| PA28alpha overexpressing female mice maintain exploratory behavior and capacity to prevent protein aggregation in hippocampus as they age. | PA28α overexpressing female mice maintain exploratory behavior and capacity to prevent protein aggregation in hippocampus as they age.
Adelöf J, Wiseman J, Zetterberg M, Hernebring M., Free PMC Article | 02/26/2022 |
| Overexpression of PA28alpha and concomitant upregulation of PA28beta protein reduces depressive-like behavior and enhances learning and memory in female mice. The overexpression of PA28alpha does not increase PA28alphabeta-dependent proteasome activity but could still be linked to its protective functions upon oxidative stress and proteinopathy. | PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity.
Adelöf J, Andersson M, Porritt M, Petersen A, Zetterberg M, Wiseman J, Hernebring M., Free PMC Article | 08/24/2019 |
| In mouse models of both genetic and dietary obesity, stimulation of proteasomal activity by exogenously expressing Nrf1 or by treatment with the proteasome activator PA28alpha in BAT resulted in improved insulin sensitivity. In conclusion, Nrf1 emerges as a novel guardian of brown adipocyte function, providing increased proteometabolic quality control for adapting to cold or to obesity. | Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.
Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS., Free PMC Article | 05/11/2019 |
| PA28a overexpression quadruples the number of surviving photoreceptors in the inferior retina of mice with inherited retinal degeneration. | Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration.
Lobanova ES, Finkelstein S, Li J, Travis AM, Hao Y, Klingeborn M, Skiba NP, Deshaies RJ, Arshavsky VY., Free PMC Article | 12/22/2018 |
| Study clarifies the subunit composition and arrangement of PA28ab and provides key insights into the assembly of an asymmetric complex from two highly homologous subunits. Differential scanning fluorimetry experiments and activity assays classify PA28alpha4beta3 as most stable and most active, indicating that this assembly might represent the physiologically relevant species. | The Mammalian Proteasome Activator PA28 Forms an Asymmetric α(4)β(3) Complex.
Huber EM, Groll M. | 03/24/2018 |
| Inhibiting accumulation of PA28alpha using microRNA counteracted the removal of damaged proteins demonstrating that PA28alphabeta has a role required for resetting the levels of protein damage at the transition from self-renewal to cell differentiation. | Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28.
Hernebring M, Fredriksson Å, Liljevald M, Cvijovic M, Norrman K, Wiseman J, Semb H, Nyström T., Free PMC Article | 11/16/2013 |
| this study performed biophysical and biochemical characterization of the structure and function of the PA28 hetero-oligomer. | Spatial arrangement and functional role of α subunits of proteasome activator PA28 in hetero-oligomeric form.
Sugiyama M, Sahashi H, Kurimoto E, Takata S, Yagi H, Kanai K, Sakata E, Minami Y, Tanaka K, Kato K. | 09/21/2013 |
| Nrf2-dependent induction of proteasome and Pa28alphabeta regulator are required for adaptation to oxidative stress. | Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress.
Pickering AM, Linder RA, Zhang H, Forman HJ, Davies KJA., Free PMC Article | 05/19/2012 |
| demonstrate that PA28 and the proteasome immunosubunits use fundamentally different mechanisms to enhance the supply of MHC class I-binding peptides | PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo.
de Graaf N, van Helden MJ, Textoris-Taube K, Chiba T, Topham DJ, Kloetzel PM, Zaiss DM, Sijts AJ., Free PMC Article | 06/4/2011 |
| PA28alphaOE is sufficient to up-regulate 11S proteasomes, enhance proteasome-mediated removal of misfolded and oxidized proteins, and protect against oxidative stress in cardiomyocytes | Enhancement of proteasome function by PA28α overexpression protects against oxidative stress.
Li J, Powell SR, Wang X., Free PMC Article | 04/30/2011 |
| PA28-associated proteasome preferentially digested within epitopic sequences of K(d), although correct C-terminal flankings were removed | Allele-selective effect of PA28 in MHC class I antigen processing.
Yamano T, Sugahara H, Mizukami S, Murata S, Chiba T, Tanaka K, Yui K, Udono H. | 01/21/2010 |
| In immature dendritic cells, the assembly of PA28 alpha beta complexes appears to be limited by the low expression of PA28 beta, whereas PA28 alpha expression is already high. | Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells.
Ossendorp F, Fu N, Camps M, Granucci F, Gobin SJ, van den Elsen PJ, Schuurhuis D, Adema GJ, Lipford GB, Chiba T, Sijts A, Kloetzel PM, Ricciardi-Castagnoli P, Melief CJ. | 01/21/2010 |
| the processing of antigens is regulated by two distinct pathways, one requiring PA28 and the other hsp90 | Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing.
Yamano T, Murata S, Shimbara N, Tanaka N, Chiba T, Tanaka K, Yui K, Udono H., Free PMC Article | 01/21/2010 |