| Rab18 maintains homeostasis of subcutaneous adipose tissue to prevent obesity-induced metabolic disorders. | Rab18 maintains homeostasis of subcutaneous adipose tissue to prevent obesity-induced metabolic disorders.
Liu J, Li L, Xu D, Li Y, Chen T, Liu Y, Bao Y, Wang Y, Yang L, Li P, Xu L. | 10/25/2024 |
| 2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity. | 2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity.
Deng Y, Hahn Q, Yu L, Zhu Z, Boyer JA, Wang J, Kong D, Carey LM, Hepperla AJ, Simon JM, Temple B, Zhang Z, Zhang Y, Santos C, Frank JE, Herring LE, Wang X, Dokholyan NV, Campbell SL, Baldwin AS, Damania B, Zhang Q, Liu P., Free PMC Article | 10/23/2024 |
| Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics. | Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics.
Deng Y, Zhou C, Mirza AH, Bamigbade AT, Zhang S, Xu S, Liu P. | 09/18/2021 |
| the functions of RAB18 and RAB7 in lysosomal and autophagic activities may constitute an overlapping mechanism underlying Warburg micro syndrome and Charcot-Marie-Tooth Neuropathy Type 2B pathogenesis in the nervous system. | Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B.
Nian FS, Li LL, Cheng CY, Wu PC, Lin YT, Tang CY, Ren BS, Tai CY, Fann MJ, Kao LS, Hong CJ, Tsai JW. | 01/11/2020 |
| data reveal that the Rab18-NRZ-SNARE complex is critical protein machinery for tethering endoplasmic reticulum-lipid droplet and establishing endoplasmic reticulum-lipid droplet contact to promote lipid droplet growth. | Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions.
Xu D, Li Y, Wu L, Li Y, Zhao D, Yu J, Huang T, Ferguson C, Parton RG, Yang H, Li P., Free PMC Article | 02/23/2019 |
| RAB18 regulates neuronal migration and morphogenesis during development. | RAB18, a protein associated with Warburg Micro syndrome, controls neuronal migration in the developing cerebral cortex.
Wu Q, Sun X, Yue W, Lu T, Ruan Y, Chen T, Zhang D., Free PMC Article | 10/22/2016 |
| Retinoid and cholesterol metabolism are linked in stellate cells by the LD-associated protein Rab18 and may have significant therapeutic benefit in liver fibrosis. | Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein.
O'Mahony F, Wroblewski K, O'Byrne SM, Jiang H, Clerkin K, Benhammou J, Blaner WS, Beaven SW., Free PMC Article | 10/17/2015 |
| The results of this study indicated that the sensory nervous system is more vulnerable to Rab18 deficiency and WARBM is not only a neurodevelopmental but also neurodegenerative disease. | ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18.
Cheng CY, Wu JC, Tsai JW, Nian FS, Wu PC, Kao LS, Fann MJ, Tsai SJ, Liou YJ, Tai CY, Hong CJ. | 07/25/2015 |
| apparent similarities between the WARBM phenotype and the phenotype that we describe here indicate that the Rab18-mutant mouse provides an important platform for investigation of the disease pathogenesis and therapeutic interventions | A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton.
Carpanini SM, McKie L, Thomson D, Wright AK, Gordon SL, Roche SL, Handley MT, Morrison H, Brownstein D, Wishart TM, Cousin MA, Gillingwater TH, Aligianis IA, Jackson IJ., Free PMC Article | 01/17/2015 |
| Data suggest that overexpression of Rab18 in its GDP-bound state favors peroxisome proliferation in hepatocytes; Rab18 (as well as Rab6, Rab10, and Rab14) localizes to the peroxisomal compartment. | Localization of Rab proteins to peroxisomes: a proteomics and immunofluorescence study.
Gronemeyer T, Wiese S, Grinhagens S, Schollenberger L, Satyagraha A, Huber LA, Meyer HE, Warscheid B, Just WW. | 04/6/2013 |
| in neuroendocrine cells, Rab18 acts as a negative regulator of secretory activity, likely by impairing secretory granule transport | Rab18 inhibits secretory activity in neuroendocrine cells by interacting with secretory granules.
Vazquez-Martinez R, Cruz-Garcia D, Duran-Prado M, Peinado JR, Castaño JP, Malagon MM. | 01/21/2010 |
| results show that a Rab protein localizes directly to the monolayer surface of lipid droplets | Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism.
Martin S, Driessen K, Nixon SJ, Zerial M, Parton RG. | 01/21/2010 |
| Rab18 regulates lipid droplet-associated membrane formation | Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane.
Ozeki S, Cheng J, Tauchi-Sato K, Hatano N, Taniguchi H, Fujimoto T. | 01/21/2010 |