| A direct interaction between RhoGDIalpha/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia. | A direct interaction between RhoGDIα/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia.
Zhang H, Lu F, Liu P, Qiu Z, Li J, Wang X, Xu H, Zhao Y, Li X, Wang H, Lu D, Qi R. | 09/8/2023 |
| The Rho guanine dissociation inhibitor alpha inhibits skeletal muscle Rac1 activity and insulin action. | The Rho guanine dissociation inhibitor α inhibits skeletal muscle Rac1 activity and insulin action.
Møller LLV, Ali MS, Davey J, Raun SH, Andersen NR, Long JZ, Qian H, Jeppesen JF, Henriquez-Olguin C, Frank E, Jensen TE, Højlund K, Wojtaszewski JFP, Nielsen J, Chiu TT, Jedrychowski MP, Gregorevic P, Klip A, Richter EA, Sylow L., Free PMC Article | 07/3/2023 |
| RhoGDIalpha regulates spermatogenesis through Rac1/cofilin/F-actin signaling. | RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling.
Zhu H, Wen Z, Zhang A, Liu D, Wang H, Cheng Y, Yang X, Xiao Y, Li J, Sun D, Wu B, Gao J., Free PMC Article | 02/27/2023 |
| The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules. | The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules.
Agbaegbu Iweka C, Hussein RK, Yu P, Katagiri Y, Geller HM., Free PMC Article | 06/26/2021 |
| Rho GDP dissociation inhibitor alpha silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling | Rho GDP dissociation inhibitor α silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling.
Wei Z, Xu H, Zhang Y, Yi X, Yang X, Chen Y, Mao N, Li S, Xu D, Li S, Zhang H, Li D, Zhang G, Zhang B, Jin F, Gao X, Cai W, Zhang L, Wang R, Yang F. | 07/4/2020 |
| GDIalpha has a critical role in suppressing Rac1 activity in mature podocytes | Disease-causing mutations of RhoGDIα induce Rac1 hyperactivation in podocytes.
Auguste D, Maier M, Baldwin C, Aoudjit L, Robins R, Gupta IR, Takano T., Free PMC Article | 12/2/2017 |
| The siRNA-mediated suppression of expression of alphaGDI especially affected vesicle dynamics. | Impaired αGDI Function in the X-Linked Intellectual Disability: The Impact on Astroglia Vesicle Dynamics.
Potokar M, Jorgačevski J, Lacovich V, Kreft M, Vardjan N, Bianchi V, D'Adamo P, Zorec R. | 07/1/2017 |
| Integrin beta 8 and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 signaling by controlling the subcellular localization and phosphorylation status of Rho GDP dissociation inhibitor 1. | Protein tyrosine phosphatase-PEST and β8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells.
Lee HS, Cheerathodi M, Chaki SP, Reyes SB, Zheng Y, Lu Z, Paidassi H, DerMardirossian C, Lacy-Hulbert A, Rivera GM, McCarty JH., Free PMC Article | 06/6/2015 |
| RhoGDalpha controls ENaC expression and activity via Rac1. | Role of Rho GDP dissociation inhibitor α in control of epithelial sodium channel (ENaC)-mediated sodium reabsorption.
Pavlov TS, Levchenko V, Staruschenko A., Free PMC Article | 02/7/2015 |
| Results identify a critical role for 14-3-3tau in promoting breast cancer metastasis, in part through binding to and inhibition of RhoGDIalpha, a negative regulator of Rho GTPases and a metastasis suppressor. | 14-3-3τ promotes breast cancer invasion and metastasis by inhibiting RhoGDIα.
Xiao Y, Lin VY, Ke S, Lin GE, Lin FT, Lin WC., Free PMC Article | 12/20/2014 |
| the association of RhoGDIalpha with TROY contributed to TROY-dependent RhoA activation and neurite outgrowth inhibition after Nogo-66 stimulation. | TROY interacts with Rho guanine nucleotide dissociation inhibitor α (RhoGDIα) to mediate Nogo-induced inhibition of neurite outgrowth.
Lu Y, Liu X, Zhou J, Huang A, Zhou J, He C., Free PMC Article | 02/8/2014 |
| Data found that CCK-induced PKCalpha phosphorylation on RhoGDI1 at Ser96 releases RhoA and Rac1 from RhoGDI1 to facilitate Rho GTPases signaling. | Cholecystokinin-mediated RhoGDI phosphorylation via PKCα promotes both RhoA and Rac1 signaling.
Sabbatini ME, Williams JA., Free PMC Article | 01/18/2014 |
| we demonstrated the regulation of targeting/accumulation of the RhoGDIalpha-Rac1 complex to phagosomes | Negative charges in the flexible N-terminal domain of Rho GDP-dissociation inhibitors (RhoGDIs) regulate the targeting of the RhoGDI-Rac1 complex to membranes.
Ueyama T, Son J, Kobayashi T, Hamada T, Nakamura T, Sakaguchi H, Shirafuji T, Saito N. | 11/16/2013 |
| how the beta cell utilizes RhoGDI for differential Cdc42 and Rac1 cycling | Differential phosphorylation of RhoGDI mediates the distinct cycling of Cdc42 and Rac1 to regulate second-phase insulin secretion.
Wang Z, Thurmond DC., Free PMC Article | 03/29/2010 |
| Morphological analysis of Rho GDP Dissociation Inhibitor (-/-) renal mesangial cells reveals a decrease in cell spreading compared to wild-type cells and a decreased ability to proliferate and survive. | Morphological and proliferative abnormalities in renal mesangial cells lacking RhoGDI.
Bielek H, Anselmo A, Dermardirossian C., Free PMC Article | 02/22/2010 |
| Fibroblast growth factor 2-induced Rac1 activation depends on the suppression of RhoG by a previously uncharacterized ternary S4-synectin-RhoGDI1 protein complex and activation via PKCalpha. | Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway.
Elfenbein A, Rhodes JM, Meller J, Schwartz MA, Matsuda M, Simons M., Free PMC Article | 01/21/2010 |
| In DGKzeta-deficient fibroblasts PAK1 phosphorylation and Rac1-RhoGDI dissociation were attenuated, leading to reduced Rac1 activation after platelet-derived growth factor stimulation. | Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI.
Abramovici H, Mojtabaie P, Parks RJ, Zhong XP, Koretzky GA, Topham MK, Gee SH., Free PMC Article | 01/21/2010 |
| liposomes supplemented with (PtdIns(3,4,5)P(3)) in conjunction with Rac, Trio, or Tiam1 and a non-hydrolyzable GTP analogue, cause dissociation of Rac1(GDP).RhoGDI complexes, GDP to GTP exchange on Rac1, and binding of Rac1(GTP) to the liposomes | Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP.
Ugolev Y, Berdichevsky Y, Weinbaum C, Pick E., Free PMC Article | 01/21/2010 |
| Differential expression of RhoGDI-1, cofilin 1 and tropomyosin 2 in calpain-deficient fibroblasts compared with wild-type fibroblasts | Genetic disruption of calpain correlates with loss of membrane blebbing and differential expression of RhoGDI-1, cofilin and tropomyosin.
Larsen AK, Lametsch R, Elce J, Larsen JK, Thomsen B, Larsen MR, Lawson MA, Greer PA, Ertbjerg P. | 01/21/2010 |
| isoprenylcysteine carboxylmethyltransferase regulates Rac1 activity by controlling the interaction of Rac1 with RhoGDI through TNFA | Tumor necrosis factor alpha stimulation of Rac1 activity. Role of isoprenylcysteine carboxylmethyltransferase.
Papaharalambus C, Sajjad W, Syed A, Zhang C, Bergo MO, Alexander RW, Ahmad M. | 01/21/2010 |
| Rho GDIalpha and Rho GDIbeta play synergistic roles in lymphocyte migration and development by modulating activation cycle of the Rho proteins in a lymphoid organ-specific manner. | Defective chemokine-directed lymphocyte migration and development in the absence of Rho guanosine diphosphate-dissociation inhibitors alpha and beta.
Ishizaki H, Togawa A, Tanaka-Okamoto M, Hori K, Nishimura M, Hamaguchi A, Imai T, Takai Y, Miyoshi J. | 01/21/2010 |
| Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. | Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation.
Wei L, Imanaka-Yoshida K, Wang L, Zhan S, Schneider MD, DeMayo FJ, Schwartz RJ. | 01/21/2010 |
| RhoGDI-1 regulates lung microvessel endothelial barrier function by repressing RhoA activity. | RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs.
Gorovoy M, Neamu R, Niu J, Vogel S, Predescu D, Miyoshi J, Takai Y, Kini V, Mehta D, Malik AB, Voyno-Yasenetskaya T. | 01/21/2010 |
| Increased expression of bovine Rho GDIalpha led to electrophysiological alterations that resulted in atrial arrhythmias and AV conduction abnormalities in transgenic mice, whereas ventricular contractile function was largely preserved. | Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved.
Wei L, Taffet GE, Khoury DS, Bo J, Li Y, Yatani A, Delaughter MC, Klevitsky R, Hewett TE, Robbins J, Michael LH, Schneider MD, Entman ML, Schwartz RJ. | 01/21/2010 |
| analysis of inhibitory and shuttling functions of rhoGDI-3 and rhoGDI-1 | Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors.
Dransart E, Morin A, Cherfils J, Olofsson B. | 01/21/2010 |