| Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions. | Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions.
Weidner AE, Roy A, Vann K, Walczyk AC, Astapova O., Free PMC Article | 06/5/2024 |
| ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway. | ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.
Saikia BB, Bhowmick S, Malat A, Preetha Rani MR, Thaha A, Abdul-Muneer PM., Free PMC Article | 03/21/2024 |
| Paxillin knockout in mouse granulosa cells increases fecunditydagger. | Paxillin knockout in mouse granulosa cells increases fecundity†.
Vann K, Weidner AE, Walczyk AC, Astapova O., Free PMC Article | 02/16/2024 |
| Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation. | Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation.
Zhang Y, Li N, Kobayashi S., Free PMC Article | 02/12/2024 |
| A Critical Balance Between PAX8 and the Hippo Mediator TAZ Determines Sodium/Iodide Symporter Expression and Function. | A Critical Balance Between PAX8 and the Hippo Mediator TAZ Determines Sodium/Iodide Symporter Expression and Function.
Fernández-Méndez C, Santisteban P. | 05/14/2022 |
| Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity. | Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity.
Xu W, Alpha KM, Zehrbach NM, Turner CE., Free PMC Article | 04/2/2022 |
| Structural and functional analysis of LIM domain-dependent recruitment of paxillin to alphavbeta3 integrin-positive focal adhesions. | Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.
Ripamonti M, Liaudet N, Azizi L, Bouvard D, Hytönen VP, Wehrle-Haller B., Free PMC Article | 08/14/2021 |
| Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome. | Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome.
Wang W, Hu D, Feng Y, Wu C, Song Y, Liu W, Li A, Wang Y, Chen K, Tian M, Xiao F, Zhang Q, Chen W, Pan P, Wan P, Liu Y, Lan H, Wu K, Wu J., Free PMC Article | 07/3/2021 |
| Plk1 Mediates Paxillin Phosphorylation (Ser-272), Centrosome Maturation, and Airway Smooth Muscle Layer Thickening in Allergic Asthma. | Plk1 Mediates Paxillin Phosphorylation (Ser-272), Centrosome Maturation, and Airway Smooth Muscle Layer Thickening in Allergic Asthma.
Rezey AC, Gerlach BD, Wang R, Liao G, Tang DD., Free PMC Article | 10/24/2020 |
| Despite sharing the same binding mode with leupaxin, paxillin recruitment into podosomes is kindlin-3 independent. | A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability.
Klapproth S, Bromberger T, Türk C, Krüger M, Moser M., Free PMC Article | 05/16/2020 |
| the focal adhesion component paxillin is a cytoplasmic substrate of Ccnd1.Cdk4. | Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin.
Fusté NP, Fernández-Hernández R, Cemeli T, Mirantes C, Pedraza N, Rafel M, Torres-Rosell J, Colomina N, Ferrezuelo F, Dolcet X, Garí E., Free PMC Article | 09/8/2018 |
| Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin. | Kindlin supports platelet integrin αIIbβ3 activation by interacting with paxillin.
Gao J, Huang M, Lai J, Mao K, Sun P, Cao Z, Hu Y, Zhang Y, Schulte ML, Jin C, Wang J, White GC, Xu Z, Ma YQ., Free PMC Article | 06/16/2018 |
| Kindlin-2 is a key protein that couples cell adhesion by activating integrins and the induction of membrane protrusions by activating Rac1 and supplying Rac1 with the Arp2/3 complex. | Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.
Böttcher RT, Veelders M, Rombaut P, Faix J, Theodosiou M, Stradal TE, Rottner K, Zent R, Herzog F, Fässler R., Free PMC Article | 11/25/2017 |
| paxillin and FAK function cell-autonomously to control migrating neuron morphology and speed during cortical development. | Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation.
Rashid M, Belmont J, Carpenter D, Turner CE, Olson EC., Free PMC Article | 11/18/2017 |
| paxillin interacts with processed LC3 through a conserved LIR motif in the amino-terminal end of paxillin and that this interaction is regulated by oncogenic SRC activity. | Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3.
Sharifi MN, Mowers EE, Drake LE, Collier C, Chen H, Zamora M, Mui S, Macleod KF., Free PMC Article | 11/18/2017 |
| Data show that actomyosin cytoskeletal contractility is required for paxillin localization to developing somite boundaries. | Paxillin genes and actomyosin contractility regulate myotome morphogenesis in zebrafish.
Jacob AE, Amack JD, Turner CE., Free PMC Article | 09/16/2017 |
| paxillin and Hic-5 have both redundant and distinctive functions in invadosome formation. | Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes.
Petropoulos C, Oddou C, Emadali A, Hiriart-Bryant E, Boyault C, Faurobert E, Vande Pol S, Kim-Kaneyama JR, Kraut A, Coute Y, Block M, Albiges-Rizo C, Destaing O., Free PMC Article | 06/3/2017 |
| Fyn mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin phosphorylation | Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation In Vitro.
Lv Z, Hu M, Ren X, Fan M, Zhen J, Chen L, Lin J, Ding N, Wang Q, Wang R., Free PMC Article | 12/24/2016 |
| Lithium therapy abrogated GSK3beta overactivity, blunted paxillin hyperphosphorylation, and reinstated actin cytoskeleton integrity in glomeruli associated with an early attenuation of podocyte foot process effacement. | Glycogen synthase kinase 3β dictates podocyte motility and focal adhesion turnover by modulating paxillin activity: implications for the protective effect of low-dose lithium in podocytopathy.
Xu W, Ge Y, Liu Z, Gong R., Free PMC Article | 05/7/2016 |
| Suggest paxillin up-regulation and phosphorylation as an important mechanism of vascular remodelling underlying pulmonary hypertension. | Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment.
Veith C, Zakrzewicz D, Dahal BK, Bálint Z, Murmann K, Wygrecka M, Seeger W, Schermuly RT, Weissmann N, Kwapiszewska G. | 11/14/2015 |
| LPS-induced paxillin phosphorylation at Y31 and Y118 was mediated by c-Abl tyrosine kinase | c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury.
Fu P, Usatyuk PV, Lele A, Harijith A, Gregorio CC, Garcia JG, Salgia R, Natarajan V., Free PMC Article | 08/1/2015 |
| Study provides evidence that phosphorylation of PXN is required for cisplatin resistance in lung cancer cells. | Phosphorylation of paxillin confers cisplatin resistance in non-small cell lung cancer via activating ERK-mediated Bcl-2 expression.
Wu DW, Wu TC, Wu JY, Cheng YW, Chen YC, Lee MC, Chen CY, Lee H. | 04/18/2015 |
| MELK promotes cell migration and invasion via the FAK/Paxillin pathway, and plays an important role in the occurrence and development of gastric cancer. | Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway.
Du T, Qu Y, Li J, Li H, Su L, Zhou Q, Yan M, Li C, Zhu Z, Liu B., Free PMC Article | 01/17/2015 |
| FAK-paxillin interactions are indispensable for cell adhesion, migration and invasion processes. | Altering FAK-paxillin interactions reduces adhesion, migration and invasion processes.
Deramaudt TB, Dujardin D, Noulet F, Martin S, Vauchelles R, Takeda K, Rondé P., Free PMC Article | 12/20/2014 |
| paxillin and zyxin are LIM-domain adaptor proteins that are recruited to stress fiber strain sites | LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain.
Smith MA, Blankman E, Deakin NO, Hoffman LM, Jensen CC, Turner CE, Beckerle MC., Free PMC Article | 04/26/2014 |