan D, Zhang J, Cheng C, Wei Z, Alicea GM, Fukunaga-Kalabis M, Krepler C, Aza-Blanc P, Yang CC, Delvadia B, Tong C, Huang Y, Delvadia M, Morias AS, Sproesser K, Brafford P, Wang JX, Beqiri M, Somasundaram R, Vultur A, Hristova DM, Wu LW, Lu Y, Mills GB, Xu W, Karakousis GC, Xu X, Schuchter LM, Mitchell TC, Amaravadi RK, Kwong LN, Frederick DT, Boland GM, Salvino JM, Speicher DW, Flaherty KT, Ronai ZA, Herlyn M., Free PMC Article | 01/8/2022 |
| LPA1 Receptor Promotes Progesterone Receptor Phosphorylation through PKCalpha in Human Glioblastoma Cells. | LPA(1) Receptor Promotes Progesterone Receptor Phosphorylation through PKCα in Human Glioblastoma Cells.
Valdés-Rives SA, Arcos-Montoya D, de la Fuente-Granada M, Zamora-Sánchez CJ, Arias-Romero LE, Villamar-Cruz O, Camacho-Arroyo I, Pérez-Tapia SM, González-Arenas A., Free PMC Article | 10/23/2021 |
| Genetic polymorphisms of lysophosphatidic acid receptor 1 are associated with the onset of taxane-induced peripheral neuropathy. | Genetic polymorphisms of lysophosphatidic acid receptor 1 are associated with the onset of taxane-induced peripheral neuropathy.
Tsuchida R, Tanabe Y, Nishizawa D, Ikeda K, Abe H, Inoue R, Kurano M, Yatomi Y, Tamura K, Takano T, Shimizu C, Uchida K, Sumitani M. | 10/16/2021 |
| The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages. | The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages.
Zhang D, Shi R, Xiang W, Kang X, Tang B, Li C, Gao L, Zhang X, Zhang L, Dai R, Miao H., Free PMC Article | 10/16/2021 |
| Lysophosphatidic acid mediated PI3K/Akt activation contributed to esophageal squamous cell cancer progression. | Lysophosphatidic acid mediated PI3K/Akt activation contributed to esophageal squamous cell cancer progression.
Liu S, Jiang H, Min L, Ning T, Xu J, Wang T, Wang X, Zhang Q, Cao R, Zhang S, Zhu S. | 10/2/2021 |
| Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis. | Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis.
Fransson J, Gómez-Conde AI, Romero-Imbroda J, Fernández O, Leyva L, de Fonseca FR, Chun J, Louapre C, Van-Evercooren AB, Zujovic V, Estivill-Torrús G, García-Díaz B. | 09/4/2021 |
| A blocking peptide stabilizes lysophosphatidic acid receptor 1 and promotes lysophosphatidic acid-induced cellular responses. | A blocking peptide stabilizes lysophosphatidic acid receptor 1 and promotes lysophosphatidic acid-induced cellular responses.
Taleb SJ, Wei J, Mialki RK, Dong S, Li Y, Zhao J, Zhao Y., Free PMC Article | 09/4/2021 |
| Microglial lysophosphatidic acid promotes glioblastoma proliferation and migration via LPA1 receptor. | Microglial lysophosphatidic acid promotes glioblastoma proliferation and migration via LPA(1) receptor.
Amaral RF, Geraldo LHM, Einicker-Lamas M, E Spohr TCLS, Mendes F, Lima FRS. | 05/8/2021 |
| Long noncoding RNA ZFAS1 promotes tumorigenesis and metastasis in nasopharyngeal carcinoma by sponging miR-892b to up-regulate LPAR1 expression. | Long noncoding RNA ZFAS1 promotes tumorigenesis and metastasis in nasopharyngeal carcinoma by sponging miR-892b to up-regulate LPAR1 expression.
Peng J, Liu F, Zheng H, Wu Q, Liu S., Free PMC Article | 04/24/2021 |
| LPA1 receptor activation induces PKCalpha nuclear translocation in glioblastoma cells | LPA(1) receptor activation induces PKCα nuclear translocation in glioblastoma cells.
Valdés-Rives SA, de la Fuente-Granada M, Velasco-Velázquez MA, González-Flores O, González-Arenas A. | 01/11/2020 |
| It is a tumor suppressor gene. | Identification of genes with universally upregulated or downregulated expressions in colorectal cancer.
Song K, Su W, Liu Y, Zhang J, Liang Q, Li N, Guan Q, He J, Bai X, Zhao W, Guo Z. | 11/30/2019 |
| findings suggest an LPA1 receptor-dependent pathway by which LPA increases arteriolar release of mitochondria-derived hydrogen peroxide as a mediator of flow-induced dilation | Lysophosphatidic acid acts on LPA(1) receptor to increase H(2) O(2) during flow-induced dilation in human adipose arterioles.
Chabowski DS, Kadlec AO, Ait-Aissa K, Hockenberry JC, Pearson PJ, Beyer AM, Gutterman DD., Free PMC Article | 10/5/2019 |
| his study uncovers an LPA1-EGFR signaling axis that is used for cell invasion in hypoxia and suggests a potential target to impede cancer metastasis | The Hypoxic Tumor Microenvironment Promotes Invadopodia Formation and Metastasis through LPA1 Receptor and EGFR Cooperation.
Harper K, R Lavoie R, Charbonneau M, Brochu-Gaudreau K, Dubois CM. | 08/3/2019 |
| mRNA expression analyses revealed that ADSCs and MES largely expressed LPA receptor 1 (LPAR1) while epithelial cells mainly expressed LPAR6. LPA 18:1 activated all the cell populations and cell lines by rise in cytosolic free calcium concentrations. MES and ADSCs expressed ATX whereas epithelial cells did not. | ADSCs and adipocytes are the main producers in the autotaxin-lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro.
Schmid R, Wolf K, Robering JW, Strauß S, Strissel PL, Strick R, Rübner M, Fasching PA, Horch RE, Kremer AE, Boos AM, Weigand A., Free PMC Article | 03/30/2019 |
| In the presence of LPC, the cell motile activity of PANC-R9 cells was markedly stimulated. In contrast, LPC did not affect the cell motile activity of PANC-1 cells. PANC-R9 cell motility was inhibited by an ATX inhibitor, PF-8380. These results suggest that LPA signaling via LPA1 is a potent molecular target for the regulation of tumor progression in PANC-1 cells. | Promotion of cell-invasive activity through the induction of LPA receptor-1 in pancreatic cancer cells.
Fukushima K, Otagaki S, Takahashi K, Minami K, Ishimoto K, Fukushima N, Honoki K, Tsujiuchi T. | 02/9/2019 |
| These results suggest a common molecular mechanism between myeloid differentiation of leukemia cells and migration of breast cancer cells depending on NM23 and EDG2 expression levels. | NM23 downregulation and lysophosphatidic acid receptor EDG2/lpa1 upregulation during myeloid differentiation of human leukemia cells.
Okabe-Kado J, Hagiwara-Watanabe Y, Niitsu N, Kasukabe T, Kaneko Y. | 01/26/2019 |
| ATX-LPA axis facilitates estrogen-induced endometrial cancer cell proliferation via MAPK/ERK signaling pathway. | ATX‑LPA axis facilitates estrogen‑induced endometrial cancer cell proliferation via MAPK/ERK signaling pathway.
Zhang G, Cheng Y, Zhang Q, Li X, Zhou J, Wang J, Wei L., Free PMC Article | 08/18/2018 |