| GluN3 subunit expression correlates with increased vulnerability of hippocampus and entorhinal cortex to neurodegeneration in a model of temporal lobe epilepsy. | GluN3 subunit expression correlates with increased vulnerability of hippocampus and entorhinal cortex to neurodegeneration in a model of temporal lobe epilepsy.
Beesley S, Sullenberger T, Lee C, Kumar SS., Free PMC Article | 06/11/2022 |
| The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription. | The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription.
Chen LF, Lyons MR, Liu F, Green MV, Hedrick NG, Williams AB, Narayanan A, Yasuda R, West AE., Free PMC Article | 01/9/2021 |
| Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors. | Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors.
Skrenkova K, Hemelikova K, Kolcheva M, Kortus S, Kaniakova M, Krausova B, Horak M., Free PMC Article | 10/24/2020 |
| N-methyl-D-aspartate receptor-mediated synaptic responses are induced by glycine in hippocampal CA1 neurons | Glycine induces bidirectional modifications in N-methyl-D-aspartate receptor-mediated synaptic responses in hippocampal CA1 neurons.
Zhang XY, Ji F, Wang N, Chen LL, Tian T, Lu W., Free PMC Article | 01/24/2015 |
| The hippocampus of fetuses gestated under light:dark photoperiod (12:12 LD) displayed daily oscillatory expression of the clock genes Bmal1 and Per2, clock-controlled genes Mtnr1b, Slc2a4, Nr3c1 and NMDA receptor subunits 1B-3A-3B | Gestational chronodisruption impairs hippocampal expression of NMDA receptor subunits Grin1b/Grin3a and spatial memory in the adult offspring.
Vilches N, Spichiger C, Mendez N, Abarzua-Catalan L, Galdames HA, Hazlerigg DG, Richter HG, Torres-Farfan C., Free PMC Article | 01/17/2015 |
| GluN3A protein expression in rat hippocampus and the prefrontal cortex was increased quickly after brain ischemia and remained at a high level for at least 24 h. After OGD, neurons with GluN3A subunit overexpression were more viable than wild-type neurons | The GluN3A subunit exerts a neuroprotective effect in brain ischemia and the hypoxia process.
Wang H, Yan H, Zhang S, Wei X, Zheng J, Li J., Free PMC Article | 06/21/2014 |
| Crystallization and structural analysis of the GluN1 and GluN3A ligand binding domains of the rat NMDA receptor subunits Grin1 and Grin3a. | Conformational analysis of NMDA receptor GluN1, GluN2, and GluN3 ligand-binding domains reveals subtype-specific characteristics.
Yao Y, Belcher J, Berger AJ, Mayer ML, Lau AY., Free PMC Article | 05/17/2014 |
| binding of GluN3A to GIT1 is regulated by synaptic activity, a response that might restrict the negative regulatory effects of GluN3A on actin signaling to inactive synapses. | GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling.
Fiuza M, González-González I, Pérez-Otaño I., Free PMC Article | 03/1/2014 |
| denitrosylation of nNOS induced by calcium ion influx is a NMDAR-dependent process during the early stage of ischemia/reperfusion, which is majorly mediated by thioredoxin-1 (Trx1) system. | N-methyl-D-aspartate receptor-dependent denitrosylation of neuronal nitric oxide synthase increase the enzyme activity.
Qu ZW, Miao WY, Hu SQ, Li C, Zhuo XL, Zong YY, Wu YP, Zhang GY., Free PMC Article | 06/29/2013 |
| a model whereby NR3A negatively regulates the developmental stabilization of glutamate receptors involved in excitatory neurotransmission, synaptogenesis, and spine growth. | Genetic deletion of NR3A accelerates glutamatergic synapse maturation.
Henson MA, Larsen RS, Lawson SN, Pérez-Otaño I, Nakanishi N, Lipton SA, Philpot BD., Free PMC Article | 02/23/2013 |
| Co-expression of both NMDA receptor subunits NR3A and NR3B is required for the dominant negative properties of calcium mobilization into mitochondria. | Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-D-aspartate receptor channels into mitochondria.
Fukumori R, Takarada T, Nakamichi N, Kambe Y, Kawagoe H, Nakazato R, Yoneda Y. | 09/10/2011 |
| Our findings reveal the presence of functional NMDARs in axons and growth cones of young neurons, suggesting a role for these receptors in axonal guidance and synapse formation during neuronal development. | Functional NMDA receptors at axonal growth cones of young hippocampal neurons.
Wang PY, Petralia RS, Wang YX, Wenthold RJ, Brenowitz SD., Free PMC Article | 09/3/2011 |
| These results support the hypothesis that the CaMKII/NMDAR complex has switch-like properties that are important in the maintenance of synaptic strength. | Role of the CaMKII/NMDA receptor complex in the maintenance of synaptic strength.
Sanhueza M, Fernandez-Villalobos G, Stein IS, Kasumova G, Zhang P, Bayer KU, Otmakhov N, Hell JW, Lisman J., Free PMC Article | 09/3/2011 |
| Suggest that D-Ser may negatively regulate cellular differentiation through inhibiting NMDA receptors composed of NR1 and NR3A subunits in a manner related to Runx2 transcriptional activity in chondrocytes. | Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes.
Takarada T, Takahata Y, Iemata M, Hinoi E, Uno K, Hirai T, Yamamoto T, Yoneda Y. | 01/21/2010 |
| The NMDAR3A subunits exhibit developmental loss around the time of eye opening in rat suprachiasmatic nucleus. | Circadian and developmental regulation of N-methyl-d-aspartate-receptor 1 mRNA splice variants and N-methyl-d-aspartate-receptor 3 subunit expression within the rat suprachiasmatic nucleus.
Bendová Z, Sumová A, Mikkelsen JD. | 01/21/2010 |
| mutation of leucine 958, leucine 973 or histidine 974 or deletion of a spacer sequence of more than six amino acids between leucine 958 and histidine 974 disrupted the NR3A/PP2A interaction. | Molecular interaction of NMDA receptor subunit NR3A with protein phosphatase 2A.
Ma OK, Sucher NJ. | 01/21/2010 |
| NR3A modulates the NR1/NR3A receptor permeation pathway via a novel mechanism of forming a narrow constriction at the outer channel vestibule. | NR3A modulates the outer vestibule of the "NMDA" receptor channel.
Wada A, Takahashi H, Lipton SA, Chen HS., Free PMC Article | 01/21/2010 |
| the NR3A subunit is not a determinant of ethanol sensitivity in recombinant NMDA receptors | Effect of the NR3 subunit on ethanol inhibition of recombinant NMDA receptors.
Smothers CT, Woodward JJ. | 01/21/2010 |