| Dependence of sperm structural and functional integrity on testicular calcineurin isoform PPP3R2 expression. | Dependence of sperm structural and functional integrity on testicular calcineurin isoform PPP3R2 expression.
Liu Y, Zhang C, Wang S, Hu Y, Jing J, Ye L, Jing R, Ding Z., Free PMC Article | 08/14/2021 |
| surgical-induced Osteoarthritis mice treated with a miR-146a inhibitor significantly alleviated the destruction of articular cartilage via targeting Camk2d and Ppp3r2. | miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2.
Zhang X, Wang C, Zhao J, Xu J, Geng Y, Dai L, Huang Y, Fu SC, Dai K, Zhang X., Free PMC Article | 11/25/2017 |
| this stusy demonstrates that male mice lacking Ppp3cc or Ppp3r2 genes (knockout mice) are infertile, with reduced sperm motility owing to an inflexible midpiece. | Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive.
Miyata H, Satouh Y, Mashiko D, Muto M, Nozawa K, Shiba K, Fujihara Y, Isotani A, Inaba K, Ikawa M. | 04/2/2016 |
| we report that calcineurin subunit B interacted with TLR4, which in turn led to phosphorylaiton of IRF3 and secretion of IFN-beta | Calcineurin subunit B upregulates β-interferon production by phosphorylation of interferon regulatory factor 3 via Toll-like receptor 4.
Wang X, Li L, Huang Y, Wei Q., Free PMC Article | 04/21/2012 |
| The CnB could be of use as a prophylactic adjuvant as it is a human-derived safe agent and has immune-modulating effects that promote the control of cancer and infectious diseases. | Calcineurin subunit B activates dendritic cells and acts as a cancer vaccine adjuvant.
Li J, Guo J, Su Z, Hu M, Liu W, Wei Q. | 01/7/2012 |
| Deactivation of calcineurin/NFAT pathway-induced pathological hypertrophy is a preferential mechanism by which exercise training leads to the cardiac anti-remodelling effect in heart failure. | Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice.
Oliveira RS, Ferreira JC, Gomes ER, Paixão NA, Rolim NP, Medeiros A, Guatimosim S, Brum PC., Free PMC Article | 01/21/2010 |
| neuronal CaN plays an opposite role in the formation of contextual fear memories and the extinction of previously formed contextual fear memories | Transgenic inhibition of neuronal calcineurin activity in the forebrain facilitates fear conditioning, but inhibits the extinction of contextual fear memories.
Havekes R, Nijholt IM, Visser AK, Eisel UL, Van der Zee EA. | 01/21/2010 |
| Together, these findings reveal a previously unknown mechanism for the control of emotional memory that depends on CaN and Zif268. | Control of the establishment of aversive memory by calcineurin and Zif268.
Baumgärtel K, Genoux D, Welzl H, Tweedie-Cullen RY, Koshibu K, Livingstone-Zatchej M, Mamie C, Mansuy IM. | 01/21/2010 |
| By several different criteria, calcineurin is dispensable for B cell tolerance, indicating that this phosphatase complex modulates immunogenic, but not tolerogenic, responses in vivo. | The calcineurin phosphatase complex modulates immunogenic B cell responses.
Winslow MM, Gallo EM, Neilson JR, Crabtree GR. | 01/21/2010 |
| Mice with genetic deletion of the calcineurin Abeta gene had a marked decrease in type II Na/Pi mRNA levels and remarkably did not show the expected increase in type II Na/Pi mRNA levels after the challenge of a low-Pi diet | Calcineurin Abeta is central to the expression of the renal type II Na/Pi co-transporter gene and to the regulation of renal phosphate transport.
Moz Y, Levi R, Lavi-Moshayoff V, Cox KB, Molkentin JD, Silver J, Naveh-Many T. | 01/21/2010 |
| These results suggest that calcineurin-dependent dephosphorylation plays an important role in the mechanisms of action of antidepressants, providing a new starting point for developing improved therapeutic treatments for depression. | Calcineurin (protein phosphatase 2B) is involved in the mechanisms of action of antidepressants.
Crozatier C, Farley S, Mansuy IM, Dumas S, Giros B, Tzavara ET. | 01/21/2010 |
| calcineurin-mediated skeletal muscle reprogramming induces the expression of several transcription regulators that coordinate changes in the expression of genes for lipid and glucose metabolism | Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression.
Long YC, Glund S, Garcia-Roves PM, Zierath JR. | 01/21/2010 |