| Intermittent mechanical loading on mouse tibia accelerates longitudinal bone growth by inducing PTHrP expression in the female tibial growth plate. | Intermittent mechanical loading on mouse tibia accelerates longitudinal bone growth by inducing PTHrP expression in the female tibial growth plate.
McGarry S, Kover K, Heruth DP, Dallas M, Jin X, Wu S, De Luca F., Free PMC Article | 08/2/2024 |
| A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2. | A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2.
Tsutsumi-Arai C, Arai Y, Tran A, Salinas M, Nakai Y, Orikasa S, Ono W, Ono N., Free PMC Article | 01/3/2024 |
| CaSR modulates proliferation of the superficial zone cells in temporomandibular joint cartilage via the PTHrP nuclear localization sequence. | CaSR modulates proliferation of the superficial zone cells in temporomandibular joint cartilage via the PTHrP nuclear localization sequence.
Zhou P, Yang H, Zhang M, Liu J, Yu J, Yu S, Liu Q, Zhang Y, Xie M, Xu X, Liu J, Wang M. | 08/31/2023 |
| The nuclear localization sequence and C-terminus of parathyroid hormone-related protein regulate normal pancreatic islet development and function. | The nuclear localization sequence and C-terminus of parathyroid hormone-related protein regulate normal pancreatic islet development and function.
Max-Harry IM, Hashmi WJ, List BP, Kantake N, Corbin KL, Toribio RE, Nunemaker CS, Rosol TJ., Free PMC Article | 06/16/2023 |
| Cranial Base Synchondrosis Lacks PTHrP-Expressing Column-Forming Chondrocytes. | Cranial Base Synchondrosis Lacks PTHrP-Expressing Column-Forming Chondrocytes.
Hallett SA, Zhou A, Herzog C, Arbiv A, Ono W, Ono N., Free PMC Article | 08/6/2022 |
| PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development. | PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development.
Grinman DY, Boras-Granic K, Takyar FM, Dann P, Hens JR, Marmol C, Lee J, Choi J, Chodosh LA, Sola MEG, Wysolmerski JJ., Free PMC Article | 05/14/2022 |
| PTHrP promotes development of mouse preimplantation embryos through the AKT/cyclin D1 pathway and nuclear translocation of HDAC4. | PTHrP promotes development of mouse preimplantation embryos through the AKT/cyclin D1 pathway and nuclear translocation of HDAC4.
Li YY, Guo L, Li H, Lei WL, Fan LH, Ouyang YC, Hou Y, Wang ZB, Sun QY, Lu SS, Han Z. | 12/4/2021 |
| Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment. | Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment.
Hallett SA, Matsushita Y, Ono W, Sakagami N, Mizuhashi K, Tokavanich N, Nagata M, Zhou A, Hirai T, Kronenberg HM, Ono N., Free PMC Article | 11/13/2021 |
| Dmp1Cre-directed knockdown of parathyroid hormone-related protein (PTHrP) in murine decidua is associated with a life-long increase in bone mass, width, and strength in male progeny. | Dmp1Cre-directed knockdown of parathyroid hormone-related protein (PTHrP) in murine decidua is associated with a life-long increase in bone mass, width, and strength in male progeny.
Ansari N, Isojima T, Crimeen-Irwin B, Poulton IJ, McGregor NE, Ho PWM, Forwood MR, Kovacs CS, Dimitriadis E, Gooi JH, Martin TJ, Sims NA. | 10/30/2021 |
| Effect of Parathyroid Hormone on Intestinal Mucosal Sodium Dependent Phosphorus Transporter. | Effect of Parathyroid Hormone on Intestinal Mucosal Sodium Dependent Phosphorus Transporter.
Guo W, Wang LY, Han X, Liu WH. | 10/23/2021 |
| Intrinsic electrophysiological properties predict variability in morphology and connectivity among striatal Parvalbumin-expressing Pthlh-cells. | Intrinsic electrophysiological properties predict variability in morphology and connectivity among striatal Parvalbumin-expressing Pthlh-cells.
Bengtsson Gonzales C, Hunt S, Munoz-Manchado AB, McBain CJ, Hjerling-Leffler J., Free PMC Article | 01/2/2021 |
| Serotonin stimulated parathyroid hormone related protein induction in the mammary epithelia by transglutaminase-dependent serotonylation. | Serotonin stimulated parathyroid hormone related protein induction in the mammary epithelia by transglutaminase-dependent serotonylation.
Sheftel CM, Hernandez LL., Free PMC Article | 12/26/2020 |
| PTHrP inhibits chondrocyte hypertrophy and subsequent bone formation in vivo by allowing HDAC4 and HDAC5 to block the Mef2/Runx2 signaling cascade. | PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy.
Nishimori S, Lai F, Shiraishi M, Kobayashi T, Kozhemyakina E, Yao TP, Lassar AB, Kronenberg HM., Free PMC Article | 06/6/2020 |
| osteocyte-derived full-length PTHrP acts through both PTHR1 receptor-mediated and receptor-independent actions in a paracrine/autocrine manner to stimulate bone formation and to modify adult cortical bone strength. | Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein.
Ansari N, Ho PW, Crimeen-Irwin B, Poulton IJ, Brunt AR, Forwood MR, Divieti Pajevic P, Gooi JH, Martin TJ, Sims NA. | 09/28/2019 |
| Chk2 deletion in Pthrp KI mice can somewhat rescue defects in osteoblastic bone formation and skeletal growth by enhancing endochondral bone formation and osteogenesis | DNA damage checkpoint pathway modulates the regulation of skeletal growth and osteoblastic bone formation by parathyroid hormone-related peptide.
Zhang Y, Chen G, Gu Z, Sun H, Karaplis A, Goltzman D, Miao D., Free PMC Article | 07/20/2019 |
| PTHrP has antinomic actions in glomerulonephritis, participating in both the proinflammatory condition and the healing process. | Parathyroid Hormone-Related Protein Contributes to Early Healing of Habu Snake Venom-Induced Glomerulonephritis in Mice.
Hochane M, Raison D, Coquard C, Béraud C, Danilin S, Bethry A, Massfelder T, Barthelmebs M. | 04/20/2019 |
| PTHrP expression is required for normal morphological development of the placenta. | PTHrP is essential for normal morphogenetic and functional development of the murine placenta.
Duval C, Dilworth MR, Tunster SJ, Kimber SJ, Glazier JD. | 06/30/2018 |
| ECM1 seems to be critical for PTHrP action in chondrogenesis, as blockage of ECM1 nearly abolishes PTHrP regulation of chondrocyte hypertrophy, and overexpression of ECM1 rescues disorganized growth plates of PTHrP-null mice; ECM1 and progranulin chondrogenic growth factor constitute an interaction network. | Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone-related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor.
Kong L, Zhao YP, Tian QY, Feng JQ, Kobayashi T, Merregaert J, Liu CJ., Free PMC Article | 08/26/2017 |
| PTHLH is a gastrin-regulated growth factor that might contribute to gastric epithelial cell homeostasis. | Gastrin induces parathyroid hormone-like hormone expression in gastric parietal cells.
Al Menhali A, Keeley TM, Demitrack ES, Samuelson LC., Free PMC Article | 08/12/2017 |
| The truncated PTHrP (1-84) led to abnormal subpopulations, impaired proliferation and increased apoptosis in the thymus, indicating that PTHrP is involved in the development of T cells, and the NLS and C-terminus part is necessary for the normal role of PTHrP in T-cell development. | Absence of PTHrP nuclear localization and C-terminus sequences leads to abnormal development of T cells.
Jia KZ, Jin SL, Yao C, Rong R, Wang C, Du P, Jiang WH, Huang XF, Hu QG, Miao DS, Hua ZC. | 08/12/2017 |
| PTHrP(1-36) significantly enhances beta cell regeneration through increased beta cell proliferation and beta cell mass after Partial Pancreatectomy | Parathyroid Hormone-Related Peptide (1-36) Enhances Beta Cell Regeneration and Increases Beta Cell Mass in a Mouse Model of Partial Pancreatectomy.
Mozar A, Lin H, Williams K, Chin C, Li R, Kondegowda NG, Stewart AF, Garcia-Ocaña A, Vasavada RC., Free PMC Article | 07/22/2017 |
| An accelerated hypertrophic differentiation caused by a disturbed Ihh-PTHrP signaling pathway may lead to a higher bone mineral density in the vertebral bodies of newborn Col IX -/- mice and, as a result, to the early onset of disc degeneration. | Absence of collagen IX accelerates hypertrophic differentiation in the embryonic mouse spine through a disturbance of the Ihh-PTHrP feedback loop.
Kamper M, Paulsson M, Zaucke F. | 06/3/2017 |
| Data show that parathyroid hormone-related protein (PTHrP) regulates gremlin levels in pancreatic acinar and stellate cells. | Parathyroid Hormone-Related Protein Interacts With the Transforming Growth Factor-β/Bone Morphogenetic Protein-2/Gremlin Signaling Pathway to Regulate Proinflammatory and Profibrotic Mediators in Pancreatic Acinar and Stellate Cells.
Bhatia V, Cao Y, Ko TC, Falzon M., Free PMC Article | 01/14/2017 |
| nuclear localization sequence and C-terminus play a critical role in preventing skin from premature ageing partially mediated by p27 | Deficiency of the parathyroid hormone-related peptide nuclear localization and carboxyl terminal sequences leads to premature skin ageing partially mediated by the upregulation of p27.
Jiang M, Chen G, Lu N, Zhang Y, Jin S, Karaplis A, Goltzman D, Miao D. | 10/29/2016 |
| the p27 pathway may function downstream in the action of PTHrP to regulate skeletal growth and development. | The p27 Pathway Modulates the Regulation of Skeletal Growth and Osteoblastic Bone Formation by Parathyroid Hormone-Related Peptide.
Zhu M, Zhang J, Dong Z, Zhang Y, Wang R, Karaplis A, Goltzman D, Miao D. | 09/10/2016 |