| EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2. | EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2.
Wang B, Jin Y, Liu J, Liu Q, Shen Y, Zuo S, Yu Y., Free PMC Article | 08/22/2023 |
| Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair. | Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair.
Feigenson M, Jonason JH, Shen J, Loiselle AE, Awad HA, O'Keefe RJ., Free PMC Article | 11/21/2020 |
| regulates renal aquaporins and sodium transporters, attenuates AVP-water transport and inhibits sodium transport in the mouse collecting duct | PGE(2) EP(1) receptor inhibits vasopressin-dependent water reabsorption and sodium transport in mouse collecting duct.
Nasrallah R, Zimpelmann J, Eckert D, Ghossein J, Geddes S, Beique JC, Thibodeau JF, Kennedy CRJ, Burns KD, Hébert RL. | 02/9/2019 |
| Loss of EP1 results in inactivation of Hif1alpha, increased oxygen consumption rate and thus increased osteoblast differentiation. | PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism.
Feigenson M, Eliseev RA, Jonason JH, Mills BN, O'Keefe RJ., Free PMC Article | 01/6/2018 |
| PGE2 serves as a central regulator of the Ren-1c gene in the principal cells of the kidney collecting ducts via the PKC/cAMP/CREB pathway. | PGE(2) upregulates renin through E-prostanoid receptor 1 via PKC/cAMP/CREB pathway in M-1 cells.
Gonzalez AA, Salinas-Parra N, Leach D, Navar LG, Prieto MC., Free PMC Article | 10/24/2017 |
| Our study identifies the EP1 signaling pathway as an important link between neuroinflammation and MMP-mediated BBB breakdown in ischemic stroke. | Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke.
Frankowski JC, DeMars KM, Ahmad AS, Hawkins KE, Yang C, Leclerc JL, Doré S, Candelario-Jalil E., Free PMC Article | 10/22/2016 |
| EP1-/- mice maintain increased bone mineral density and stronger cortical and trabecular bone biomechanical properties with aging. The EP1 receptor acts to inhibit bone marrow osteoprogenitor cell differentiation and mineralization. | Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength.
Zhang M, Feigenson M, Sheu TJ, Awad HA, Schwarz EM, Jonason JH, Loiselle AE, O'Keefe RJ., Free PMC Article | 10/3/2015 |
| Results indicate that EP1 receptor activation during seizures, through a protein kinase C pathway, increases probability of kainic acid induced status epilepticus, and independently promotes hippocampal neurodegeneration and a broad inflammatory response | The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus.
Rojas A, Gueorguieva P, Lelutiu N, Quan Y, Shaw R, Dingledine R., Free PMC Article | 04/25/2015 |
| The EP1 receptor facilitates the actions of angiotensin II, thereby suggesting that targeting of both the renin-angiotensin system and the EP1 receptor could be beneficial in diabetic nephropathy. | PTGER1 deletion attenuates renal injury in diabetic mouse models.
Thibodeau JF, Nasrallah R, Carter A, He Y, Touyz R, Hébert RL, Kennedy CRJ. | 07/5/2014 |
| Propose a mechanism whereby ANG II increases COX-1-derived PGE2 through the AT1R/PLA2 pathway, which promotes ROS production by EP1R/Nox2 signaling in the subfornical organ. | COX-1-derived PGE2 and PGE2 type 1 receptors are vital for angiotensin II-induced formation of reactive oxygen species and Ca(2+) influx in the subfornical organ.
Wang G, Sarkar P, Peterson JR, Anrather J, Pierce JP, Moore JM, Feng J, Zhou P, Milner TA, Pickel VM, Iadecola C, Davisson RL., Free PMC Article | 01/11/2014 |
| dietary administration and direct injection of the EP1 receptor-specific antagonist, ONO-8713, effectively reduced the growth of established CT26 tumors in BALB/c mice | Targeting the EP1 receptor reduces Fas ligand expression and increases the antitumor immune response in an in vivo model of colon cancer.
O'Callaghan G, Ryan A, Neary P, O'Mahony C, Shanahan F, Houston A. | 08/31/2013 |
| EP1 deletion protects mice from asymmetrical Parkinsonism. The PGE2 EP1 receptor is implicated in 6-OHDA-induced Parkinsonism. | PGE2 EP1 receptor deletion attenuates 6-OHDA-induced Parkinsonism in mice: old switch, new target.
Ahmad AS, Maruyama T, Narumiya S, Doré S., Free PMC Article | 08/31/2013 |
| Data suggest that EP1 receptor blockade may be a viable target for antihypertensive therapy. | EP1 disruption attenuates end-organ damage in a mouse model of hypertension.
Bartlett CS, Boyd KL, Harris RC, Zent R, Breyer RM., Free PMC Article | 01/12/2013 |
| data suggest that the tumor promoting/progressing effects of EP1 require the PGE2 synthesized by COX-2 | The EP1 receptor for prostaglandin E2 promotes the development and progression of malignant murine skin tumors.
Surh I, Rundhaug JE, Pavone A, Mikulec C, Abel E, Simper M, Fischer SM., Free PMC Article | 08/18/2012 |
| Peripheral EP1 receptors contribute significantly to inflammation induced heat pain sensitization while evidence for a contribution to central sensitization was not obtained. | Contribution of peripheral versus central EP1 prostaglandin receptors to inflammatory pain.
Johansson T, Narumiya S, Zeilhofer HU. | 08/20/2011 |
| Upregulation of the EP1 receptor for prostaglandin E2 promotes skin tumor progression. | Upregulation of the EP1 receptor for prostaglandin E2 promotes skin tumor progression.
Surh I, Rundhaug J, Pavone A, Mikulec C, Abel E, Fischer SM. | 07/23/2011 |
| study provides firm evidence for the direct action of the PGE2-EP1 signaling on dopaminergic regulation in the midbrain. This EP1 action may explain the impulsive behaviors of Ptger1-/- mice due to a hyperdopaminergic state. | Prostaglandin E receptor EP1 enhances GABA-mediated inhibition of dopaminergic neurons in the substantia nigra pars compacta and regulates dopamine level in the dorsal striatum.
Tanaka Y, Furuyashiki T, Momiyama T, Namba H, Mizoguchi A, Mitsumori T, Kayahara T, Shichi H, Kimura K, Matsuoka T, Nawa H, Narumiya S. | 04/12/2010 |
| Activation of EP1 receptors increases arteriolar tone, which could contribute to the development of hypertension in the db/db mice. | Activation of prostaglandin E2 EP1 receptor increases arteriolar tone and blood pressure in mice with type 2 diabetes.
Rutkai I, Feher A, Erdei N, Henrion D, Papp Z, Edes I, Koller A, Kaley G, Bagi Z., Free PMC Article | 01/21/2010 |
| These data strongly implicate a role for HIF-1alpha in hypoxia-induced EP1 expression | HIF-1alpha regulates hypoxia-induced EP1 expression in osteoblastic cells.
Genetos DC, Lee CM, Wong A, Yellowley CE., Free PMC Article | 01/21/2010 |
| prostaglandin E2 signaling via either EP1 or EP2 is largely to completely necessary for Toll-like receptor 4-dependent depletion of inttermediate progenitor cells from the hippocampal subgranular zone | Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2.
Keene CD, Chang R, Stephen C, Nivison M, Nutt SE, Look A, Breyer RM, Horner PJ, Hevner R, Montine TJ., Free PMC Article | 01/21/2010 |
| In urothelium, EP1 receptor may be important for reflex voiding in pathological conditions since it is present in the urothelium and is involved in the afferent limb. | Urothelium EP1 receptor facilitates the micturition reflex in mice.
Wang X, Momota Y, Yanase H, Narumiya S, Maruyama T, Kawatani M. | 01/21/2010 |
| the prostanoid EP1 receptor plays a significant role in regulating CBF and neuronal cell death. | Effects of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice.
Saleem S, Li RC, Wei G, Doré S., Free PMC Article | 01/21/2010 |
| PGE2 produced by dendritic cells in the lymph nodes acts on EP1 in naive T cells to promote Th1 differentiation. | Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1.
Nagamachi M, Sakata D, Kabashima K, Furuyashiki T, Murata T, Segi-Nishida E, Soontrapa K, Matsuoka T, Miyachi Y, Narumiya S., Free PMC Article | 01/21/2010 |
| support the possibility of targeting the EP1 receptor for antihypertensive therapy | Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.
Guan Y, Zhang Y, Wu J, Qi Z, Yang G, Dou D, Gao Y, Chen L, Zhang X, Davis LS, Wei M, Fan X, Carmosino M, Hao C, Imig JD, Breyer RM, Breyer MD., Free PMC Article | 01/21/2010 |
| prostaglandin E(2) acts through EP1 to control impulsive behavior under stress | Prostaglandin E receptor EP1 controls impulsive behavior under stress.
Matsuoka Y, Furuyashiki T, Yamada K, Nagai T, Bito H, Tanaka Y, Kitaoka S, Ushikubi F, Nabeshima T, Narumiya S., Free PMC Article | 01/21/2010 |