| Single-cell RNA-sequencing analysis reveals enhanced non-canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury. | Single-cell RNA-sequencing analysis reveals enhanced non-canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury.
Qiu X, Guo Y, Liu MF, Zhang B, Li J, Wei JF, Li M., Free PMC Article | 11/28/2023 |
| Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction. | Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction.
Li H, Xu L, Jiang W, Qiu X, Xu H, Zhu F, Hu Y, Liang S, Cai C, Qiu W, Lu Z, Cui Y, Tang C. | 10/5/2023 |
| The Combination of Quantitative Proteomics and Systems Genetics Analysis Reveals that PTN Is Associated with Sleep-Loss-Induced Cognitive Impairment. | The Combination of Quantitative Proteomics and Systems Genetics Analysis Reveals that PTN Is Associated with Sleep-Loss-Induced Cognitive Impairment.
Zhou Y, Li H, Liu X, Chi X, Gu Z, Cui B, Bergquist J, Wang B, Tian G, Yang C, Xu F, Mi J. | 09/20/2023 |
| Pleiotrophin drives a prometastatic immune niche in breast cancer. | Pleiotrophin drives a prometastatic immune niche in breast cancer.
Ganguly D, Schmidt MO, Coleman M, Ngo TC, Sorrelle N, Dominguez ATA, Murimwa GZ, Toombs JE, Lewis C, Fang YV, Valdes-Mora F, Gallego-Ortega D, Wellstein A, Brekken RA., Free PMC Article | 02/28/2023 |
| Clematichinenoside AR inhibits the pathology of rheumatoid arthritis by blocking the circPTN/miR-145-5p/FZD4 signal axis. | Clematichinenoside AR inhibits the pathology of rheumatoid arthritis by blocking the circPTN/miR-145-5p/FZD4 signal axis.
Wang X, Zhou D, Zhou W, Liu J, Xue Q, Huang Y, Cheng C, Wang Y, Chang J, Wang P, Miao C. | 12/10/2022 |
| Pleiotrophin Expression and Actions in Pancreatic beta-Cells. | Pleiotrophin Expression and Actions in Pancreatic β-Cells.
Sevillano J, Liang A, Strutt B, Hill TG, Szlapinski S, Ramos-Álvarez MP, Hill DJ., Free PMC Article | 04/30/2022 |
| Deletion of pleiotrophin impairs glucose tolerance and liver metabolism in pregnant mice: Moonlighting role of glycerol kinase. | Deletion of pleiotrophin impairs glucose tolerance and liver metabolism in pregnant mice: Moonlighting role of glycerol kinase.
Zapatería B, Sevillano J, Sánchez-Alonso MG, Limones M, Pizarro-Delgado J, Zuccaro A, Herradón G, Medina-Gómez G, Ramos-Álvarez MP. | 10/30/2021 |
| Pleiotrophin Deficiency Induces Browning of Periovarian Adipose Tissue and Protects against High-Fat Diet-Induced Hepatic Steatosis. | Pleiotrophin Deficiency Induces Browning of Periovarian Adipose Tissue and Protects against High-Fat Diet-Induced Hepatic Steatosis.
Zuccaro A, Zapatería B, Sánchez-Alonso MG, Haro M, Limones M, Terrados G, Izquierdo A, Corrales P, Medina-Gómez G, Herradón G, Sevillano J, Ramos-Álvarez MDP., Free PMC Article | 10/23/2021 |
| Mechanistically, PTN promoted chronic myelogenous leukemia stem cell survival and TKI resistance via induction of Jun and the unfolded protein response. | Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling.
Himburg HA, Roos M, Fang T, Zhang Y, Termini CM, Schlussel L, Kim M, Pang A, Kan J, Zhao L, Suh H, Sasine JP, Sapparapu G, Bowers PM, Schiller G, Chute JP., Free PMC Article | 07/25/2020 |
| Hmgb3 may play an important role during embryo implantation and decidualization. Pleiotropin is a downstream target of Hmgb3 in the differentiation of uterine stromal cells. | Hmgb3 Induces the Differentiation of Uterine Stromal Cells Through Targeting Ptn.
Wang K, Yin YH, Yang ZQ, Yu HF, Wang YS, Guo B, Yue ZP. | 04/18/2020 |
| The Pleiotrophin (PTN) expression is increased in bone marrow endothelial cells (BMECs), and PTN(+) ECs are more frequent in the niche. | Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration.
Himburg HA, Termini CM, Schlussel L, Kan J, Li M, Zhao L, Fang T, Sasine JP, Chang VY, Chute JP., Free PMC Article | 10/5/2019 |
| Adult hippocampal neural stem cells continuously supply pleiotrophin factor to newborn neurons. | Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN.
Tang C, Wang M, Wang P, Wang L, Wu Q, Guo W. | 08/24/2019 |
| Results reveal for the first time that pleiotrophin is a key player in preserving insulin sensitivity, driving the dynamics of adipose tissue lipid turnover and plasticity, and regulating energy metabolism and thermogenesis. | Pleiotrophin deletion alters glucose homeostasis, energy metabolism and brown fat thermogenic function in mice.
Sevillano J, Sánchez-Alonso MG, Zapatería B, Calderón M, Alcalá M, Limones M, Pita J, Gramage E, Vicente-Rodríguez M, Horrillo D, Medina-Gómez G, Obregón MJ, Viana M, Valladolid-Acebes I, Herradón G, Ramos-Álvarez MP. | 06/8/2019 |
| A new oncofetal lncRNA Ptn-dt is identified. | Genome-wide screening identifies oncofetal lncRNA Ptn-dt promoting the proliferation of hepatocellular carcinoma cells by regulating the Ptn receptor.
Huang JF, Jiang HY, Cai H, Liu Y, Zhu YQ, Lin SS, Hu TT, Wang TT, Yang WJ, Xiao B, Sun SH, Ma LY, Yin HR, Wang F. | 05/25/2019 |
| Molecular crosstalk between tumour-associated macrophages and glioma stem cells through PTN-PTPRZ1 paracrine signalling supports glioblastoma malignant growth. | Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth.
Shi Y, Ping YF, Zhou W, He ZC, Chen C, Bian BS, Zhang L, Chen L, Lan X, Zhang XC, Zhou K, Liu Q, Long H, Fu TW, Zhang XN, Cao MF, Huang Z, Fang X, Wang X, Feng H, Yao XH, Yu SC, Cui YH, Zhang X, Rich JN, Bao S, Bian XW., Free PMC Article | 11/10/2018 |
| Study demonstrates that regulation of astroglial responses to lipopolysaccharide administration are highly dependent on the levels of expression of pleiotrophin and midkine. | Endogenous pleiotrophin and midkine regulate LPS-induced glial responses.
Fernández-Calle R, Vicente-Rodríguez M, Gramage E, de la Torre-Ortiz C, Pérez-García C, Ramos MP, Herradón G. | 06/30/2018 |
| PTN expression in glioma cells is associated with chromosome 7 gain. PTN enhances PDGFB-induced gliomagenesis by stimulating proliferation of neural progenitor cells. | Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells.
Zhang L, Laaniste L, Jiang Y, Alafuzoff I, Uhrbom L, Dimberg A., Free PMC Article | 02/24/2018 |
| The data demonstrate that PTN overexpression in the brain blocks the conditioning effects of amphetamine and enhances the characteristic striatal dopaminergic denervation caused by this drug | Pleiotrophin overexpression regulates amphetamine-induced reward and striatal dopaminergic denervation without changing the expression of dopamine D1 and D2 receptors: Implications for neuroinflammation.
Vicente-Rodríguez M, Rojo Gonzalez L, Gramage E, Fernández-Calle R, Chen Y, Pérez-García C, Ferrer-Alcón M, Uribarri M, Bailey A, Herradón G. | 01/27/2018 |
| NK cells promote fetal development through the secretion of growth-promoting factors, pleiotrophin and osteoglycin. | Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z, Wei H. | 12/30/2017 |
| Ptn may play a vital role in the progesterone-induced decidualization pathway via C/EBPB-cyclic AMP-Hand2 signaling. | Ptn functions downstream of C/EBPβ to mediate the effects of cAMP on uterine stromal cell differentiation through targeting Hand2 in response to progesterone.
Yu HF, Tao R, Yang ZQ, Wang K, Yue ZP, Guo B. | 11/25/2017 |
| The results of this study suggested that regulation of the PTN signaling pathways may constitute new therapeutic opportunities particularly in those neurological disorders characterized by increased PTN cerebral levels and neuroinflammation. | Pleiotrophin regulates microglia-mediated neuroinflammation.
Fernández-Calle R, Vicente-Rodríguez M, Gramage E, Pita J, Pérez-García C, Ferrer-Alcón M, Uribarri M, Ramos MP, Herradón G., Free PMC Article | 10/14/2017 |
| these data indicate that PTN-PTPRZ-A signaling controls the timing of oligodendrocyte precursor cell differentiation in vivo, in which the CS moiety of PTPRZ receptors maintains them in a monomeric active state until its ligand binding. | Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.
Kuboyama K, Fujikawa A, Suzuki R, Tanga N, Noda M., Free PMC Article | 05/13/2017 |
| findings link pleiotrophin abundance in gliomas with survival in humans and mice, and show that pleiotrophin promotes glioma progression through increased VEGF deposition and vascular abnormalization. | Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.
Zhang L, Kundu S, Feenstra T, Li X, Jin C, Laaniste L, El Hassan TE, Ohlin KE, Yu D, Olofsson T, Olsson AK, Pontén F, Magnusson PU, Nilsson KF, Essand M, Smits A, Dieterich LC, Dimberg A. | 10/1/2016 |
| antagonizes Brd2 promoting cell differentiation associated with the neural tube: spinal cord neurogenesis and neural crest migration | Pleiotrophin antagonizes Brd2 during neuronal differentiation.
Garcia-Gutierrez P, Juarez-Vicente F, Wolgemuth DJ, Garcia-Dominguez M., Free PMC Article | 05/16/2015 |
| PTN-mediated hematopoietic regeneration occurs in a RAS-dependent manner. | Pleiotrophin mediates hematopoietic regeneration via activation of RAS.
Himburg HA, Yan X, Doan PL, Quarmyne M, Micewicz E, McBride W, Chao NJ, Slamon DJ, Chute JP., Free PMC Article | 03/7/2015 |