| Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain. | Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain.
Singh V, Menard MA, Serrano GE, Beach TG, Zhao HT, Riley-DiPaolo A, Subrahmanian N, LaVoie MJ, Volpicelli-Daley LA., Free PMC Article | 01/3/2024 |
| Behavioral and Transcriptome Profiling of Heterozygous Rab10 Knock-Out Mice. | Behavioral and Transcriptome Profiling of Heterozygous Rab10 Knock-Out Mice.
Bunner W, Wang J, Cohen S, Bashtovyy D, Perry R, Shookster D, Landry T, Harris EM, Stackman R, Tran TD, Yasuda R, Szatmari EM., Free PMC Article | 05/25/2023 |
| Mice with the Rab10 T73V mutation exhibit anxiety-like behavior and alteration of neuronal functions in the striatum. | Mice with the Rab10 T73V mutation exhibit anxiety-like behavior and alteration of neuronal functions in the striatum.
Zhang J, Li J, You P, Jiang H, Liu Y, Han D, Liu M, Yu H, Su B. | 03/28/2023 |
| Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport. | Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport.
Lazo OM, Schiavo G., Free PMC Article | 03/20/2023 |
| Rab10 protects against DOX-induced cardiotoxicity by alleviating the oxidative stress and apoptosis of cardiomyocytes. | Rab10 protects against DOX-induced cardiotoxicity by alleviating the oxidative stress and apoptosis of cardiomyocytes.
Zhang C, Dan Q, Lai S, Zhang Y, Gao E, Luo H, Yang L, Gao X, Lu C. | 12/31/2022 |
| Defective insulin-stimulated GLUT4 translocation in brown adipocytes induces systemic glucose homeostasis dysregulation independent of thermogenesis in female mice. | Defective insulin-stimulated GLUT4 translocation in brown adipocytes induces systemic glucose homeostasis dysregulation independent of thermogenesis in female mice.
Picatoste B, Yammine L, Leahey RA, Soares D, Johnson EF, Cohen P, McGraw TE., Free PMC Article | 03/26/2022 |
| Rab10-Positive Tubular Structures Represent a Novel Endocytic Pathway That Diverges From Canonical Macropinocytosis in RAW264 Macrophages. | Rab10-Positive Tubular Structures Represent a Novel Endocytic Pathway That Diverges From Canonical Macropinocytosis in RAW264 Macrophages.
Kawai K, Nishigaki A, Moriya S, Egami Y, Araki N., Free PMC Article | 10/2/2021 |
| Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues. | Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues.
Iannotta L, Biosa A, Kluss JH, Tombesi G, Kaganovich A, Cogo S, Plotegher N, Civiero L, Lobbestael E, Baekelandt V, Cookson MR, Greggio E., Free PMC Article | 09/11/2021 |
| Insulin-promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10. | Insulin-promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10.
Brumfield A, Chaudhary N, Molle D, Wen J, Graumann J, McGraw TE., Free PMC Article | 08/14/2021 |
| LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes. | LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.
Liu Z, Xu E, Zhao HT, Cole T, West AB., Free PMC Article | 04/17/2021 |
| These results implicate the stress-responsive machinery composed of Rab7L1, LRRK2, phosphorylated Rab8/10, and their downstream effectors in the maintenance of lysosomal homeostasis. | LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
Eguchi T, Kuwahara T, Sakurai M, Komori T, Fujimoto T, Ito G, Yoshimura SI, Harada A, Fukuda M, Koike M, Iwatsubo T., Free PMC Article | 10/20/2018 |
| Rab10 plays a role in oligodendrocyte precursor cell maturation. | Rab10 Disruption Results in Delayed OPC Maturation.
Zhang ZH, Zhao WQ, Ma FF, Zhang H, Xu XH. | 07/14/2018 |
| SEC16A and RAB10 promote insulin-stimulated mobilization of GLUT4 from a perinuclear recycling endosome/trans Golgi network compartment. | SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes.
Bruno J, Brumfield A, Chaudhary N, Iaea D, McGraw TE., Free PMC Article | 06/3/2017 |
| Glut4 traffics predominantly through the specialized Rab10-dependent pathway both before and after insulin stimulation. | Glut4 Is Sorted from a Rab10 GTPase-independent Constitutive Recycling Pathway into a Highly Insulin-responsive Rab10 GTPase-dependent Sequestration Pathway after Adipocyte Differentiation.
Brewer PD, Habtemichael EN, Romenskaia I, Mastick CC, Coster AC., Free PMC Article | 05/21/2016 |
| role of Rab10 in mouse embryo | Targeted disruption of Rab10 causes early embryonic lethality.
Lv P, Sheng Y, Zhao Z, Zhao W, Gu L, Xu T, Song E., Free PMC Article | 02/20/2016 |
| These results suggest that the association of Rab10-GTP with Exoc6/6b is a molecular link between insulin signaling and the exocytic machinery in GLUT4 translocation. | A potential link between insulin signaling and GLUT4 translocation: Association of Rab10-GTP with the exocyst subunit Exoc6/6b.
Sano H, Peck GR, Blachon S, Lienhard GE., Free PMC Article | 11/28/2015 |
| RAB10 and its GTPase-activating protein AS160 comprise the principal signaling module downstream of insulin receptor activation that regulates the accumulation of GLUT4 transport vesicles at the plasma membrane. | Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs.
Sadacca LA, Bruno J, Wen J, Xiong W, McGraw TE., Free PMC Article | 04/5/2014 |
| Rab10 coordinates with myosin-Va to mediate the final steps of insulin-stimulated vesicle translocation to the plasma membrane. | Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes.
Chen Y, Wang Y, Zhang J, Deng Y, Jiang L, Song E, Wu XS, Hammer JA, Xu T, Lippincott-Schwartz J., Free PMC Article | 11/17/2012 |
| Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C | Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C.
Sano H, Peck GR, Kettenbach AN, Gerber SA, Lienhard GE., Free PMC Article | 07/16/2011 |
| show that continuous replenishment of TLR4 from Golgi to plasma membrane is regulated by the small GTPase Rab10, which is essential for optimal macrophage activation following ipopolysaccharide stimulation. | Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane.
Wang D, Lou J, Ouyang C, Chen W, Liu Y, Liu X, Cao X, Wang J, Lu L., Free PMC Article | 09/13/2010 |
| the subcellular distribution of Rab10, the fraction of Rab10 in the active GTP form in vivo; Rab10 participates in GLUT4 translocation in 3T3-L1 adipocytes | Rab10 in insulin-stimulated GLUT4 translocation.
Sano H, Roach WG, Peck GR, Fukuda M, Lienhard GE. | 01/21/2010 |
| Rab10 is a target of AS160 and a positive regulator of GLUT4 trafficking to the cell surface upon insulin stimulation. | Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane.
Sano H, Eguez L, Teruel MN, Fukuda M, Chuang TD, Chavez JA, Lienhard GE, McGraw TE. | 01/21/2010 |