| Female Type 1 Diabetic Akita Mice Demonstrate Increased Bladder Contractility via FP Receptor Activation due to NLRP3-Mediated Inflammation. | Female Type 1 Diabetic Akita Mice Demonstrate Increased Bladder Contractility via FP Receptor Activation due to NLRP3-Mediated Inflammation.
Odom MR, Hughes FM Jr, Pope N, Jin H, Purves JT., | 05/9/2024 |
| PGF2alpha-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway. | PGF2α-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway.
Hu BA, Sai WW, Yuan J, Lan HT, Qi J, Wang D, Zhang W, Wang ZH, Zhong M, Shang YY., Free PMC Article | 03/12/2022 |
| Contribution of FP receptors in M1 macrophage polarization via IL-10-regulated nuclear translocation of NF-kappaB p65. | Contribution of FP receptors in M1 macrophage polarization via IL-10-regulated nuclear translocation of NF-κB p65.
Maehara T, Fujimori K. | 10/31/2020 |
| STC-1 is a downstream effector molecule in latanoprost signaling that is independent of the F2a receptor, equivalent and non-additive in the early intraocular pressure response in wild-type mice | Stanniocalcin-1 (STC-1), a downstream effector molecule in latanoprost signaling, acts independent of the FP receptor for intraocular pressure reduction.
Roddy GW, Rinkoski TA, Monson KJ, Chowdhury UR, Fautsch MP., Free PMC Article | 08/12/2020 |
| PGF2alpha potentiates platelet aggregation in vitro via EP3 receptor and thromboxane A2 receptor, but not PGF2a receptor | Prostaglandin F2α Facilitates Platelet Activation by Acting on Prostaglandin E2 Receptor Subtype EP3 and Thromboxane A2 Receptor TP in Mice.
Kashiwagi H, Yuhki KI, Imamichi Y, Kojima F, Kumei S, Tasaki Y, Narumiya S, Ushikubi F. | 03/14/2020 |
| FP receptor may have an important naive physiological role in the eye. | Contribution of prostanoid FP receptor and prostaglandins in transient inflammatory ocular hypertension.
Yamagishi-Kimura R, Honjo M, Aihara M., Free PMC Article | 10/19/2019 |
| Data, including data from studies using transgenic mice, suggest that signaling via prostaglandin-F2alpha/Ptgfr and Camk2g/p38/Foxo1 MAP kinase/calcium pathways are involved in regulation of hepatic gluconeogenesis in both obesity and fasting. (Ptgfr = prostaglandin F2alpha receptor; Camk2g = calcium-calmodulin-dependent protein kinase type 2 gamma; p38 = p38 MAP kinase; Foxo1 = forkhead box transcription factor O1) | Prostaglandin F(2α) Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.
Wang Y, Yan S, Xiao B, Zuo S, Zhang Q, Chen G, Yu Y, Chen D, Liu Q, Liu Y, Shen Y, Yu Y. | 09/8/2018 |
| Silencing of the FP receptor exerts a protective effect on diabetes-induced vascular remodeling | Prostaglandin F2α receptor silencing attenuates vascular remodeling in rats with type 2 diabetes.
Li Y, Han L, Ding WY, Ti Y, Li YH, Tang MX, Wang ZH, Zhang Y, Zhang W, Zhong M. | 04/23/2016 |
| Prostaglandin F-receptor antagonist AS604872 exacerbates vascular inflammation in hypertensive animals, facilitating intracranial aneurysm formation and aortic dissection. | Exacerbation of intracranial aneurysm and aortic dissection in hypertensive rat treated with the prostaglandin F-receptor antagonist AS604872.
Fukuda M, Aoki T, Manabe T, Maekawa A, Shirakawa T, Kataoka H, Takagi Y, Miyamoto S, Narumiya S. | 10/24/2015 |
| Data suggest that expression of Fabp4 (fatty acid binding protein 4) in preadipocytes is up-regulated by arachidonic acid during adipogenesis; this up-regulation appears mediated by prostaglandin F2alpha/FP (prostaglandin F2alpha receptor) signaling. | Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential.
Nikolopoulou E, Papacleovoulou G, Jean-Alphonse F, Grimaldi G, Parker MG, Hanyaloglu AC, Christian M., Free PMC Article | 10/24/2015 |
| it should be clarified as to which EP and/or FP receptor signals are physiologically essential for myometrial contraction and successful parturition. | Roles of prostaglandin receptors in female reproduction.
Sugimoto Y, Inazumi T, Tsuchiya S. | 10/3/2015 |
| These data suggest that during cuprizone-induced demyelination, PGF2alpha/FP receptor signaling contributes to glial activation, neuroinflammation, and demyelination, resulting in motor dysfunction | Prostaglandin F2α FP receptor inhibitor reduces demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model.
Iwasa K, Yamamoto S, Takahashi M, Suzuki S, Yagishita S, Awaji T, Maruyama K, Yoshikawa K. | 07/25/2015 |
| the role of prostaglandin F2alpha receptor (FP) signaling as a regulator of chondrocyte differentiation, was examined. | Prostaglandin F2α receptor (FP) signaling regulates Bmp signaling and promotes chondrocyte differentiation.
Kim J, Shim M., Free PMC Article | 04/25/2015 |
| Low COX-2 activity and the resulting deficiency of PGF2alpha cause increased seizure susceptibility in the immature brain. | Seizure susceptibility in immature brain due to lack of COX-2-induced PGF2α.
Chung JI, Kim AY, Lee SH, Baik EJ. | 12/14/2013 |
| The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma. | The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma.
Akiyama K, Ohga N, Maishi N, Hida Y, Kitayama K, Kawamoto T, Osawa T, Suzuki Y, Shinohara N, Nonomura K, Shindoh M, Hida K. | 08/3/2013 |
| Relatively selective localization of prostamide/PGF synthase suggests that myelin sheaths of the CNS may serve as the sites for producing prostamide F(alpha) and/or PGF(alpha), which may contribute to the formation and maintenance of central myelin. | Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system.
Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A. | 04/16/2011 |
| This study suggested that the PGF(2alpha) FP receptor significantly enhances cerebral ischemic and excitotoxic brain injury. | PGF(2alpha) FP receptor contributes to brain damage following transient focal brain ischemia.
Saleem S, Ahmad AS, Maruyama T, Narumiya S, Doré S., Free PMC Article | 02/1/2010 |
| The alphabeta-methylene ATP-evoked allodynia is mediated by the FP receptor, possibly via the functional coupling between the activation of P2X(2/3) receptors on the central terminal of capsaicin-insensitive fibers and FP receptors on spinal neurons. | Involvement of prostaglandin F 2 alpha receptor in ATP-induced mechanical allodynia.
Kunori S, Matsumura S, Mabuchi T, Tatsumi S, Sugimoto Y, Minami T, Ito S. | 01/21/2010 |
| pain sensitivity was increased in prostaglandin F receptor mutant mice | Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice.
Popp L, Häussler A, Olliges A, Nüsing R, Narumiya S, Geisslinger G, Tegeder I. | 01/21/2010 |
| The prostaglandin F(2alpha) receptor and progesterone withdrawal are a necessary part of the final common pathway for ripening of the cervix and the process of parturition. | Parturition and recruitment of macrophages in cervix of mice lacking the prostaglandin F receptor.
Yellon SM, Ebner CA, Sugimoto Y., Free PMC Article | 01/21/2010 |
| These results suggest that oxytocin has potentials to induce strong myometrial contractions in uterus with low expression levels of OTR and luteolysis in ovary, which enabled FP knockout females to undergo successful delivery. | Infusion of oxytocin induces successful delivery in prostanoid FP-receptor-deficient mice.
Kawamata M, Yoshida M, Sugimoto Y, Kimura T, Tonomura Y, Takayanagi Y, Yanagisawa T, Nishimori K. | 01/21/2010 |
| prostaglandin F synthase and prostaglandin F(2alpha )receptor are involved in the control of testosterone release from Leydig cells | Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells.
Suzuki-Yamamoto T, Sugimoto Y, Ichikawa A, Ishimura K. | 01/21/2010 |
| an important role for the FP receptor regulating water and solute transport in these segments of the nephron | Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract.
Saito O, Guan Y, Qi Z, Davis LS, Kömhoff M, Sugimoto Y, Narumiya S, Breyer RM, Breyer MD. | 01/21/2010 |
| uteroglobin plays important roles in maintaining homeostasis in organs that are vulnerable to inadvertent stimulation of FP-mediated inflammatory response by inhibiting the prostaglandin F2alpha receptor | Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators.
Mandal AK, Ray R, Zhang Z, Chowdhury B, Pattabiraman N, Mukherjee AB. | 01/21/2010 |
| The rabbit prostaglandin F receptor (FP) couples to the inhibitory G protein, Gi, to inhibit vasopressin action in the cortical collecting duct. | Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct.
Hébert RL, Carmosino M, Saito O, Yang G, Jackson CA, Qi Z, Breyer RM, Natarajan C, Hata AN, Zhang Y, Guan Y, Breyer MD. | 01/17/2006 |