| Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression. | Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression.
Lee J, Yurkovetskiy LA, Reiman D, Frommer L, Strong Z, Chang A, Kahaly GJ, Khan AA, Chervonsky AV., Free PMC Article | 10/11/2024 |
| PTPN22 through the regulation of Th17/Treg balance acts as a potential target for the treatment of Graves' disease. | PTPN22 through the regulation of Th17/Treg balance acts as a potential target for the treatment of Graves' disease.
Cai H, Chen S, Jiang Z, Chen L, Yang X. | 10/10/2024 |
| Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity. | Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity.
Orozco RC, Marquardt K, Pratumchai I, Shaikh AF, Mowen K, Domissy A, Teijaro JR, Sherman LA., Free PMC Article | 04/5/2024 |
| Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice. | Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice.
Li S, Luo Z, Su S, Wen L, Xian G, Zhao J, Xu X, Xu D, Zeng Q., Free PMC Article | 09/11/2023 |
| Protein tyrosine phosphatase PTPN22 negatively modulates platelet function and thrombus formation. | Protein tyrosine phosphatase PTPN22 negatively modulates platelet function and thrombus formation.
Wang X, Wei G, Ding Y, Gui X, Tong H, Xu X, Zhang S, Sun Z, Ju W, Li Y, Yao R, Wu Q, Lu Z, Fu C, Li Z, Zhang S, Gardiner EE, Andrews RK, Hu H, Zeng L, Xu K, Qiao J. | 09/17/2022 |
| Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation. | Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation.
James J, Chen Y, Hernandez CM, Forster F, Dagnell M, Cheng Q, Saei AA, Gharibi H, Lahore GF, Åstrand A, Malhotra R, Malissen B, Zubarev RA, Arnér ESJ, Holmdahl R., Free PMC Article | 05/28/2022 |
| Targeting Protein Tyrosine Phosphatase 22 Does Not Enhance the Efficacy of Chimeric Antigen Receptor T Cells in Solid Tumors. | Targeting Protein Tyrosine Phosphatase 22 Does Not Enhance the Efficacy of Chimeric Antigen Receptor T Cells in Solid Tumors.
Du X, Darcy PK, Wiede F, Tiganis T., Free PMC Article | 05/14/2022 |
| Mesenchymal Stem Cells Derived Extracellular Vesicles Alleviate Traumatic Hemorrhagic Shock Induced Hepatic Injury via IL-10/PTPN22-Mediated M2 Kupffer Cell Polarization. | Mesenchymal Stem Cells Derived Extracellular Vesicles Alleviate Traumatic Hemorrhagic Shock Induced Hepatic Injury via IL-10/PTPN22-Mediated M2 Kupffer Cell Polarization.
Zhang Y, Zhang X, Zhang H, Song P, Pan W, Xu P, Wang G, Hu P, Wang Z, Huang K, Zhang X, Wang H, Zhang J., Free PMC Article | 03/12/2022 |
| Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity. | Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity.
Orozco RC, Marquardt K, Mowen K, Sherman LA., Free PMC Article | 09/25/2021 |
| Ptpn22 Arg>Trp Polymorphism Improves Macrophage-Mediated Adipocyte Homeostasis. | Ptpn22 Arg>Trp Polymorphism Improves Macrophage-Mediated Adipocyte Homeostasis.
Li MH, Sun C, Sun YC, Niu YJ, Wu CH, Polychronakos C. | 08/7/2021 |
| Regulation of B cell homeostasis by Ptpn22 contributes to type 1 diabetes in NOD mice. | Regulation of B cell homeostasis by Ptpn22 contributes to type 1 diabetes in NOD mice.
Shi X, Shao F, Li Z, Kang L, Liu J, Kissler S, Zhou Z, Jia L, Zheng P. | 07/10/2021 |
| Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses. | Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses.
Purvis HA, Clarke F, Montgomery AB, Colas C, Bibby JA, Cornish GH, Dai X, Dudziak D, Rawlings DJ, Zamoyska R, Guermonprez P, Cope AP., Free PMC Article | 03/27/2021 |
| PTPN22 Acts in a Cell Intrinsic Manner to Restrict the Proliferation and Differentiation of T Cells Following Antibody Lymphodepletion. | PTPN22 Acts in a Cell Intrinsic Manner to Restrict the Proliferation and Differentiation of T Cells Following Antibody Lymphodepletion.
Knipper JA, Wright D, Cope AP, Malissen B, Zamoyska R., Free PMC Article | 03/6/2021 |
| Deletion of PTPN22 improves effector and memory CD8+ T cell responses to tumors. | Deletion of PTPN22 improves effector and memory CD8+ T cell responses to tumors.
Brownlie RJ, Wright D, Zamoyska R, Salmond RJ., Free PMC Article | 10/24/2020 |
| These results show that PTPN22 promotes intestinal inflammation in IL-10-deficient mice, suggesting that therapeutic targeting of PTPN22 might be beneficial in patients with IBD and mutations in IL-10 and IL-10R. | Experimental colitis in IL-10-deficient mice ameliorates in the absence of PTPN22.
Jofra T, Galvani G, Cosorich I, De Giorgi L, Annoni A, Vecchione A, Sorini C, Falcone M, Fousteri G., Free PMC Article | 05/9/2020 |
| Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis model. | Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis.
Spalinger MR, Schwarzfischer M, Hering L, Shawki A, Sayoc A, Santos A, Gottier C, Lang S, Bäbler K, Geirnaert A, Lacroix C, Leventhal GE, Dai X, Rawlings D, Chan AA, Rogler G, McCole DF, Scharl M. | 05/2/2020 |
| This indicates that presence of the PTPN22 variant affects intestinal inflammation by modulating the host's response to the intestinal microbiota. | Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner.
Spalinger MR, Schmidt TS, Schwarzfischer M, Hering L, Atrott K, Lang S, Gottier C, Geirnaert A, Lacroix C, Dai X, Rawlings DJ, Chan AC, von Mering C, Rogler G, Scharl M., Free PMC Article | 04/18/2020 |
| The data point to two related but distinct mechanisms by which PTPN22 regulates LFA-1 dependent signals to enhance Th1 development, highlighting how perturbations to PTPN22 function over time to regulate the balance of the immune response. | Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses.
Sanchez-Blanco C, Clarke F, Cornish GH, Depoil D, Thompson SJ, Dai X, Rawlings DJ, Dustin ML, Zamoyska R, Cope AP, Purvis HA., Free PMC Article | 10/5/2019 |
| The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases [Review]. | A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22.
Vang T, Nielsen J, Burn GL. | 09/21/2019 |
| these findings highlight PTPN22 as a novel regulator of dectin-1 signals, providing a link between genetically conferred perturbations of innate receptor signaling and the risk of autoimmune disease | Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice.
Purvis HA, Clarke F, Jordan CK, Blanco CS, Cornish GH, Dai X, Rawlings DJ, Zamoyska R, Cope AP., Free PMC Article | 11/10/2018 |
| PTPN22 role in CD8-positive t cells activation. | Resistance to TGFβ suppression and improved anti-tumor responses in CD8(+) T cells lacking PTPN22.
Brownlie RJ, Garcia C, Ravasz M, Zehn D, Salmond RJ, Zamoyska R., Free PMC Article | 09/22/2018 |
| This finding shows that autophagy and NLRP3 inflammasome activation are connected, and that PTPN22 plays a key role in the regulation of those 2 pathways. | PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.
Spalinger MR, Lang S, Gottier C, Dai X, Rawlings DJ, Chan AC, Rogler G, Scharl M., Free PMC Article | 05/26/2018 |
| Here we show that mice deficient in PTPN22 resist chronic viral infection with lymphocytic choriomeningitis virus clone 13. The numbers and function of viral-specific CD4 T lymphocytes is greatly enhanced, whereas expression of the IFNbeta-induced IL-2 repressor, cAMP-responsive element modulator is reduced. | PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection.
Maine CJ, Teijaro JR, Marquardt K, Sherman LA., Free PMC Article | 04/28/2018 |
| we have discovered that inactivation of Ptpn22 or Mll3 greatly accelerated PI3K-driven mammary tumorigenesis | Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation.
Zhang Z, Christin JR, Wang C, Ge K, Oktay MH, Guo W., Free PMC Article | 02/10/2018 |
| Our findings, for the first time, illustrate the indirect impact of the 619 Arg > Trp polymorphic PTPN22 on T cells activation, mediated by polymorphic effects on macrophages and indicate a possible role of PTPN22 in cytoskeleton re-arrangement. | The common, autoimmunity-predisposing 620Arg > Trp variant of PTPN22 modulates macrophage function and morphology.
Li M, Beauchemin H, Popovic N, Peterson A, d'Hennezel E, Piccirillo CA, Sun C, Polychronakos C. | 12/23/2017 |