| Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth. | Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth.
Nagai K, Muto Y, Miura S, Takahashi K, Naruse Y, Hiruta R, Hashimoto Y, Uzuki M, Haga Y, Fujii R, Ueda K, Kawaguchi Y, Fujii M, Kitazume S., Free PMC Article | 11/2/2023 |
| Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth. | Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth.
Kastana P, Ntenekou D, Mourkogianni E, Enake MK, Xanthopoulos A, Choleva E, Marazioti A, Nikou S, Akwii RG, Papadaki E, Gramage E, Herradón G, Stathopoulos GT, Mikelis CM, Papadimitriou E., Free PMC Article | 09/6/2023 |
| Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype. | Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype.
Takahashi K, Kanekiyo K, Sakuda K, Muto Y, Iguchi M, Matsuda N, Hashimoto Y, Kanai K, Ogawa H, Hirase H, Kakita A, Bizen N, Takebayashi H, Kawaguchi Y, Uzuki M, Kitazume S. | 07/31/2023 |
| IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice. | IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice.
González-Sánchez HM, Baek JH, Weinmann-Menke J, Ajay AK, Charles JF, Noda M, Franklin RA, Rodríguez-Morales P, Kelley VR. | 07/30/2022 |
| Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease. | Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease.
Nagai K, Fujii M, Kitazume S., Free PMC Article | 04/30/2022 |
| Protein tyrosine phosphatase receptor-zeta1 deletion triggers defective heart morphogenesis in mice and zebrafish. | Protein tyrosine phosphatase receptor-ζ1 deletion triggers defective heart morphogenesis in mice and zebrafish.
Katraki-Pavlou S, Kastana P, Bousis D, Ntenekou D, Varela A, Davos CH, Nikou S, Papadaki E, Tsigkas G, Athanasiadis E, Herradon G, Mikelis CM, Beis D, Papadimitriou E., Free PMC Article | 02/19/2022 |
| The protein tyrosine phosphatase RPTPzeta/phosphacan is critical for perineuronal net structure. | The protein tyrosine phosphatase RPTPζ/phosphacan is critical for perineuronal net structure.
Eill GJ, Sinha A, Morawski M, Viapiano MS, Matthews RT., Free PMC Article | 09/5/2020 |
| Ptprz knock-out mice exhibited an increased locomotor response to novelty, whereas their locomotor response to methamphetamine (METH) was reduced. Furthermore, Ptprz deficiency may reduce cell surface dopamine (DA) transporter proteins expression, thereby reducing METH-evoked DA release. | Mice deficient in protein tyrosine phosphatase receptor type Z (PTPRZ) show reduced responsivity to methamphetamine despite an enhanced response to novelty.
Fujikawa A, Noda Y, Yamamoto H, Tanga N, Sakaguchi G, Hattori S, Song WJ, Sora I, Nabeshima T, Katsuura G, Noda M., Free PMC Article | 04/4/2020 |
| results suggest that the extracellular region of PTPRZ, including the secretory isoform, is crucial for behavioral responses to novelty and the formation of aversive memories, whereas the PTPase activities of PTPRZ receptor isoforms are involved in regulating the dopaminergic system | Behavioral and neurological analyses of adult mice carrying null and distinct loss-of-receptor function mutations in protein tyrosine phosphatase receptor type Z (PTPRZ).
Tanga N, Kuboyama K, Kishimoto A, Kihara M, Kiyonari H, Watanabe T, Fujikawa A, Noda M., Free PMC Article | 02/15/2020 |
| High PTPRZ1 expression is associated with glioblastoma. | Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells.
Fujikawa A, Sugawara H, Tanaka T, Matsumoto M, Kuboyama K, Suzuki R, Tanga N, Ogata A, Masumura M, Noda M., Free PMC Article | 02/16/2019 |
| Molecular crosstalk between tumour-associated macrophages and glioma stem cells through PTN-PTPRZ1 paracrine signalling supports glioblastoma malignant growth. | Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth.
Shi Y, Ping YF, Zhou W, He ZC, Chen C, Bian BS, Zhang L, Chen L, Lan X, Zhang XC, Zhou K, Liu Q, Long H, Fu TW, Zhang XN, Cao MF, Huang Z, Fang X, Wang X, Feng H, Yao XH, Yu SC, Cui YH, Zhang X, Rich JN, Bao S, Bian XW., Free PMC Article | 11/10/2018 |
| These results suggest that sub-isoforms of PTPRZ have different functions because of variations in the wedge structure. | Identification of novel splicing variants of protein tyrosine phosphatase receptor type Z.
Fujikawa A, Chow JPH, Matsumoto M, Suzuki R, Kuboyama K, Yamamoto N, Noda M. | 11/25/2017 |
| these data indicate that PTN-PTPRZ-A signaling controls the timing of oligodendrocyte precursor cell differentiation in vivo, in which the CS moiety of PTPRZ receptors maintains them in a monomeric active state until its ligand binding. | Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.
Kuboyama K, Fujikawa A, Suzuki R, Tanga N, Noda M., Free PMC Article | 05/13/2017 |
| The Protein Tyrosine Phosphatase Rptpzeta Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice | The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice.
Baldauf C, Jeschke A, Kanbach V, Catala-Lehnen P, Baumhoer D, Gerull H, Buhs S, Amling M, Nollau P, Harroch S, Schinke T., Free PMC Article | 05/28/2016 |
| The Pleiotrophin-induced inactivation of PTPRZ was considered to be the adaptive mechanism underlying CNS remyelination in vivo. | Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells.
Kuboyama K, Fujikawa A, Suzuki R, Noda M., Free PMC Article | 11/28/2015 |
| Abnormal glycosylation of RPTP-zeta/phosphacan is neural cell-specific and may play a role in congenital muscular dystrophies. | Neurons and glia modify receptor protein-tyrosine phosphatase ζ (RPTPζ)/phosphacan with cell-specific O-mannosyl glycans in the developing brain.
Dwyer CA, Katoh T, Tiemeyer M, Matthews RT., Free PMC Article | 06/20/2015 |
| Ptprz plays a negative role in oligodendrocyte differentiation in early central nervous system (CNS) development and remyelination in demyelinating CNS diseases. | Protein tyrosine phosphatase receptor type z negatively regulates oligodendrocyte differentiation and myelination.
Kuboyama K, Fujikawa A, Masumura M, Suzuki R, Matsumoto M, Noda M., Free PMC Article | 05/25/2013 |
| RPTPbeta/zeta is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes. | Increased expression of receptor phosphotyrosine phosphatase-β/ζ is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes.
Takahashi N, Sakurai T, Bozdagi-Gunal O, Dorr NP, Moy J, Krug L, Gama-Sosa M, Elder GA, Koch RJ, Walker RH, Hof PR, Davis KL, Buxbaum JD., Free PMC Article | 04/6/2013 |
| Ptprz is necessary to maintain central nervous system axonal integrity in a demyelinating environment. | Accelerated axonal loss following acute CNS demyelination in mice lacking protein tyrosine phosphatase receptor type Z.
Huang JK, Ferrari CC, Monteiro de Castro G, Lafont D, Zhao C, Zaratin P, Pouly S, Greco B, Franklin RJ., Free PMC Article | 03/23/2013 |
| Loss of RPTPZ promotes prostate cancer metastasi. | Loss of receptor protein tyrosine phosphatase β/ζ (RPTPβ/ζ) promotes prostate cancer metastasis.
Diamantopoulou Z, Kitsou P, Menashi S, Courty J, Katsoris P., Free PMC Article | 03/2/2013 |
| spatial and temporal expression patterns of O-mannosylated forms of RPTPzeta/phosphacan and its hypoglycosylation are suggestive of a role in the neural phenotypes observed in Congenital muscular dystrophies | RPTPζ/phosphacan is abnormally glycosylated in a model of muscle-eye-brain disease lacking functional POMGnT1.
Dwyer CA, Baker E, Hu H, Matthews RT., Free PMC Article | 12/22/2012 |
| An understanding of the specific functional role for phosphacan in stem cell neurobiology will be important for the therapeutic facilitation of nervous tissue repair and regeneration. | Glypican-1, phosphacan/receptor protein-tyrosine phosphatase-ζ/β and its ligand, tenascin-C, are expressed by neural stem cells and neural cells derived from embryonic stem cells.
Abaskharoun M, Bellemare M, Lau E, Margolis RU., Free PMC Article | 12/10/2011 |
| findings assign novel functional role of RPTPz in motor coordination and nociception | A novel role for receptor like protein tyrosine phosphatase zeta in modulation of sensorimotor responses to noxious stimuli: evidences from knockout mice studies.
Lafont D, Adage T, Gréco B, Zaratin P. | 01/21/2010 |
| the cleavage sites in the extracellular juxtamembrane region of Ptprz by tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase 9. | Metalloproteinase- and gamma-secretase-mediated cleavage of protein-tyrosine phosphatase receptor type Z.
Chow JP, Fujikawa A, Shimizu H, Suzuki R, Noda M., Free PMC Article | 01/21/2010 |
| Protein tyrosine phosphatase receptor type Z is a physiological target for activity-dependent proteolytic processing by the tPA/plasmin system | Plasmin-mediated processing of protein tyrosine phosphatase receptor type Z in the mouse brain.
Chow JP, Fujikawa A, Shimizu H, Noda M. | 01/21/2010 |